Newest studies

Knowledge of dementia among South Asian (Indian) older people in Manchester, UK

38/100 ✓ Peer-reviewed Digital health tools International journal of geriatric psychiatry

Key finding: One hundred and ninety-one DKQs from Indian and 55 DKQs from Caucasian (white UK/Irish/European) older people were included in the analyses. +1 more finding

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Hippocampal shape analysis of Alzheimer disease based on machine learning methods

46/100 ✓ Peer-reviewed Digital health tools AJNR. American journal of neuroradiology

Key finding: Subtle and spatially complex deformation patterns of hippocampus between patients with AD and healthy control subjects can be detected by machine learning methods. +1 more finding

• Digital Tools

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Brain reserve hypothesis in dementia

62/100 ✓ Peer-reviewed How common it is Journal of Alzheimer's disease : JAD

Key finding: Epidemiological studies have also related these factors to the development of dementia, suggesting that intellectual challenges experienced across the whole life span may increase the brain reserve and be crucial for the occurrence of dementia symptoms in late life.

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Improving the quality of care for mild to moderate dementia: an evaluation of the Croydon Memory Service Model

44/100 ✓ Peer-reviewed Disparities International journal of geriatric psychiatry

Key finding: Six predefined service goals were set: high acceptability; high appropriate referral rate; successful engagement with people from minority ethnic groups; successful engagement with people with young onset dementia; focus on engagement with mild cases to enable early intervention; and an increase in the overall number of new cases of dementia seen. +2 more findings

• Health Equity

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Gray matter atrophy in Parkinson disease with dementia and dementia with Lewy bodies

49/100 ✓ Peer-reviewed Brain scans and imaging Neurology

Key finding: We found that despite a similar severity of dementia, patients with dementia with Lewy bodies (DLB) had more cortical atrophy than patients with Parkinson disease with dementia (PDD), indicating different brain substrates underlying dementia in the two syndromes. +4 more findings

• Other Dementias

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Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS-ADRDA criteria

63/100 ✓ Peer-reviewed Getting a diagnosis The Lancet. Neurology

Key finding: These new criteria are centred on a clinical core of early and significant episodic memory impairment.

• Diagnosis
• Brain Scans

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The neuroprotective effects of caffeine: a prospective population study (the Three City Study)

56/100 ✓ Peer-reviewed Prevention and risk Neurology

Key finding: The psychostimulant properties of caffeine appear to reduce cognitive decline in women without dementia, especially at higher ages. +1 more finding

• Risk Factors

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Essential hypertension

55/100 ✓ Peer-reviewed Prevention and risk Lancet (London, England)

Key finding: Subtle target-organ damage such as left-ventricular hypertrophy, microalbuminuria, and cognitive dysfunction takes place early in the course of hypertensive cardiovascular disease, although catastrophic events such as stroke, heart attack, renal failure, and dementia usually happen after long periods of uncontrolled hypertension only. +4 more findings

• Risk Factors
• Prevention

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C-terminal truncations in human 3'-5' DNA exonuclease TREX1 cause autosomal dominant retinal vasculopathy with cerebral leukodystrophy

40/100 ✓ Peer-reviewed Brain scans and imaging Nature genetics

Key finding: Autosomal dominant retinal vasculopathy with cerebral leukodystrophy is a microvascular endotheliopathy with middle-age onset. +3 more findings

• Genetics

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Systematic review of information and support interventions for caregivers of people with dementia

67/100 ✓ Peer-reviewed Caregiving BMC geriatrics

Key finding: There is little evidence that interventions aimed at supporting and/or providing information to carers of people with dementia are uniformly effective. +1 more finding

• Caregiving

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Epidemiologic studies of environmental exposures in Parkinson's disease

36/100 ✓ Peer-reviewed Risk factors Journal of the neurological sciences

Key finding: Increasing age and male sex appear to be associated with an increased risk of PD. +1 more finding

• Risk Factors
• Other Dementias

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Blood-based neurochemical diagnosis of vascular dementia: a pilot study

43/100 ✓ Peer-reviewed Biomarkers Journal of neurochemistry

Key finding: Blood-based tests for the differential diagnosis of Alzheimer's disease (AD) are under intensive investigation and have shown promising results with regard to Abeta40 and Abeta42 peptide species in incipient AD. +1 more finding

• Biomarkers
• Diagnosis
• Other Dementias

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Co-morbidity of TDP-43 proteinopathy in Lewy body related diseases

59/100 ✓ Peer-reviewed How common it is Acta neuropathologica

Key finding: Immunohistochemical analyses of TDP-43 in clinically well characterized and pathologically confirmed cases of DLB + AD, PD and PDD demonstrated TDP-43 pathology in the following percentage of cases: DLB + AD = 25/80 (31.3%); PD = 5/69 (7.2%); PDD = 4/21 (19%), while DLB and normal controls exhibited no (0/10, 0%) and one cases (1/33, 3%) presenting TDP-43 pathology, respectively. +2 more findings

• Other Dementias
• Brain Biology

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In dementia with Lewy bodies, Braak stage determines phenotype, not Lewy body distribution

48/100 ✓ Peer-reviewed Brain tissue and pathology Neurology

Key finding: We assigned cases according to the DLB consensus' categories and found a significant association with the premortem clinical diagnosis of DLB.

• Other Dementias

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Statins reduce amyloid-beta production through inhibition of protein isoprenylation

47/100 ✓ Peer-reviewed Risk genes beyond APOE The Journal of biological chemistry

Key finding: However, statin-mediated AD protection cannot be fully explained by reduction of cholesterol levels. +3 more findings

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Amygdala and hippocampal volumes in familial early onset major depressive disorder

36/100 ✓ Peer-reviewed Hippocampus size on brain scans Biological psychiatry

Key finding: Reduced hippocampal volume may be suggestive of a risk factor for developing MDD.

• Brain Scans
• Genetics

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The protocols for the 10/66 dementia research group population-based research programme

69/100 ✓ Peer-reviewed Caregiving BMC public health

Key finding: The 10/66 DRG baseline population-based studies are nearly complete. +4 more findings

• Clinical Trials
• Caregiving
• Risk Factors

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A fast diffeomorphic image registration algorithm

52/100 ✓ Peer-reviewed Brain scans and imaging NeuroImage

Key finding: This paper describes DARTEL, which is an algorithm for diffeomorphic image registration. +3 more findings

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Simvastatin is associated with a reduced incidence of dementia and Parkinson's disease

57/100 ✓ Peer-reviewed Risk factors BMC medicine

Key finding: We observed that simvastatin is associated with a significant reduction in the incidence of dementia in subjects > or =65 years, using any of three models. +4 more findings

• Risk Factors
• Other Dementias

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Metabolic syndrome and dementia risk in a multiethnic elderly cohort

57/100 ✓ Peer-reviewed Risk factors Dementia and geriatric cognitive disorders

Key finding: No association was found between MeSy and prevalent dementia. +4 more findings

• Risk Factors

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ACNP White Paper: update on use of antipsychotic drugs in elderly persons with dementia

65/100 ✓ Peer-reviewed Caregiving Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

Key finding: The largest number of antipsychotic prescriptions in older adults is for behavioral disturbances associated with dementia. +2 more findings

• Treatments
• Clinical Trials
• Side Effects

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Genome-wide expression analysis of cultured trophoblast with trisomy 21 karyotype

37/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Human reproduction (Oxford, England)

Key finding: Our results demonstrate that gene expression in trisomy 21 affected placentas significantly differs from that of chromosomally normal placentas, and this difference is only partially explained by over-expression of genes from chromosome 21. +4 more findings

• Down Syndrome
• Genetics

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Modulation of human neural stem cell differentiation in Alzheimer (APP23) transgenic mice by phenserine

43/100 ✓ Peer-reviewed Biomarkers Proceedings of the National Academy of Sciences of the United States of America

Key finding: In a previous study, we found that human neural stem cells (HNSCs) exposed to high concentrations of secreted amyloid-precursor protein (sAPP) in vitro differentiated into mainly astrocytes, suggesting that pathological alterations in APP processing during neurodegenerative conditions such as Alzheimer's disease (AD) may prevent neuronal differentiation of HNSCs. +4 more findings

• Brain Biology
• Treatments

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Capitalizing on cortical plasticity: influence of physical activity on cognition and brain function

43/100 ✓ Peer-reviewed Prevention trials Trends in cognitive sciences

Key finding: We suggest that this literature supports the claim that physical activity enhances cognitive and brain function, and protects against the development of neurodegenerative diseases. +1 more finding

• Lifestyle

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Main morbidities recorded in the women's international study of long duration oestrogen after menopause (WISDOM): a randomised controlled trial of hormone replacement therapy in postmenopausal women

70/100 ✓ Peer-reviewed Prevention and risk BMJ (Clinical research ed.)

Key finding: Hormone replacement therapy increases cardiovascular and thromboembolic risk when started many years after the menopause. +4 more findings

• Clinical Trials
• Treatments

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