Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 23,126–23,150 of 27,380 studies, newest first · page 926 of 1096.
June 2006 1
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2006-06-01
Frontotemporal dementia: clinicopathological correlations
55/100 ✓ Peer-reviewed Getting a diagnosis Annals of neurology
Key finding: Clinical and neuropsychological features contribute to delineating the spectrum of pathology underlying a patient diagnosed with FTLD, but biomarkers are needed that, together with the clinical phenotype, can predict the underlying neuropathology. +4 more findings
Full summary, score breakdown and related studies → Original source
May 2006 24
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2006-05-26
A meta-analysis of structural brain abnormalities in PTSD
64/100 ✓ Peer-reviewed Hippocampus size on brain scans Neuroscience and biobehavioral reviews
Key finding: This series of meta-analyses examined structural abnormalities of the hippocampus and other brain regions in persons with PTSD compared to trauma-exposed and non-exposed control groups. +4 more findings
Full summary, score breakdown and related studies → Original source
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2006-05-23
Tumor necrosis factor-alpha induces neurotoxicity via glutamate release from hemichannels of activated microglia in an autocrine manner
49/100 ✓ Peer-reviewed Inflammation and the immune system The Journal of biological chemistry
Key finding: In addition, tumor necrosis factor-alpha (TNF-alpha) secreted from activated microglia may elicit neurodegeneration through caspase-dependent cascades and silencing cell survival signals. +3 more findings
Full summary, score breakdown and related studies → Original source
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2006-05-23
Decreased RNA, and increased RNA oxidation, in ribosomes from early Alzheimer's disease
42/100 ✓ Peer-reviewed Mild cognitive impairment Neurochemical research
Key finding: Recent studies from our laboratory indicate that declines in protein synthesis and ribosome function occur in the earliest stage of Alzheimer's disease (AD). +1 more finding
Full summary, score breakdown and related studies → Original source
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2006-05-22
It's Time to March
31/100 ✓ Peer-reviewed Health systems and care delivery Journal of the American Geriatrics Society
Key finding: That word allows us to occupy the high moral ground but to no avail. +4 more findings
Full summary, score breakdown and related studies → Original source
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2006-05-19
HIV-1 associated dementia: symptoms and causes
40/100 ✓ Peer-reviewed Inflammation and the immune system Retrovirology
Key finding: This suggests that indirect mechanisms of neuronal injury and loss/death occur in HIV/AIDS as a basis for dementia since neurons are not themselves productively infected by HIV-1.
Full summary, score breakdown and related studies → Original source
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2006-05-19
Fat intake at midlife and risk of dementia and Alzheimer's disease: a population-based study
53/100 ✓ Peer-reviewed Prevention and risk Dementia and geriatric cognitive disorders
Key finding: Moderate intake of unsaturated fats at midlife is protective, whereas a moderate intake of saturated fats may increase the risk of dementia and AD, especially among ApoE epsilon4 carriers.
Full summary, score breakdown and related studies → Original source
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2006-05-18
ERK1/2 activation mediates Abeta oligomer-induced neurotoxicity via caspase-3 activation and tau cleavage in rat organotypic hippocampal slice cultures
36/100 ✓ Peer-reviewed Disease mechanisms The Journal of biological chemistry
Key finding: In this study, we investigated the molecular basis for the altered signal transduction associated with soluble amyloid beta-protein (Abeta) oligomer-mediated neurotoxicity in the hippocampus, which is primarily linked to cognitive dysfunction in Alzheimer disease (AD). +3 more findings
Full summary, score breakdown and related studies → Original source
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2006-05-15
Role of complement in neurodegeneration and neuroinflammation
46/100 ✓ Peer-reviewed Inflammation and the immune system Molecular immunology
Key finding: Although viewed for many years as an immune-privileged organ, the central nervous system contains many components of the immune system, including components of the complement system that are synthesized by astrocytes, microglia, and neurons. +3 more findings
Full summary, score breakdown and related studies → Original source
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2006-05-12
Cognitive abnormalities in post-traumatic stress disorder
36/100 ✓ Peer-reviewed Hippocampus size on brain scans Trends in cognitive sciences
Key finding: Characteristically arising in response to overwhelmingly terrifying events, post-traumatic stress disorder (PTSD) is a disorder of memory: sufferers seemingly relive their trauma in the form of involuntary recollection. +4 more findings
Full summary, score breakdown and related studies → Original source
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2006-05-11
NSAIDs and Alzheimer disease: epidemiological, animal model and clinical studies
49/100 ✓ Peer-reviewed Inflammation and the immune system Neurobiology of aging
Key finding: Activated microglia, along with a spectrum of inflammatory mediators, have been identified in association with the lesions of Alzheimer disease (AD), suggesting that antiinflammatory agents such as NSAIDs should protect against the disease. +3 more findings
Full summary, score breakdown and related studies → Original source
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2006-05-11
Helping caregivers of persons with dementia: which interventions work and how large are their effects?
64/100 ✓ Peer-reviewed Caregiving International psychogeriatrics
Key finding: Because most interventions have domain-specific outcomes, clinicians must tailor interventions according to the specific needs of the individual caregivers. +2 more findings
Full summary, score breakdown and related studies → Original source
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2006-05-06
Mechanisms of homocysteine neurotoxicity in neurodegenerative diseases with special reference to dementia
46/100 ✓ Peer-reviewed Risk factors FEBS letters
Key finding: Human studies suggest that homocysteine (Hcy) plays a role in brain damage, cognitive and memory decline.
Full summary, score breakdown and related studies → Original source
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2006-05-04
Progression to dementia in clinical subtypes of mild cognitive impairment
47/100 ✓ Peer-reviewed Mild cognitive impairment Dementia and geriatric cognitive disorders
Key finding: When the clinical syndrome of MCI evolves on a neurodegenerative basis, the multiple-domain type of MCI has a less favorable prognosis than the amnestic type and may represent a more advanced prodromal stage of dementia. +1 more finding
Full summary, score breakdown and related studies → Original source
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2006-05-04
Impact of behavioural problems on spousal caregivers: a comparison between Alzheimer's disease and frontotemporal dementia
45/100 ✓ Peer-reviewed Caregiving Dementia and geriatric cognitive disorders
Key finding: Caregivers of FTD patients were overall more distressed by the behaviour of their partners than were the caregivers of AD patients. +1 more finding
Full summary, score breakdown and related studies → Original source
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2006-05-02
Differences between Alzheimer's disease and dementia with Lewy bodies: an fMRI study of task-related brain activity
42/100 ✓ Peer-reviewed Brain scans and imaging Brain : a journal of neurology
Key finding: Reaction time or accuracy in DLB and Alzheimer's disease differed significantly from controls but not between patient groups, with the exception of accuracy in the face task (DLB < Alzheimer's disease; P = 0.038). +1 more finding
Full summary, score breakdown and related studies → Original source
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2006-05-01
The Lille apathy rating scale (LARS), a new instrument for detecting and quantifying apathy: validation in Parkinson's disease
45/100 ✓ Peer-reviewed Clinical safety Journal of neurology, neurosurgery, and psychiatry
Key finding: Standard validity indices showed that the LARS is sensitive and capable of distinguishing between apathy and depression. +1 more finding
Full summary, score breakdown and related studies → Original source
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2006-05-01
Quality of life of people with dementia in residential care homes
36/100 ✓ Peer-reviewed Health systems and care delivery The British journal of psychiatry : the journal of mental science
Key finding: The QoL-AD could be used as an effective measure of the quality of life of people with dementia in residential homes. +1 more finding
Full summary, score breakdown and related studies → Original source
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2006-05-01
S-nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration
41/100 ✓ Peer-reviewed Disease mechanisms Nature
Key finding: During neurodegenerative disorders and cerebral ischaemia, the accumulation of immature and denatured proteins results in ER dysfunction, but the upregulation of PDI represents an adaptive response to protect neuronal cells. +1 more finding
Full summary, score breakdown and related studies → Original source
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2006-05-01
Roles for NF-kappaB in nerve cell survival, plasticity, and disease
36/100 ✓ Peer-reviewed Disease mechanisms Cell death and differentiation
Key finding: Recent findings indicate that NF-kappaB plays important roles in disorders such as epilepsy, stroke, Alzheimer's and Parkinson's diseases, as well as oncogenesis.
Full summary, score breakdown and related studies → Original source
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2006-05-01
Depression and risk for Alzheimer disease: systematic review, meta-analysis, and metaregression analysis
64/100 ✓ Peer-reviewed Risk factors Archives of general psychiatry
Key finding: A history of depression may confer an increased risk for later developing AD. +2 more findings
Full summary, score breakdown and related studies → Original source
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2006-05-01
Nutrition in brain development and aging: role of essential fatty acids
36/100 ✓ Peer-reviewed Brain scans and imaging Nutrition reviews
Key finding: The fetus and placenta are dependent on maternal EFA supply for their growth and development, with docosahexaenomic acid (DHA)-supplemented infants showing significantly greater mental and psychomotor development scores (breast-fed children do even better). +1 more finding
Full summary, score breakdown and related studies → Original source
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2006-05-01
Falls as a complication of diabetes mellitus in older people
41/100 ✓ Peer-reviewed Clinical safety Journal of diabetes and its complications
Key finding: We provide evidence that poorly controlled diabetes and conditions associated with complications of diabetes are associated with an increased risk of falling in older people.
Full summary, score breakdown and related studies → Original source
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2006-05-01
Region-specific dissociation of neuronal loss and neurofibrillary pathology in a mouse model of tauopathy
36/100 ✓ Peer-reviewed Disease mechanisms The American journal of pathology
Key finding: We observed regional dissociation of neuronal loss and accumulation of neurofibrillary pathology, because there was loss of neurons before neurofibrillary lesions appeared in the dentate gyrus and, conversely, neurofibrillary pathology appeared without major cell loss in the striatum. +1 more finding
Full summary, score breakdown and related studies → Original source
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2006-05-01
Regulation of inducible nitric oxide synthase gene in glial cells
43/100 ✓ Peer-reviewed Inflammation and the immune system Antioxidants & redox signaling
Key finding: Resident glial cells in the CNS (astroglia and microglia) express inducible nitric oxide synthase (iNOS) and produce high levels of NO in response to a wide variety of proinflammatory and degenerative stimuli. +3 more findings
Full summary, score breakdown and related studies → Original source
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