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Alzheimer disease and Down syndrome: factors in pathogenesis
Lott IT, Head E.. Neurobiology of aging, 2005-03-01
Topic: Amyloid, tau and blood-test diagnosis
There is evidence to suggest that certain shared features exist in the pathogenesis of vascular disease and Alzheimer disease (AD) in the general population. In Down syndrome (DS) all adults over the age of 40 years develop sufficient neuropathology for a diagnosis of AD. However, vascular disease is not as common in DS as it is in the general population, particularly with respect to the development of atheromas. We discuss biological mechanisms and risk factors that may be common to both diseases including cholesterol metabolism, inflammation, plasminogen activator inhibitor and apolipoprotein E (Apo E). The study of individuals with DS may help to identify common pathogenic links as well as a disassociation between vascular disease and AD.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Lott, I. T., & Head, E. (2005). Alzheimer disease and Down syndrome: factors in pathogenesis. Neurobiology of aging. https://doi.org/10.1016/j.neurobiolaging.2004.08.005
Vancouver
Lott IT, Head E. Alzheimer disease and Down syndrome: factors in pathogenesis. Neurobiology of aging. 2005. doi:10.1016/j.neurobiolaging.2004.08.005. PMID: 15639317.
BibTeX
@article{lott2005-15639317,
author = {Lott, I. T. and Head, E.},
title = {{Alzheimer disease and Down syndrome: factors in pathogenesis}},
journal = {Neurobiology of aging},
year = {2005},
doi = {10.1016/j.neurobiolaging.2004.08.005},
pmid = {15639317},
url = {https://doi.org/10.1016/j.neurobiolaging.2004.08.005}
}
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Key findings
- There is evidence to suggest that certain shared features exist in the pathogenesis of vascular disease and Alzheimer disease (AD) in the general population.
Why it matters
This review discusses shared features of vascular disease and Alzheimer disease, noting that although nearly all adults with Down syndrome over 40 develop Alzheimer neuropathology, vascular disease such as atheromas is less common in them. It proposes that studying Down syndrome may help identify common pathogenic links but reports no treatment or cure.
Study details
- Evidence strengthLow
How this study scored 43/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Neurobiology of aging) |
| Journal's citation record | 3 / 4 | Neurobiology of Aging: journal h-index 263 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2005 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 212 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 9.2 citations a year over 23 year(s) since 2005 |
| Impact for its field and year | 3 / 6 | Cited 4.6× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 3 / 6 | Cited by 12 other studies in this library |
| Still being cited | 1 / 4 | Cited 10 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Elizabeth Head: h-index 98 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | University of California, Irvine: institution h-index 1,195 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 15639317) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 43 / 100 | — |
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