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Mechanisms, pathophysiology, and therapy of arterial stiffness
Zieman SJ, Melenovsky V, Kass DA.. Arteriosclerosis, thrombosis, and vascular biology, 2005-02-24
Topic: Brain proteins, microglia and lab models
Arterial stiffness is a growing epidemic associated with increased risk of cardiovascular events, dementia, and death. Decreased compliance of the central vasculature alters arterial pressure and flow dynamics and impacts cardiac performance and coronary perfusion. This article reviews the structural, cellular, and genetic contributors to arterial stiffness, including the roles of the scaffolding proteins, extracellular matrix, inflammatory molecules, endothelial cell function, and reactive oxidant species. Additional influences of atherosclerosis, glucose regulation, chronic renal disease, salt, and changes in neurohormonal regulation are discussed. A review of the hemodynamic impact of arterial stiffness follows. A number of lifestyle changes and therapies that reduce arterial stiffness are presented, including weight loss, exercise, salt reduction, alcohol consumption, and neuroendocrine-directed therapies, such as those targeting the renin-angiotensin aldosterone system, natriuretic peptides, insulin modulators, as well as novel therapies that target advanced glycation end products.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Zieman, S. J., Melenovsky, V., & Kass, D. A. (2005). Mechanisms, pathophysiology, and therapy of arterial stiffness. Arteriosclerosis, thrombosis, and vascular biology. https://doi.org/10.1161/01.atv.0000160548.78317.29
Vancouver
Zieman SJ, Melenovsky V, Kass DA. Mechanisms, pathophysiology, and therapy of arterial stiffness. Arteriosclerosis, thrombosis, and vascular biology. 2005. doi:10.1161/01.atv.0000160548.78317.29. PMID: 15731494.
BibTeX
@article{zieman2005-15731494,
author = {Zieman, S. J. and Melenovsky, V. and Kass, D. A.},
title = {{Mechanisms, pathophysiology, and therapy of arterial stiffness}},
journal = {Arteriosclerosis, thrombosis, and vascular biology},
year = {2005},
doi = {10.1161/01.atv.0000160548.78317.29},
pmid = {15731494},
url = {https://doi.org/10.1161/01.atv.0000160548.78317.29}
}
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Key findings
- Arterial stiffness is a growing epidemic associated with increased risk of cardiovascular events, dementia, and death.
Why it matters
Arterial stiffness is described as a growing condition linked to increased risk of cardiovascular events, dementia, and death. The review discusses lifestyle changes and therapies that reduce arterial stiffness, which might help lower these risks.
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Study details
- Evidence strengthLow
How this study scored 54/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Arteriosclerosis, thrombosis, and vascular biology) |
| Journal's citation record | 3 / 4 | Arteriosclerosis Thrombosis and Vascular Biology: journal h-index 340 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2005 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 7 / 7 | Cited 1,851 times (OpenAlex, 2026-10-10) |
| Citations per year | 5 / 5 | 80.5 citations a year over 23 year(s) since 2005 |
| Impact for its field and year | 5 / 6 | Cited 31.1× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 5 other studies in this library |
| Still being cited | 4 / 4 | Cited 263 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author David A. Kass: h-index 139 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | Johns Hopkins University: institution h-index 2,306 (OpenAlex) |
| Multicenter collaboration | 1 / 3 | OpenAlex lists 3 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 15731494) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 54 / 100 | — |
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