Newest studies

Alzheimer-like changes in rat models of spontaneous diabetes

44/100 ✓ Peer-reviewed Risk genes beyond APOE Diabetes

Key finding: Neuronal loss occurred in both models, significantly more so in type 2 diabetic BBZDR/Wor rats compared with type 1 diabetic BB/Wor rats and was associated with a ninefold increase of dystrophic neurites. +3 more findings

• Risk Factors

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Longitudinal MRI findings from the vitamin E and donepezil treatment study for MCI

63/100 ✓ Peer-reviewed Mild cognitive impairment Neurobiology of aging

Key finding: Although a non-significant trend toward slowing of hippocampal atrophy rates was seen in APOE is an element of 4 carriers treated with donepezil; no treatment effect was confirmed for any MRI measure in either treatment group. +1 more finding

• Treatments
• Early Stage
• Brain Scans

Full summary, score breakdown and related studies → Original source

Implementing routine cognitive screening of older adults in primary care: process and impact on physician behavior

45/100 ✓ Peer-reviewed Digital health tools Journal of general internal medicine

Key finding: Mini-Cog screening by office staff is feasible in primary care practice and has measurable effects on physician behavior. +1 more finding

• Diagnosis
• Care Services

Full summary, score breakdown and related studies → Original source

Delirium in older people

43/100 ✓ Peer-reviewed Costs and economics BMJ

Key finding: These are the unpleasant consequences of delirium—a common condition affecting ill older people, particularly those with some degree of dementia. +4 more findings

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Antipsychotics for delirium

67/100 ✓ Peer-reviewed Clinical safety The Cochrane database of systematic reviews

Key finding: Decrease in delirium scores were not significantly different comparing the effect of low dose haloperidol (< 3.0 mg per day) with the atypical antipsychotics olanzapine and risperidone (Odds ratio 0.63 (95% CI 10.29 - 1.38; p = 0.25). +4 more findings

• Side Effects

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Interventions for preventing delirium in hospitalised patients

69/100 ✓ Peer-reviewed Prevention and risk The Cochrane database of systematic reviews

Key finding: It is associated with increases in mortality, physical morbidity, length of hospital stay, institutionalisation and costs to healthcare providers. +3 more findings

• Prevention
• Care Services

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TDP-43 is deposited in the Guam parkinsonism-dementia complex brains

46/100 ✓ Peer-reviewed Brain tissue and pathology Brain : a journal of neurology

Key finding: In the present study, we carried out immunohistochemical and biochemical analyses of brains of Guamanians with the parkinsonism-dementia complex (G-PDC) using anti-TDP-43, anti-tau and anti-ubiquitin antibodies. +3 more findings

• Other Dementias
• Brain Biology

Full summary, score breakdown and related studies → Original source

Caring for a relative with dementia: family caregiver burden

51/100 ✓ Peer-reviewed Caregiving Journal of advanced nursing

Key finding: The results showed that 68.02% of caregivers were highly burdened and 65% exhibited depressive symptoms. +2 more findings

• Caregiving

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Outcome measures in clinical trials on medicinal products for the treatment of dementia: a European regulatory perspective

37/100 ✓ Peer-reviewed Treatments International psychogeriatrics

Key finding: Based on efficacy and safety data, several drugs have been approved for symptomatic improvement of dementia of the Alzheimer type and one for the symptomatic improvement of dementia associated with Parkinson's disease. +3 more findings

• Treatments
• Clinical Trials

Full summary, score breakdown and related studies → Original source

Comprehensive analysis of APOE and selected proximate markers for late-onset Alzheimer's disease: patterns of linkage disequilibrium and disease/marker association

44/100 ✓ Peer-reviewed Genetics Genomics

Key finding: The epsilon(4) allele of APOE confers a two- to fourfold increased risk for late-onset Alzheimer's disease (LOAD), but LOAD pathology does not all fit neatly around APOE. +2 more findings

• Genetics

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Familial Alzheimer disease-linked mutations specifically disrupt Ca2+ leak function of presenilin 1

45/100 ✓ Peer-reviewed Risk genes beyond APOE The Journal of clinical investigation

Key finding: In addition, a number of mutations in presenilin-1 (PS1) have been suggested to be associated with the occurrence of frontal temporal dementia (FTD). +3 more findings

• Genetics

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The Action to Control Cardiovascular Risk in Diabetes Memory in Diabetes Study (ACCORD-MIND): rationale, design, and methods

69/100 ✓ Peer-reviewed Treatments The American journal of cardiology

Key finding: The primary aim of the Action to Control Cardiovascular Risk in Diabetes (ACCORD) Memory in Diabetes Study (ACCORD-MIND) is to test whether there is a difference in the rate of cognitive decline and structural brain change in patients with diabetes treated with standard-care guidelines compared with those treated with intensive-care guidelines.

• Risk Factors
• Clinical Trials

Full summary, score breakdown and related studies → Original source

Tau aggregation and toxicity in a cell culture model of tauopathy

41/100 ✓ Peer-reviewed Tau biomarkers The Journal of biological chemistry

Key finding: Because appearance of tau-aggregate bearing lesions correlates with both cognitive decline and neurodegeneration, it has been hypothesized that tau aggregation may be directly toxic to cells that harbor them. +3 more findings

• Brain Biology

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Beta-amyloid imaging and memory in non-demented individuals: evidence for preclinical Alzheimer's disease

51/100 ✓ Peer-reviewed Brain scans and imaging Brain

Beta-amyloid (Abeta) deposition is pathognomic for Alzheimer's disease (AD), but may occur in normal elderly people without apparent cognitive effect.

• Brain Scans
• Early Stage
• Brain Biology

Full summary, score breakdown and related studies → Original source

Pathophysiology of REM sleep behaviour disorder and relevance to neurodegenerative disease

66/100 ✓ Peer-reviewed Risk factors Brain : a journal of neurology

Key finding: Neuroimaging data from the few published human cases with RBD associated with structural lesions in the brainstem are presented, in which the dorsal midbrain and pons are implicated. +3 more findings

• Lifestyle

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Bilateral hippocampal volume increase in patients with bipolar disorder and short-term lithium treatment

36/100 ✓ Peer-reviewed Hippocampus size on brain scans Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

Key finding: There was a bilateral increase in volumes of HC and Hh in the Li-treated group compared to the unmedicated group, an effect that was apparent even over a brief treatment period.

• Brain Scans
• Treatments

Full summary, score breakdown and related studies → Original source

Efficacy and safety of galantamine in patients with dementia with Lewy bodies: a 24-week open-label study

44/100 ✓ Peer-reviewed Cognitive tests and assessment Dementia and geriatric cognitive disorders

Key finding: Galantamine appears to be an effective and safe therapy for patients with DLB. +1 more finding

• Clinical Trials
• Other Dementias
• Treatments

Full summary, score breakdown and related studies → Original source

Cognitive disorders in acute stroke: prevalence and clinical determinants

51/100 ✓ Peer-reviewed Vascular contributions Cerebrovascular diseases (Basel, Switzerland)

Key finding: Cognitive impairment is common in the first weeks after stroke, with executive and perceptual disorders being the most frequent. +2 more findings

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Association of ambulatory blood pressure with ischemic brain injury

42/100 ✓ Peer-reviewed Disparities Hypertension (Dallas, Tex. : 1979)

Key finding: Cerebral white matter hyperintensities on brain MRI (leukoaraiosis) are associated with increased risk of stroke and dementia. +4 more findings

• Risk Factors
• Health Equity
• Brain Scans

Full summary, score breakdown and related studies → Original source

Risk Factors for Nursing Home Placement in Older Adults With and Without Dementia

36/100 ✓ Peer-reviewed Costs and economics Journal of Aging and Health

Key finding: Cox proportional hazard regressions indicated that baseline characteristics including older age, White race, diabetes, incontinence, stroke, and difficulties with instrumental activities increased risk of NHP in those without dementia. +4 more findings

• Risk Factors

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Neural basis of category-specific semantic deficits for living things: evidence from semantic dementia, HSVE and a neural network model

40/100 ✓ Peer-reviewed Digital health tools Brain : a journal of neurology

Key finding: When the semantic representations within the model are degraded or 'dimmed' then a generalized, global semantic impairment results (as found in SD) but when the representations are distorted then a category-specific pattern emerges (as per HSVE).

• Digital Tools

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An estimate of the total worldwide societal costs of dementia in 2005

40/100 ✓ Peer-reviewed Caregiving Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Worldwide costs for dementia are enormous, and informal care constitutes a major cost component, in particular in less developed regions. +1 more finding

• Policy

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Lithium and risk for Alzheimer's disease in elderly patients with bipolar disorder

50/100 ✓ Peer-reviewed Drug development The British journal of psychiatry : the journal of mental science

Key finding: Bipolar disorder is associated with increased risk for dementia. +1 more finding

• Treatments

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11C-PIB PET imaging in Alzheimer disease and frontotemporal lobar degeneration

47/100 ✓ Peer-reviewed Brain scans and imaging Neurology

Key finding: PET imaging with (11)C-labeled Pittsburgh Compound-B ((11)C-PIB) helps discriminate Alzheimer disease (AD) from frontotemporal lobar degeneration (FTLD). +1 more finding

• Brain Scans
• Other Dementias

Full summary, score breakdown and related studies → Original source

A high-density whole-genome association study reveals that APOE is the major susceptibility gene for sporadic late-onset Alzheimer's disease

41/100 ✓ Peer-reviewed Genetics The Journal of clinical psychiatry

Key finding: This study provides empirical support for the suggestion that the APOE locus is the major susceptibility gene for late-onset AD in the human genome, with an OR significantly greater than any other locus in the human genome. +4 more findings

• Genetics

Full summary, score breakdown and related studies → Original source