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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 24,001–24,025 of 27,380 studies, newest first · page 961 of 1096.

August 2004 24

  1. 2004-08 month only

    Apolipoprotein E and familial dysbetalipoproteinemia: clinical, biochemical, and genetic aspects

    ✓ Peer-reviewed Genetics Seminars in vascular medicine

    Key finding: This genetic variation is associated with different plasma lipoprotein levels, different response to diet and lipid-lowering therapy, and a variable risk for cardiovascular disease and Alzheimer's disease. +2 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2004-08-01

    The novel neuromodulator hydrogen sulfide: an endogenous peroxynitrite 'scavenger'?

    ✓ Peer-reviewed Disease mechanisms Journal of neurochemistry

    Key finding: H2S significantly inhibited peroxynitrite-mediated tyrosine nitration and inactivation of alpha1-antiproteinase to a similar extent to reduced glutathione at each concentration tested (30-250 microm). +1 more finding

    Full summary, score breakdown and related studies → Original source

  3. 2004-08-01

    LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms

    ✓ Peer-reviewed Vascular contributions Neuron

    Key finding: Here, we report amyloid beta-peptide Abeta40 binds to immobilized LRP clusters II and IV with high affinity (Kd = 0.6-1.2 nM) compared to Abeta42 and mutant Abeta, and LRP-mediated Abeta brain capillary binding, endocytosis, and transcytosis across the mouse blood-brain barrier are substantially reduced by the high beta sheet content in Abeta and deletion of the receptor-associated protein gene.

    Full summary, score breakdown and related studies → Original source

  4. 2004-08-01

    A new Alzheimer's disease interventive strategy: GLP-1

    ✓ Peer-reviewed Drug development Current drug targets

    Key finding: However emerging evidence suggests that stimulation of neuronal GLP-1 receptors plays an important role in regulating neuronal plasticity and cell survival. +1 more finding

    Full summary, score breakdown and related studies → Original source

  5. 2004-08-01

    Antisense directed at the Abeta region of APP decreases brain oxidative markers in aged senescence accelerated mice

    ✓ Peer-reviewed Drug development Brain research

    Key finding: Previous research has shown that a phosphorothiolated antisense oligonucleotide directed against the Abeta region of APP decreases the expression of APP and reverses deficits in learning and memory in aged SAMP8 mice. +4 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2004-08-01

    Enlarged amygdala volume and reduced hippocampal volume in young women with major depression

    ✓ Peer-reviewed Hippocampus size on brain scans Psychological medicine

    Key finding: Our results are consistent with previous findings of structural abnormalities of amygdala and hippocampus in subjects with recent-onset major depression. +4 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2004-08-01

    Using rapid-cycle quality improvement methodology to reduce feeding tubes in patients with advanced dementia: before and after study

    ✓ Peer-reviewed End-of-life care BMJ (Clinical research ed.)

    Key finding: Studies have found no evidence that feeding tubes in this population prevent aspiration, prolong life, improve overall function, or reduce pressure sores.

    Full summary, score breakdown and related studies → Original source

  8. 2004-08-01

    Government expenditures at the end of life for short- and long-stay nursing home residents: differences by hospice enrollment status

    ✓ Peer-reviewed End-of-life care Journal of the American Geriatrics Society

    Key finding: Overall, hospice care in NHs does not appear to increase government expenditures. +3 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2004-08-01

    Pathogenesis of and management strategies for postoperative delirium after hip fracture: a review

    ✓ Peer-reviewed Clinical safety Acta orthopaedica Scandinavica

    Key finding: Postoperative delirium is a serious complication. +3 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2004-08-01

    Posttranslational modifications of tau--role in human tauopathies and modeling in transgenic animals

    ✓ Peer-reviewed Disease mechanisms Current drug targets

    Key finding: In addition, tau is subject to ubiquitination, nitration, truncation, prolyl isomerization, association with heparan sulfate proteoglycan, glycosylation, glycation and modification by advanced glycation end-products (AGEs). +4 more findings

    Full summary, score breakdown and related studies → Original source

  11. 2004-08-01

    Neuronal expression of myeloperoxidase is increased in Alzheimer's disease

    ✓ Peer-reviewed Inflammation and the immune system Journal of neurochemistry

    Key finding: We now report that enzymatically active myeloperoxidase and its characteristic amino acid oxidation products are present in human brain. +3 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2004-08-01

    Inhibition of neurofibrillary degeneration: a promising approach to Alzheimer's disease and other tauopathies

    ✓ Peer-reviewed Tau biomarkers Current drug targets

    Key finding: To date in all known tauopathics including AD, the neurofibrillary changes, whether of paired helical filaments (PHF), twisted ribbons or straight filaments (SF) are made up of abnormally hyperphosphorylated tau, and the number of these lesions directly correlates to the degree of dementia in the affected individuals. +3 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2004-08-01

    Association of elevated phospho-tau levels with Alzheimer-typical 18F-fluoro-2-deoxy-D-glucose positron emission tomography findings in patients with mild cognitive impairment

    ✓ Peer-reviewed Tau biomarkers Biological psychiatry

    Key finding: Mild cognitive impairment is considered to be a transitional stage between normal aging and dementia. +3 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2004-08-01

    Presenilin mutations in familial Alzheimer disease and transgenic mouse models accelerate neuronal lysosomal pathology

    ✓ Peer-reviewed Risk genes beyond APOE Journal of neuropathology and experimental neurology

    Key finding: Here, we show that mutations of presenilin (PS) 1 and 2, which cause familial early-onset AD (FAD), induce more severe lysosomal system neuropathology in humans than does sporadic AD (SAD). +3 more findings

    Full summary, score breakdown and related studies → Original source

  15. 2004-08-01

    Diabetes, impaired fasting glucose, and development of cognitive impairment in older women

    ✓ Peer-reviewed Risk factors Neurology

    Key finding: A total of 267 (3.8%) women had diabetes and 297 (4.2%) had IFG. +2 more findings

    Full summary, score breakdown and related studies → Original source

  16. 2004-08-01

    Depression in patients with mild cognitive impairment increases the risk of developing dementia of Alzheimer type: a prospective cohort study

    ✓ Peer-reviewed How common it is Archives of neurology

    Key finding: We conclude that patients with mild cognitive impairment and depression are at more than twice the risk of developing dementia of Alzheimer type as those without depression. +3 more findings

    Full summary, score breakdown and related studies → Original source

  17. 2004-08-01

    Thematic review series: brain Lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal

    ✓ Peer-reviewed How common it is Journal of lipid research

    Key finding: In all animals, most growth and differentiation of the CNS occurs in the first few weeks or years after birth, and the cholesterol required for this growth apparently comes exclusively from de novo synthesis. +4 more findings

    Full summary, score breakdown and related studies → Original source

  18. 2004-08-01

    Black/White differences in pressure ulcer incidence in nursing home residents

    ✓ Peer-reviewed Disparities Journal of the American Geriatrics Society

    Key finding: The incidence of PUs was 0.38 per person-year in the NH. +2 more findings

    Full summary, score breakdown and related studies → Original source

  19. 2004-08-01

    Ethnic differences in the prevalence and pattern of dementia-related behaviors

    ✓ Peer-reviewed Disparities Journal of the American Geriatrics Society

    Key finding: Overall, 92% of patients had one or more dementia-related behaviors. +2 more findings

    Full summary, score breakdown and related studies → Original source

  20. 2004-08-01

    Long-term care placement of dementia patients and caregiver health and well-being

    ✓ Peer-reviewed Caregiving JAMA

    Key finding: Caregivers who institutionalized their relative reported depressive symptoms and anxiety to be as high as they were while in-home caregivers. +3 more findings

    Full summary, score breakdown and related studies → Original source

  21. 2004-08-01

    Mapping hippocampal and ventricular change in Alzheimer disease

    ✓ Peer-reviewed Brain scans and imaging NeuroImage

    Key finding: Hippocampal atrophic rates and ventricular expansion were assessed statistically using surface-based permutation testing and were faster in AD than in controls. +4 more findings

    Full summary, score breakdown and related studies → Original source

  22. 2004-08-01

    Dietary niacin and the risk of incident Alzheimer's disease and of cognitive decline

    ✓ Peer-reviewed Prevention and risk Journal of neurology, neurosurgery, and psychiatry

    Key finding: Energy adjusted niacin intake had a protective effect on development of AD and cognitive decline. +3 more findings

    Full summary, score breakdown and related studies → Original source

  23. 2004-08-01

    Economic evaluation of donepezil in moderate to severe Alzheimer disease

    ✓ Peer-reviewed Treatments Neurology

    Key finding: This cost-consequence analysis reveals economic benefits of treatment of moderate to severe AD with donepezil.

    Full summary, score breakdown and related studies → Original source

  24. 2004-08-01

    Efficacy of donepezil in mild cognitive impairment: a randomized placebo-controlled trial

    ✓ Peer-reviewed Treatments Neurology

    Key finding: Although significant treatment effects were not seen in the primary efficacy measures, outcomes on secondary measures suggest promising directions for further evaluation of donepezil treatment in patients with MCI. +1 more finding

    Full summary, score breakdown and related studies → Original source

July 2004 1

  1. 2004-07-30

    Microglia and neuroinflammation: a pathological perspective

    ✓ Peer-reviewed Inflammation and the immune system Journal of neuroinflammation

    Key finding: Microglia make up the innate immune system of the central nervous system and are key cellular mediators of neuroinflammatory processes. +2 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →