Newest studies

Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells

41/100 ✓ Peer-reviewed Disease mechanisms Nature

Key finding: Recent evidence indicates that the Wnt cascade is the dominant force in controlling cell fate along the crypt-villus axis. +1 more finding

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Oxidative stress, mitochondrial dysfunction and cellular stress response in Friedreich's ataxia

36/100 ✓ Peer-reviewed Prevention and risk Journal of the neurological sciences

Key finding: There is significant evidence that the pathogenesis of several neurodegenerative diseases, including Parkinson's disease, Alzheimer's disease, Friedreich's ataxia (FRDA), multiple sclerosis and amyotrophic lateral sclerosis, may involve the generation of reactive oxygen species (ROS) and/or reactive nitrogen species (RNS) associated with mitochondrial dysfunction. +4 more findings

• Brain Biology
• Other Dementias

Full summary, score breakdown and related studies → Original source

Correlates of hippocampal neuron number in Alzheimer's disease and ischemic vascular dementia

40/100 ✓ Peer-reviewed Hippocampus size on brain scans Annals of neurology

Key finding: The objective of this article is to compare number and size of neurons in CA1 in AD versus ischemic vascular dementia. +2 more findings

• Brain Scans
• Brain Biology
• Other Dementias

Full summary, score breakdown and related studies → Original source

The last days of life of nursing home patients with and without dementia assessed with the palliative care outcome scale

36/100 ✓ Peer-reviewed End-of-life care Palliative medicine

Key finding: According to the NH staff, fairly good quality care was provided, but the psychosocial and spiritual aspects of care need to be addressed more in the last days of the dying NH patient's life. +1 more finding

• End-of-Life Care
• Care Services

Full summary, score breakdown and related studies → Original source

Influence of HAART on HIV-related CNS disease and neuroinflammation

44/100 ✓ Peer-reviewed Inflammation and the immune system Journal of neuropathology and experimental neurology

Key finding: In this autopsy study we examined post-HAART cases in Edinburgh for the presence of HIV-related pathology and in well-treated cases for evidence of neuroinflammation. +3 more findings

• Brain Biology

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Cloning and characterization of HIV-1-inducible astrocyte elevated gene-1, AEG-1

45/100 ✓ Peer-reviewed Inflammation and the immune system Gene

Key finding: Additionally, a novel method is outlined for producing tag-free recombinant protein in a baculovirus system and its use in producing AEG-1 protein. +3 more findings

• Brain Biology
• Genetics

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Dietary fatty acids and the risk of Parkinson disease: the Rotterdam study

62/100 ✓ Peer-reviewed Long-term cohort studies Neurology

Key finding: Unsaturated fatty acids are important constituents of neuronal cell membranes and have neuroprotective, antioxidant, and anti-inflammatory properties. +3 more findings

• Other Dementias
• Lifestyle

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Cerebral hypoperfusion and clinical onset of dementia: the Rotterdam Study

58/100 ✓ Peer-reviewed Long-term cohort studies Annals of neurology

Key finding: It is being debated whether this reflects diminished demand because of advanced neurodegeneration or that cerebral hypoperfusion contributes to dementia. +3 more findings

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Test-retest reliable coefficients and 5-year change scores for the MMSE and 3MS

40/100 ✓ Peer-reviewed Cognitive tests and assessment Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists

Key finding: (1975). "Mini-Mental State": A practical method for grading the cognitive state of patients for the clinician. +3 more findings

• Diagnosis

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Cognitive differences in dementia patients with autopsy-verified AD, Lewy body pathology, or both

55/100 ✓ Peer-reviewed Cognitive tests and assessment Neurology

Key finding: The authors reviewed 135 subjects from a community-based study of dementia for whom autopsy and brain tissue was available. +3 more findings

• Brain Biology
• Other Dementias

Full summary, score breakdown and related studies → Original source

Basal forebrain cholinergic dysfunction in Alzheimer's disease--interrelationship with beta-amyloid, inflammation and neurotrophin signaling

39/100 ✓ Peer-reviewed Risk genes beyond APOE Neurochemical research

Key finding: Deposition of extracellular neuritic, beta-amyloid peptide-containing plaques (senile plaques) in cerebral cortical regions of Alzheimer patients is accompanied by the presence of intracellular neurofibrillary tangles in cerebral pyramidal neurons. +3 more findings

• Brain Biology

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Precursor form of brain-derived neurotrophic factor and mature brain-derived neurotrophic factor are decreased in the pre-clinical stages of Alzheimer's disease

49/100 ✓ Peer-reviewed Mild cognitive impairment Journal of neurochemistry

Key finding: Previous studies have shown that BDNF mRNA and protein, including proBDNF, are dramatically decreased in end-stage AD brain. +2 more findings

• Early Stage

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The genetic epidemiology of neurodegenerative disease

52/100 ✓ Peer-reviewed Lewy body dementia The Journal of clinical investigation

Key finding: Gene defects play a major role in the pathogenesis of degenerative disorders of the nervous system. +2 more findings

• Other Dementias
• Genetics

Full summary, score breakdown and related studies → Original source

Effects of alpha-synuclein immunization in a mouse model of Parkinson's disease

49/100 ✓ Peer-reviewed Lewy body dementia Neuron

Key finding: Since previous studies suggest that immunization might be a potential therapy for Alzheimer's disease, we hypothesized that immunization with human (h)alpha-syn might have therapeutic effects in LBD. +3 more findings

• Other Dementias
• Brain Biology

Full summary, score breakdown and related studies → Original source

Down syndrome, Alzheimer's disease and seizures

40/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Brain & development

Key finding: Neuropathologically, Alzheimer-type abnormalities are demonstrated in patients with Down syndrome (DS), both demented and nondemented and more than a half of patients with DS above 50 years develop Alzheimer's disease (AD). +4 more findings

• Down Syndrome
• Genetics

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Relation of C-reactive protein to stroke, cognitive disorders, and depression in the general population: systematic review and meta-analysis

66/100 ✓ Peer-reviewed Risk factors The Lancet. Neurology

Key finding: Evidence suggests that a high concentration of C-reactive protein (CRP) is a cardiovascular risk factor and an important correlate of cognitive disorders and depression. +3 more findings

• Risk Factors

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Work stress and physical assault of nursing aides in rural nursing homes with and without dementia special care units

36/100 ✓ Peer-reviewed Disparities Journal of psychiatric and mental health nursing

Key finding: There was a trend toward increased risk of being assaulted in the last year associated with being in a non-SCU facility. +2 more findings

• Health Equity
• Care Services

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Family caregivers' subjective experiences of satisfaction in dementia care: aspects of burden, subjective health and sense of coherence

43/100 ✓ Peer-reviewed Caregiving Scandinavian journal of caring sciences

Key finding: The general aim of this study was to explore a previously developed instrument to study rewards gained by caregivers and to determine the factors associated with satisfaction in family members caring for patients with dementia living at home.

• Caregiving

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A cross-sectional study of neuropsychiatric symptoms in 435 patients with Alzheimer's disease

40/100 ✓ Peer-reviewed Caregiving The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

Key finding: Potentially treatable neuropsychiatric symptoms are common in AD and represent a major source of distress among caregivers. +3 more findings

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Reduced hippocampal metabolism in MCI and AD: automated FDG-PET image analysis

55/100 ✓ Peer-reviewed Brain scans and imaging Neurology

Key finding: The new HipMask technique provides accurate and rapid assessment of the hippocampus on PET without the use of regions of interest. +2 more findings

• Brain Scans
• Early Stage

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A randomized, double-blind, study of rofecoxib in patients with mild cognitive impairment

72/100 ✓ Peer-reviewed Getting a diagnosis Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

Key finding: Previous studies with the selective COX-2 inhibitors, rofecoxib and celecoxib, have shown that they do not alter the progression of AD. +2 more findings

• Clinical Trials
• Early Stage

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Sex differences in the clinical manifestations of Alzheimer disease pathology

62/100 ✓ Peer-reviewed Getting a diagnosis Archives of general psychiatry

Key finding: These data suggest that AD pathology is more likely to be clinically expressed as dementia in women than in men. +4 more findings

• Brain Biology

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Treatments for Alzheimer disease

48/100 ✓ Peer-reviewed Treatments Southern medical journal

Key finding: There is insufficient evidence to recommend ginkgo biloba, estrogen, statins, or nonsteroidal anti-inflammatory drugs for the prevention or treatment of AD. +4 more findings

• Treatments
• Clinical Trials

Full summary, score breakdown and related studies → Original source

Predictive utility of apolipoprotein E genotype for Alzheimer disease in outpatients with mild cognitive impairment

57/100 ✓ Peer-reviewed Genetics Archives of neurology

Key finding: APOE epsilon4 carrier status was associated with conversion to AD in older outpatients after controlling for known demographic and clinical risk factors, and APOE epsilon4 homozygosity was associated with increased risk of conversion to AD. +2 more findings

• Genetics
• Early Stage

Full summary, score breakdown and related studies → Original source

Genome-wide prediction of imprinted murine genes

44/100 ✓ Peer-reviewed Genetics Genome research

Key finding: They are involved in embryonic development, and imprinting dysregulation is linked to cancer, obesity, diabetes, and behavioral disorders such as autism and bipolar disease. +4 more findings

• Genetics

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