Newest studies

Sleep disturbance in mild to moderate Alzheimer's disease

40/100 ✓ Peer-reviewed Risk factors Sleep medicine

Key finding: Sleep disturbance in AD is associated with other behavioural symptoms, notably aggressiveness. +3 more findings

• Lifestyle

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Proteins in human brain cortex are modified by oxidation, glycoxidation, and lipoxidation. Effects of Alzheimer disease and identification of lipoxidation targets

36/100 ✓ Peer-reviewed Disease mechanisms The Journal of biological chemistry

Key finding: Alzheimer disease was associated with significant, although heterogeneous, increases in the concentrations of all evaluated markers.

Full summary, score breakdown and related studies → Original source

Linkage disequilibrium fine mapping and haplotype association analysis of the tau gene in progressive supranuclear palsy and corticobasal degeneration

50/100 ✓ Peer-reviewed Disparities Journal of medical genetics

Key finding: The findings support the pathological evidence that underlying variations in MAPT could contribute to disease pathogenesis by subtle effects on gene expression and/or splicing. +3 more findings

• Genetics

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Combined 99mTc-ECD SPECT and neuropsychological studies in MCI for the assessment of conversion to AD

49/100 ✓ Peer-reviewed Mild cognitive impairment Neurobiology of aging

Key finding: Thirty-one MCI subjects underwent a clinical and neuropsychological examination, and a regional cerebral blood flow (rCBF) SPECT scan at baseline. +4 more findings

• Early Stage
• Brain Scans

Full summary, score breakdown and related studies → Original source

Characteristics of two distinct clinical phenotypes in pathologically proven progressive supranuclear palsy: Richardson's syndrome and PSP-parkinsonism

55/100 ✓ Peer-reviewed Getting a diagnosis Brain : a journal of neurology

Key finding: Disease duration in RS was significantly shorter (5.9 versus 9.1 years, P < 0.001) and age at death earlier (72.1 versus 75.5 years, P = 0.01) than in PSP-P. +4 more findings

• Genetics
• Other Dementias

Full summary, score breakdown and related studies → Original source

Diagnostic accuracy of mini-mental status examination and revised hasegawa dementia scale for Alzheimer's disease

40/100 ✓ Peer-reviewed Cognitive tests and assessment Dementia and geriatric cognitive disorders

Key finding: The area under the receiver operator curve (AUC) for AD of the HDS-R (AUC(HDS-R)) and MMSE (AUC(MMSE)) were bigger than 0.90 indicating that both tests are useful for detecting AD. +3 more findings

• Diagnosis

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Somatostatin regulates brain amyloid beta peptide Abeta42 through modulation of proteolytic degradation

52/100 ✓ Peer-reviewed Brain tissue and pathology Nature medicine

Key finding: A prominent decrease in this neuropeptide also represents a pathological characteristic of Alzheimer disease. +3 more findings

• Brain Biology

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P2Y2 nucleotide receptors enhance alpha-secretase-dependent amyloid precursor protein processing

43/100 ✓ Peer-reviewed Risk genes beyond APOE The Journal of biological chemistry

Key finding: Alternatively, APP can be cleaved within the amyloid beta domain by alpha-secretase releasing the non-amyloidogenic product sAPP alpha, which has been shown to have neuroprotective properties. +3 more findings

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Saccadic eye movement changes in Parkinson's disease dementia and dementia with Lewy bodies

50/100 ✓ Peer-reviewed Brain scans and imaging Brain

Key finding: PDD and DLB patients had similar impairment in all tasks (P > 0.05, not significant). +4 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

The 9 year cognitive decline before dementia of the Alzheimer type: a prospective population-based study

58/100 ✓ Peer-reviewed Getting a diagnosis Brain : a journal of neurology

Key finding: The results showed that cognitive performances of the pre-morbid subjects at baseline were already lower than those of individuals without dementia (1.4 points less on the Mini-Mental State Examination; 1.8 points less on the Benton Visual Retention Test; 4 points less on the Isaacs Set Test and 0.8 points less on the Wechsler Similarities Test). +1 more finding

• Diagnosis

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The apolipoprotein E epsilon4 allele increases the odds of chronic cerebral infarction [corrected] detected at autopsy in older persons

55/100 ✓ Peer-reviewed Genetics Stroke

Key finding: Subjects included 96 males and 118 females with a mean age at death of 86 years (SD, 7).

• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

19F and 1H MRI detection of amyloid beta plaques in vivo

58/100 ✓ Peer-reviewed Brain scans and imaging Nature neuroscience

Key finding: Our findings provide a new direction for specific noninvasive amyloid imaging without the danger of exposure to radiation. +1 more finding

• Brain Scans
• Brain Biology

Full summary, score breakdown and related studies → Original source

Deaths: leading causes for 2002

36/100 ✓ Peer-reviewed Disparities PubMed

Key finding: In 2002, the 10 leading causes of death were (in rank order) Diseases of heart; Malignant neoplasms; Cerebrovascular diseases; Chronic lower respiratory diseases; Accidents (unintentional injuries); Diabetes mellitus; Influenza and pneumonia; Alzheimer's disease; Nephritis, nephrotic syndrome and nephrosis; and Septicemia and accounted for about 79 percent of all deaths occurring in the United States. +3 more findings

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The low density lipoprotein receptor-related protein (LRP) is a novel beta-secretase (BACE1) substrate

49/100 ✓ Peer-reviewed Risk genes beyond APOE The Journal of biological chemistry

Key finding: After BACE cleavage, APP becomes a substrate for gamma-secretase, leading to release of amyloid-beta peptide (Abeta), which accumulates in senile plaques in Alzheimer disease. +3 more findings

Full summary, score breakdown and related studies → Original source

Role of oxidative carbonylation in protein quality control and senescence

36/100 ✓ Peer-reviewed Disease mechanisms The EMBO journal

Key finding: Such carbonylated aggregates can become cytotoxic and have been associated with a large number of age-related disorders, including Parkinson's disease, Alzheimer's disease, and cancer.

Full summary, score breakdown and related studies → Original source

Endosome function and dysfunction in Alzheimer's disease and other neurodegenerative diseases

36/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Neurobiology of aging

Key finding: Endocytosis is universally important in cell function. +4 more findings

• Down Syndrome
• Genetics

Full summary, score breakdown and related studies → Original source

Role of retinoid signalling in the adult brain

36/100 ✓ Peer-reviewed Prevention and risk Progress in neurobiology

Key finding: Components of the metabolic pathway for retinoids have been identified in adult brain tissues, suggesting that all-trans-retinoic acid (ATRA) can be synthesized in discrete regions of the brain. +2 more findings

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Beta-amyloid-stimulated microglia induce neuron death via synergistic stimulation of tumor necrosis factor alpha and NMDA receptors

36/100 ✓ Peer-reviewed Treatments The Journal of neuroscience : the official journal of the Society for Neuroscience

Key finding: Although abundant reactive microglia are found associated with beta-amyloid (Abeta) plaques in Alzheimer's disease (AD) brains, their contribution to cell loss remains speculative. +3 more findings

• Brain Biology

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Pattern of cerebral hypoperfusion in Alzheimer disease and mild cognitive impairment measured with arterial spin-labeling MR imaging: initial experience

36/100 ✓ Peer-reviewed Brain scans and imaging Radiology

Key finding: Arterial spin-labeling MR imaging showed regional hypoperfusion with AD, in brain regions similar to those seen in FDG PET and HMPAO SPECT studies of similar populations; this hypoperfusion persists after accounting for underlying cortical gray matter atrophy. +2 more findings

• Brain Scans
• Early Stage

Full summary, score breakdown and related studies → Original source

Executive function correlates with walking speed in older persons: the InCHIANTI study

43/100 ✓ Peer-reviewed Vascular contributions Journal of the American Geriatrics Society

Key finding: In nondemented older persons, executive function is independently associated with tasks of lower extremity function that require high attentional demand. +1 more finding

• Lifestyle

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A systematic review of the scientific evidence for the efficacy of a palliative care approach in advanced dementia

64/100 ✓ Peer-reviewed End-of-life care International psychogeriatrics

Key finding: Despite the increased interest in palliative care for patients with dementia there is currently little evidence on which to base such an approach.

• End-of-Life Care
• Clinical Trials

Full summary, score breakdown and related studies → Original source

Detecting depression in Alzheimer's disease: evaluation of four different scales

45/100 ✓ Peer-reviewed Cognitive tests and assessment Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists

Key finding: The prevalence of depressive symptoms depends on the severity of dementia and the instruments used. +3 more findings

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Importance of a comprehensive geriatric assessment in prediction of complications following thoracic surgery in elderly patients

46/100 ✓ Peer-reviewed Cognitive tests and assessment Chest

Key finding: The prevalence of comorbidities and functional impairment among elderly patients may enhance the risk of operation-related complications, but the importance of these conditions in elderly patients undergoing thoracic surgery remains unclear. +3 more findings

• Diagnosis

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Cognitive and functional neuroimaging correlate for anosognosia in mild cognitive impairment and Alzheimer's disease

47/100 ✓ Peer-reviewed Cognitive tests and assessment International journal of geriatric psychiatry

Key finding: From a prospective Memory Clinic cohort including consecutively referred patients, age 60 years or above, and with MMSE score 20 or above, 36 patients with AD and 30 with MCI were included in this study. +3 more findings

• Early Stage

Full summary, score breakdown and related studies → Original source

Quality of life in dementia--a one-year follow-up study

53/100 ✓ Peer-reviewed Cognitive tests and assessment International journal of geriatric psychiatry

Key finding: Quality of life (QoL) is becoming an increasingly used outcome measure in both clinical practice and research but little is known about QoL in dementia and how it may change over time. +3 more findings

Full summary, score breakdown and related studies → Original source