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DWI predicts future progression to Alzheimer disease in amnestic mild cognitive impairment
Kantarci K, Petersen RC, Boeve BF, Knopman DS, Weigand SD, O'Brien PC, Shiung MM, Smith GE et al.. Neurology, 2005-03-01
Topic: Amyloid, tau and blood-test diagnosis
The authors assessed whether measures of hippocampal water diffusivity at baseline can predict future progression to Alzheimer disease (AD) in amnestic mild cognitive impairment (aMCI). Higher baseline hippocampal diffusivity was associated with a greater risk of progression to AD in aMCI (p = 0.002). Magnetic resonance diffusion-weighted imaging may help identify patients with aMCI who will progress to AD as well as or better than structural MRI measures of hippocampal atrophy.
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APA 7th
Kantarci, K., Petersen, R. C., Boeve, B. F., Knopman, D. S., Weigand, S. D., O'Brien, P. C., et al. (2005). DWI predicts future progression to Alzheimer disease in amnestic mild cognitive impairment. Neurology. https://doi.org/10.1212/01.wnl.0000153076.46126.e9
Vancouver
Kantarci K, Petersen RC, Boeve BF, Knopman DS, Weigand SD, O'Brien PC, et al. DWI predicts future progression to Alzheimer disease in amnestic mild cognitive impairment. Neurology. 2005. doi:10.1212/01.wnl.0000153076.46126.e9. PMID: 15753434.
BibTeX
@article{kantarci2005-15753434,
author = {Kantarci, K. and Petersen, R. C. and Boeve, B. F. and Knopman, D. S. and Weigand, S. D. and O'Brien, P. C. and Shiung, M. M. and Smith, G. E. and others},
title = {{DWI predicts future progression to Alzheimer disease in amnestic mild cognitive impairment}},
journal = {Neurology},
year = {2005},
doi = {10.1212/01.wnl.0000153076.46126.e9},
pmid = {15753434},
url = {https://doi.org/10.1212/01.wnl.0000153076.46126.e9}
}
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Key findings
- Higher baseline hippocampal diffusivity was associated with a greater risk of progression to AD in aMCI (p = 0.002).
Why it matters
In amnestic mild cognitive impairment, higher baseline hippocampal water diffusivity was associated with greater risk of progressing to Alzheimer disease. This suggests a possible way to identify who will progress, but it offers no treatment or cure.
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Study details
- Evidence strengthLow
How this study scored 50/100
Published in a leading specialty journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Neurology) |
| Journal's citation record | 4 / 4 | Neurology: journal h-index 525 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2005 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 252 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 11.0 citations a year over 23 year(s) since 2005 |
| Impact for its field and year | 4 / 6 | Cited 9.6× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 3 / 6 | Cited by 13 other studies in this library |
| Still being cited | 2 / 4 | Cited 26 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Clifford R. Jack: h-index 203 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | Mayo Clinic: institution h-index 1,606 (OpenAlex) |
| Multicenter collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 15753434) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 50 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1212/01.wnl.0000153076.46126.e9
- PubMed: 15753434
- Original source →
- Free full text: PubMed Central →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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