Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 25,001–25,025 of 27,380 studies, newest first · page 1001 of 1096.
December 2001 18
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2001-12-01
Decreased hippocampal N-acetylaspartate in the absence of atrophy in posttraumatic stress disorder
40/100 ✓ Peer-reviewed Hippocampus size on brain scans Biological psychiatry
Key finding: N-acetyl asparate and creatine reductions imply that there are hippocampal abnormalities in posttraumatic stress disorder. +1 more finding
Full summary, score breakdown and related studies → Original source
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2001-12-01
MRI predictors of cognition in subcortical ischemic vascular disease and Alzheimer's disease
49/100 ✓ Peer-reviewed Hippocampus size on brain scans Neurology
Key finding: Subcortical lacunes were not related to cognitive measures independent of effects of other MRI variables. +2 more findings
Full summary, score breakdown and related studies → Original source
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2001-12-01
Attenuation of frontal asymmetry in pediatric posttraumatic stress disorder
36/100 ✓ Peer-reviewed Hippocampus size on brain scans Biological psychiatry
Key finding: Frontal lobe abnormalities may occur as a result of PTSD in children or, alternatively, be a risk factor for the development of the syndrome in this age group. +4 more findings
Full summary, score breakdown and related studies → Original source
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2001-12-01
Beta-amyloid, neuronal death and Alzheimer's disease
36/100 ✓ Peer-reviewed Disease mechanisms Current molecular medicine
Key finding: Most evidence indicates that amyloid precursor protein (APP) processing is central to the AD process. +2 more findings
Full summary, score breakdown and related studies → Original source
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2001-12-01
CNS invasion by CD14+/CD16+ peripheral blood-derived monocytes in HIV dementia: perivascular accumulation and reservoir of HIV infection
41/100 ✓ Peer-reviewed Inflammation and the immune system Journal of neurovirology
Key finding: This model suggests that events outside the CNS leading to monocyte activation initiate the process leading to HIV dementia. +3 more findings
Full summary, score breakdown and related studies → Original source
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2001-12-01
Impaired cognitive function and compliance with antihypertensive drugs in elderly: the Rotterdam Study
56/100 ✓ Peer-reviewed Long-term cohort studies Clinical pharmacology and therapeutics
Key finding: We studied compliance with antihypertensive treatment in elderly patients with cognitive impairment. +3 more findings
Full summary, score breakdown and related studies → Original source
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2001-12-01
A randomized, double-blind, placebo-controlled study of the efficacy and safety of donepezil in patients with Alzheimer's disease in the nursing home setting
66/100 ✓ Peer-reviewed Treatments Journal of the American Geriatrics Society
Key finding: Twenty-four-week, randomized, multicenter, parallel-group, double-blind, placebo-controlled trial. +3 more findings
Full summary, score breakdown and related studies → Original source
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2001-12-01
Molecular basis of neuroprotective activities of rasagiline and the anti-Alzheimer drug TV3326 [(N-propargyl-(3R)aminoindan-5-YL)-ethyl methyl carbamate]
39/100 ✓ Peer-reviewed Risk genes beyond APOE Cellular and molecular neurobiology
Key finding: In controlled monotherapy and as adjunct to L-dopa it has shown anti-Parkinson activity. +3 more findings
Full summary, score breakdown and related studies → Original source
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2001-12-01
Brain metabolism and brain disease: is metabolic deficiency the proximate cause of Alzheimer dementia?
40/100 ✓ Peer-reviewed Risk genes beyond APOE Journal of neuroscience research
Key finding: Deficiencies associated with disease are known in all the pathways of oxidative/energy metabolism and are associated with some of the most common disorders of the nervous system, including Alzheimer's disease (AD) and Parkinson's disease. +3 more findings
Full summary, score breakdown and related studies → Original source
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2001-12-01
Topography of projections from amygdala to bed nuclei of the stria terminalis
46/100 ✓ Peer-reviewed Lewy body dementia Brain research. Brain research reviews
Key finding: The results suggest three organizing principles of these connections. +3 more findings
Full summary, score breakdown and related studies → Original source
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2001-12-01
Frequency and distribution of TUNEL-positive neurons in brains of dementia with Lewy bodies: comparison with those in brains of Alzheimer's disease
27/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Neuropathology : official journal of the Japanese Society of Neuropathology
Key finding: In DLB brains, TUNEL-positive neurons were increased in frequency compared with those in non-demented elderly brains, and showed a distribution similar to those in AD and DS brains. +1 more finding
Full summary, score breakdown and related studies → Original source
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2001-12-01
Protein expression in Down syndrome brain
39/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Amino acids
Key finding: Down syndrome (DS) is the most common chromosomal abnormality associated with early mental retardation and neurological abnormalities followed by precocious age dependent Alzheimer-type neurode generation later in life.
Full summary, score breakdown and related studies → Original source
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2001-12-01
History of depression as a risk factor for dementia: an updated review
61/100 ✓ Peer-reviewed Risk factors The Australian and New Zealand journal of psychiatry
Key finding: The possibility that history of depression is a risk factor for dementia needs to be taken seriously and explanations of the association need to be further researched. +1 more finding
Full summary, score breakdown and related studies → Original source
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2001-12-01
Influence of leisure activity on the incidence of Alzheimer's disease
62/100 ✓ Peer-reviewed How common it is Neurology
Key finding: The data suggest that engagement in leisure activities may reduce the risk of incident dementia, possibly by providing a reserve that delays the onset of clinical manifestations of the disease. +3 more findings
Full summary, score breakdown and related studies → Original source
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2001-12-01
Cognition and survival: an exploration in a large multicentre study of the population aged 65 years and over
40/100 ✓ Peer-reviewed Disparities International journal of epidemiology
Key finding: Cognitive function appears to be a marker of capacity for survival in the UK.
Full summary, score breakdown and related studies → Original source
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2001-12-01
Delirium in mechanically ventilated patients: validity and reliability of the confusion assessment method for the intensive care unit (CAM-ICU)
72/100 ✓ Peer-reviewed Getting a diagnosis JAMA
Key finding: Compared with the reference standard for diagnosing delirium, 2 study nurses using the CAM-ICU had sensitivities of 100% and 93%, specificities of 98% and 100%, and high interrater reliability (kappa = 0.96; 95% confidence interval, 0.92-0.99). +2 more findings
Full summary, score breakdown and related studies → Original source
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2001-12-01
Current concepts in mild cognitive impairment
61/100 ✓ Peer-reviewed Getting a diagnosis Archives of neurology
Key finding: When these persons are observed longitudinally, they progress to clinically probable AD at a considerably accelerated rate compared with healthy age-matched individuals.
Full summary, score breakdown and related studies → Original source
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2001-12-01
Melatonin reverses the profibrillogenic activity of apolipoprotein E4 on the Alzheimer amyloid Abeta peptide
44/100 ✓ Peer-reviewed Genetics Biochemistry
Key finding: Several lines of evidence suggest that apoE4 binds to the Alzheimer Abeta protein and, under certain experimental conditions, promotes formation of beta-sheet structures and amyloid fibrils. +1 more finding
Full summary, score breakdown and related studies → Original source
November 2001 7
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2001-11-28
Vascular fibrosis and calcification in the hippocampus in aging, Alzheimer disease, and Down syndrome
48/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Acta neuropathologica
Key finding: Study of the hippocampal formation of 82 subjects, including 25 control subjects from 33 to 83 years of age, 34 subjects with Alzheimer disease (AD) from 65 to 89 years of age, and 23 subjects with Down syndrome (DS) from 33 to 72 years of age, revealed hippocampal vasculopathy with fibrosis and calcification (VFC) in 40% of control, 59% of AD, and 4% of DS subjects. +4 more findings
Full summary, score breakdown and related studies → Original source
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2001-11-27
A novel presenilin 2 gene mutation (D439A) in a patient with early-onset Alzheimer's disease
46/100 ✓ Peer-reviewed Risk genes beyond APOE Neurology
Key finding: Haplotype analysis indicated that his affected mother was the most probable mutation carrier.
Full summary, score breakdown and related studies → Original source
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2001-11 month only
Cerebrospinal fluid tau and beta-amyloid(1-42) in dementia disorders
38/100 ✓ Peer-reviewed Tau biomarkers Mechanisms of ageing and development
Key finding: The reliability of cerebrospinal fluid (CSF)-tau and CSF-beta-amyloid assays for diagnosis of Alzheimer's disease and other dementing disorders such as frontotemporal dementia (FTD), dementia with Lewy bodies (DLB) and Creutzfeldt-Jakob disease (CJD) is reviewed. +2 more findings
Full summary, score breakdown and related studies → Original source
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2001-11-01
Effects of a flexible galantamine dose in Alzheimer's disease: a randomised, controlled trial
56/100 ✓ Peer-reviewed Treatments Journal of neurology, neurosurgery, and psychiatry
Key finding: Patients on galantamine, compared with those on placebo, experienced benefits in cognitive function and instrumental and basic activities of daily living. +3 more findings
Full summary, score breakdown and related studies → Original source
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2001-11-01
The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling
36/100 ✓ Peer-reviewed Risk genes beyond APOE Progress in neurobiology
Key finding: GSK3beta has been linked to all of the primary abnormalities associated with Alzheimer's disease.
Full summary, score breakdown and related studies → Original source
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2001-11-01
Disability and mild cognitive impairment: a longitudinal population-based study
64/100 ✓ Peer-reviewed Cognitive tests and assessment International journal of geriatric psychiatry
Key finding: Difficulties in the performance of everyday activities were found more frequently in non-demented subjects with mild cognitive deficits than in the general population. +2 more findings
Full summary, score breakdown and related studies → Original source
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2001-11-01
Neurofilament protein in cerebrospinal fluid: a marker of white matter changes
36/100 ✓ Peer-reviewed Biomarkers Journal of neuroscience research
Key finding: A comparison between patients and controls with any signs of WMC and those without such signs yielded a similar result: CSF NFL (P < 0.001) was increased in the group with signs of WMC. +2 more findings
Full summary, score breakdown and related studies → Original source
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