Newest studies

Normative data for the Montreal Cognitive Assessment in an Italian population sample

46/100 ✓ Peer-reviewed Getting a diagnosis Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

Key finding: Previous studies revealed that certain items of MoCA may be culturally biased and highlighted the need for population-based norms for the MoCA. +3 more findings

• Diagnosis

Full summary, score breakdown and related studies → Original source

Advance care planning in primary care, only for severely ill patients? A structured review

36/100 ✓ Peer-reviewed End-of-life care Family practice

Key finding: ACP does not seem to have a systematic place in the care for all community-dwelling older people.

• End-of-Life Care
• Care Services

Full summary, score breakdown and related studies → Original source

Transcranial direct current stimulation and cognitive training in the rehabilitation of Alzheimer disease: A case study

41/100 ✓ Peer-reviewed Prevention trials Neuropsychological rehabilitation

Key finding: Statistical analyses revealed that whereas the tDCS+CT condition had few effects on the CTs, it induced a stability of the patient's global cognitive functioning lasting approximately 3 months, which was not achieved when the patient underwent sham+CT condition. +1 more finding

Full summary, score breakdown and related studies → Original source

Conversion between mini-mental state examination, montreal cognitive assessment, and dementia rating scale-2 scores in Parkinson's disease

61/100 ✓ Peer-reviewed Cognitive tests and assessment Movement disorders : official journal of the Movement Disorder Society

Key finding: Thus, routine screening of global cognitive abilities is important for the optimal management of PD patients. +3 more findings

• Diagnosis
• Other Dementias

Full summary, score breakdown and related studies → Original source

Supportive CSF biomarker evidence to enhance the National Institute on Aging-Alzheimer's Association criteria for diagnosis of Alzheimer's type dementia--a study from Southern India

30/100 ✓ Peer-reviewed Tau biomarkers Asian journal of psychiatry

Key finding: A total of 20 subjects diagnosed clinically as Alzheimer's dementia according to the NIA-AA criteria for AD were included in the study. +3 more findings

• Biomarkers
• Diagnosis

Full summary, score breakdown and related studies → Original source

The burden of disease in older people and implications for health policy and practice

60/100 ✓ Peer-reviewed Caregiving Lancet (London, England)

Key finding: Primary prevention in adults aged younger than 60 years will improve health in successive cohorts of older people, but much of the potential to reduce disease burden will come from more effective primary, secondary, and tertiary prevention targeting older people. +4 more findings

• Policy

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The Value of Delaying Alzheimer's Disease Onset

40/100 ✓ Peer-reviewed Caregiving Forum for health economics & policy

Key finding: The value of medical advances that delay onset of AD could be significant. +3 more findings

• Prevention
• Policy

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Statin discontinuation in nursing home residents with advanced dementia

53/100 ✓ Peer-reviewed End-of-life care Journal of the American Geriatrics Society

Key finding: Most NH residents who use statins at the time of progression to advanced dementia continue use in follow-up. +4 more findings

• Care Services
• Risk Factors

Full summary, score breakdown and related studies → Original source

Shared decision-making in dementia: A review of patient and family carer involvement

41/100 ✓ Peer-reviewed Caregiving Dementia (London, England)

Key finding: This paper reviews empirical findings concerning the decision-making process of persons with dementia and their family carers, with a particular focus on the extent and determinants of involvement of persons with dementia in the decision-making process.

• Caregiving

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Autophagy of mitochondria: a promising therapeutic target for neurodegenerative disease

38/100 ✓ Peer-reviewed Disease mechanisms Cell biochemistry and biophysics

Key finding: The autophagic process is the only known mechanism for mitochondrial turnover and it has been speculated that dysfunction of autophagy may result in mitochondrial error and cellular stress. +3 more findings

• Brain Biology
• Treatments
• Other Dementias

Full summary, score breakdown and related studies → Original source

Fracture as an independent risk factor of dementia: a nationwide population-based cohort study

67/100 ✓ Peer-reviewed Digital health tools Medicine

Key finding: The overall incidence rate of dementia in individuals with fractures was 41% higher than that in individuals without fractures (6.05 vs 4.30 per 1000 person-years) at an adjusted hazard ratio of 1.38 (95% confidence interval 1.32-1.45) after age, sex, urbanization, and individual disorders or comorbidities were adjusted. +2 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Quebec Integrated Chronic Disease Surveillance System (QICDSS), an innovative approach

40/100 ✓ Peer-reviewed Digital health tools Chronic diseases and injuries in Canada

Key finding: The QICDSS provides a way of producing population-based data on the chronic disease burden, health services and prescription drug uses.

Full summary, score breakdown and related studies → Original source

Reactive oxygen species, heat stress and oxidative-induced mitochondrial damage. A review

36/100 ✓ Peer-reviewed Disease mechanisms International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group

Key finding: Heat stress was suggested to be an environmental factor responsible for stimulating ROS production because of similarities in responses observed following heat stress compared with that occurring following exposure to oxidative stress.

• Brain Biology

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Synergistic effect of β-amyloid and neurodegeneration on cognitive decline in clinically normal individuals

59/100 ✓ Peer-reviewed Brain scans and imaging JAMA neurology

Key finding: The co-occurrence of Aβ and ND accelerates cognitive decline in CN individuals. +3 more findings

• Brain Scans
• Early Stage

Full summary, score breakdown and related studies → Original source

Tau PET imaging in Alzheimer's disease

52/100 ✓ Peer-reviewed Brain scans and imaging Current neurology and neuroscience reports

Key finding: In several neurodegenerative diseases that are collectively called tauopathies, progressive accumulation of tau in the brain is closely associated with neurodegeneration and cognitive impairment.

• Brain Scans

Full summary, score breakdown and related studies → Original source

Use of medications of questionable benefit in advanced dementia

50/100 ✓ Peer-reviewed End-of-life care JAMA internal medicine

Key finding: Of 5406 nursing home residents with advanced dementia, 2911 (53.9%) received at least 1 medication with questionable benefit (range, 44.7% in the Mid-Atlantic census region to 65.0% in the West South Central census region). +2 more findings

• Treatments

Full summary, score breakdown and related studies → Original source

Treatment of frontotemporal dementia

44/100 ✓ Peer-reviewed Digital health tools Current treatment options in neurology

Key finding: Each syndrome can be associated with one or more underlying neuropathological diagnoses and are referred to as frontotemporal lobar degeneration (FTLD). +3 more findings

• Other Dementias
• Treatments

Full summary, score breakdown and related studies → Original source

Impact of sleep on the risk of cognitive decline and dementia

48/100 ✓ Peer-reviewed Prevention and risk Current opinion in psychiatry

Key finding: Trouble falling or staying asleep, poor sleep quality, and short or long sleep duration are gaining attention as potential risk factors for cognitive decline and dementia, including Alzheimer's disease. +1 more finding

• Lifestyle

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Genetic heterogeneity in Alzheimer disease and implications for treatment strategies

45/100 ✓ Peer-reviewed Genetics Current neurology and neuroscience reports

Key finding: Similar efforts are occurring in an extended Colombian family with a PSEN1 mutation, in APOE ε4 homozygotes, and in Down syndrome. +4 more findings

• Genetics
• Treatments

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Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study

72/100 ✓ Peer-reviewed Genetics JAMA neurology

Key finding: Analysis confirmed the association of APOE with earlier AAO (P = 3.3 × 10(-96)), with associations in CR1 (rs6701713, P = 7.2 × 10(-4)), BIN1 (rs7561528, P = 4.8 × 10(-4)), and PICALM (rs561655, P = 2.2 × 10(-3)) reaching statistical significance (P Conclusions and relevance We confirmed an association of APOE (OMIM 107741) variants with AAO among affected participants with LOAD and observed novel associations of CR1 (OMIM 120620), BIN1 (OMIM 601248), and PICALM (OMIM 603025) with AAO. +2 more findings

• Genetics

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APOE, MAPT, and SNCA genes and cognitive performance in Parkinson disease

57/100 ✓ Peer-reviewed Genetics JAMA neurology

Key finding: Our data indicate that the APOE ε4 allele is an important predictor of cognitive function in PD across multiple domains. +4 more findings

• Genetics

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Clinical Utility of Amyloid Imaging in a Complex Case of Corticobasal Syndrome Presenting with Psychiatric Symptoms

32/100 ✓ Peer-reviewed Biomarkers Journal of neurological disorders

Key finding: We report a 68-year-old female without past psychiatric history who was hospitalized for auditory hallucinations and persecutory delusions associated with cognitive and motor deficits. +2 more findings

• Brain Scans

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Motoric cognitive risk syndrome: Multicenter incidence study

70/100 ✓ Peer-reviewed Digital health tools Neurology

Key finding: The incidence of MCR is high in older adults. +1 more finding

• Risk Factors

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Biomarkers of Parkinson's disease: present and future

36/100 ✓ Peer-reviewed Costs and economics Metabolism: clinical and experimental

Key finding: Finally, the exposome concept is new in the biomarker discovery arena and it is suggested as a way to move forward in identifying biomarkers of neurological diseases. +4 more findings

• Biomarkers

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Fibrin deposited in the Alzheimer's disease brain promotes neuronal degeneration

43/100 ✓ Peer-reviewed Inflammation and the immune system Neurobiology of aging

Key finding: Besides the well-known pathologic characteristics, this disease also has a vascular component, and substantial evidence shows increased thrombosis as well as a critical role for fibrin(ogen) in AD. +3 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source