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Neural basis of category-specific semantic deficits for living things: evidence from semantic dementia, HSVE and a neural network model
Lambon Ralph MA, Lowe C, Rogers TT.. Brain : a journal of neurology, 2007-04-01
Topic: Brain imaging, connectivity and assessment
Studies of patients with semantic impairments following brain damage offer key insights into the cognitive and neural organization of semantic memory. Especially important in this regard are studies of category-specific semantic impairment. We report a direct comparison of semantic deficits in two groups suffering from different diseases: semantic dementia (SD) and herpes simplex virus encephalitis (HSVE). Although pathology in both disorders is centred on the anterior temporal lobes bilaterally, category-specific semantic impairment is rarely observed in SD yet commonly found in HSVE. Using a combination of neuropsychology and computational neuroscience, we tested the possibility that category-specific deficits for living things depend not solely upon the location of damage within the cortical semantic network but also critically upon the type of impairment. When the semantic representations within the model are degraded or 'dimmed' then a generalized, global semantic impairment results (as found in SD) but when the representations are distorted then a category-specific pattern emerges (as per HSVE). Three novel predictions from this model were tested and confirmed, thereby adding weight to the hypothesis that both type and distribution of pathology can be critical in producing neuropsychological phenomena.
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APA 7th
Lambon Ralph, M. A., Lowe, C., & Rogers, T. T. (2007). Neural basis of category-specific semantic deficits for living things: evidence from semantic dementia, HSVE and a neural network model. Brain : a journal of neurology. https://doi.org/10.1093/brain/awm025
Vancouver
Lambon Ralph MA, Lowe C, Rogers TT. Neural basis of category-specific semantic deficits for living things: evidence from semantic dementia, HSVE and a neural network model. Brain : a journal of neurology. 2007. doi:10.1093/brain/awm025. PMID: 17438021.
BibTeX
@article{lambonralph2007-17438021,
author = {Lambon Ralph, M. A. and Lowe, C. and Rogers, T. T.},
title = {{Neural basis of category-specific semantic deficits for living things: evidence from semantic dementia, HSVE and a neural network model}},
journal = {Brain : a journal of neurology},
year = {2007},
doi = {10.1093/brain/awm025},
pmid = {17438021},
url = {https://doi.org/10.1093/brain/awm025}
}
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Key findings
- When the semantic representations within the model are degraded or 'dimmed' then a generalized, global semantic impairment results (as found in SD) but when the representations are distorted then a category-specific pattern emerges (as per HSVE).
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Study details
- Evidence strengthLow
How this study scored 40/100
Published in a leading specialty journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 23 of the 58 points we could judge it on, which is 40 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Brain : a journal of neurology) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2007 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 17438021) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 23 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 23 of the 58 points we could judge it on is 40 out of 100. |
| Total | 40 / 100 | — |
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