Newest studies

Donepezil: an update

36/100 ✓ Peer-reviewed Treatments Expert Opinion on Pharmacotherapy

Key finding: Officially approved for mild-to-moderate and severe AD, donepezil has also been shown to be effective in early-stage AD, vascular dementia, Parkinson's disease dementia/Lewy body disease and cognitive symptoms associated with multiple sclerosis. +1 more finding

• Treatments
• Other Dementias

Full summary, score breakdown and related studies → Original source

Inflammatory markers and the risk of Alzheimer disease: the Framingham Study

40/100 ✓ Peer-reviewed Long-term cohort studies Neurology

Key finding: Higher spontaneous production of interleukin 1 or tumor necrosis factor alpha by peripheral blood mononuclear cells may be a marker of future risk of Alzheimer disease (AD) in older individuals. +1 more finding

• Risk Factors
• Brain Biology

Full summary, score breakdown and related studies → Original source

A prognostic model for 1-year mortality in older adults after hospital discharge

40/100 ✓ Peer-reviewed Digital health tools The American journal of medicine

Key finding: Reasonable prognostic information for 1-year mortality in older patients discharged from general medicine services can be derived from administrative data to identify high-risk groups of persons. +1 more finding

• Care Services

Full summary, score breakdown and related studies → Original source

Lithium reduces tau phosphorylation but not A beta or working memory deficits in a transgenic model with both plaques and tangles

36/100 ✓ Peer-reviewed Drug development The American journal of pathology

Key finding: In addition to the latter's well-described role in the phosphorylation of tau, reports also suggest that GSK-3 alpha may regulate amyloid precursor protein processing and Abeta formation. +2 more findings

• Brain Biology
• Treatments

Full summary, score breakdown and related studies → Original source

A six-month double-blind, randomized, placebo-controlled study of a transdermal patch in Alzheimer's disease--rivastigmine patch versus capsule

74/100 ✓ Peer-reviewed Treatments International journal of geriatric psychiatry

Key finding: The target dose of 10 cm2 rivastigmine patch provides efficacy similar to the highest doses of capsules with a superior tolerability profile. +1 more finding

• Clinical Trials
• Treatments

Full summary, score breakdown and related studies → Original source

Retinal abnormalities in early Alzheimer's disease

43/100 ✓ Peer-reviewed Brain scans and imaging Investigative ophthalmology & visual science

Key finding: Retinal abnormalities in early AD include a specific pattern of RNFL loss, narrow veins, and decreased retinal blood flow in these veins. +4 more findings

Full summary, score breakdown and related studies → Original source

Medicaid’s Prior Authorization Program And Access To Atypical Antipsychotic Medications

38/100 ✓ Peer-reviewed Health systems and care delivery Health Affairs

Key finding: State Medicaid programs use prior authorization (PA) to control drug spending by requiring that specific conditions be met before allowing reimbursement. +4 more findings

• Policy
• Treatments
• Side Effects

Full summary, score breakdown and related studies → Original source

Pathological TDP-43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutations

63/100 ✓ Peer-reviewed Brain tissue and pathology Annals of neurology

Key finding: Amyotrophic lateral sclerosis (ALS) is a common, fatal motor neuron disorder with no effective treatment. +3 more findings

• Genetics
• Brain Biology
• Other Dementias

Full summary, score breakdown and related studies → Original source

Atherosclerosis and risk for dementia

64/100 ✓ Peer-reviewed Long-term cohort studies Annals of neurology

Key finding: Atherosclerosis has been implicated in the development of dementia and its major subtypes, Alzheimer's disease and vascular dementia. +3 more findings

Full summary, score breakdown and related studies → Original source

CIND and MCI in the Italian elderly: frequency, vascular risk factors, progression to dementia

58/100 ✓ Peer-reviewed Mild cognitive impairment Neurology

Key finding: Both cognitive impairment, no dementia and mild cognitive impairment are frequent in the Italian elderly (2,955,000 prevalent cases expected) and significantly predict progression to dementia. +2 more findings

• Early Stage
• Risk Factors

Full summary, score breakdown and related studies → Original source

Predictors of progression from mild cognitive impairment to Alzheimer disease

60/100 ✓ Peer-reviewed Mild cognitive impairment Neurology

Key finding: The predictive validity of mild cognitive impairment (MCI) for identifying future Alzheimer disease (AD) cases is improved in the presence of anxiety symptoms.

• Early Stage

Full summary, score breakdown and related studies → Original source

TDP-43 immunoreactivity in hippocampal sclerosis and Alzheimer's disease

56/100 ✓ Peer-reviewed Lewy body dementia Annals of neurology

Key finding: These results suggest that as many as 20% of AD cases and more than 70% of HpScl cases have pathology similar to that found in FTLD-U. Whether this represents concomitant FTLD-U or is analogous to colocalization of alpha-synuclein and tau in AD, reflecting a propensity for codeposition of abnormal protein conformers, remains to be determined. +4 more findings

• Brain Biology
• Other Dementias

Full summary, score breakdown and related studies → Original source

Emotional impact of dementia diagnosis: exploring persons with dementia and caregivers' perspectives

42/100 ✓ Peer-reviewed Caregiving Aging & mental health

Key finding: Patients exhibited a range of emotional responses which can be divided into three broad categories: (a) responses suggesting a lack of insight and/or an active denial of the diagnosis, (b) grief reactions/emotional crisis related to the experience of actual or anticipated losses associated with dementia, and (c) positive coping responses to maximize the disease outcome.

• Caregiving
• Diagnosis

Full summary, score breakdown and related studies → Original source

The Montreal Cognitive Assessment: validity and utility in a memory clinic setting

50/100 ✓ Peer-reviewed Getting a diagnosis Canadian journal of psychiatry. Revue canadienne de psychiatrie

Key finding: The MoCA is a useful brief screening tool for the detection of mild dementia or MCI in subjects scoring over 25 points on the MMSE.

• Diagnosis
• Care Services

Full summary, score breakdown and related studies → Original source

Blood-brain barrier impairment in Alzheimer disease: stability and functional significance

49/100 ✓ Peer-reviewed Genetics Neurology

Key finding: Blood-brain barrier (BBB) impairment is a stable characteristic over 1 year and present in an important subgroup of patients with Alzheimer disease. +1 more finding

• Brain Biology

Full summary, score breakdown and related studies → Original source

PET amyloid ligand [11C]PIB uptake is increased in mild cognitive impairment

54/100 ✓ Peer-reviewed Genetics Neurology

Key finding: The SPM analysis showed that patients with MCI had significantly higher [(11)C]PIB uptake vs control subjects in the frontal, parietal, and lateral temporal cortices as well as in the posterior cingulate showing the most prominent differences. +3 more findings

• Early Stage
• Brain Scans

Full summary, score breakdown and related studies → Original source

Synaptic alterations in CA1 in mild Alzheimer disease and mild cognitive impairment

54/100 ✓ Peer-reviewed Genetics Neurology

Key finding: These results strongly support the concept that synapse loss is a structural correlate involved very early in cognitive decline in mild Alzheimer disease (mAD) and supports mild cognitive impairment as a transitional stage between mAD and no cognitive impairment. +1 more finding

• Brain Biology
• Early Stage
• Genetics

Full summary, score breakdown and related studies → Original source

Imaging beta-amyloid burden in aging and dementia

66/100 ✓ Peer-reviewed Genetics Neurology

Key finding: Pittsburgh Compound B PET findings match histopathologic reports of beta-amyloid (Abeta) distribution in aging and dementia. +1 more finding

• Genetics
• Brain Scans
• Early Stage

Full summary, score breakdown and related studies → Original source

Atomic structures of amyloid cross-beta spines reveal varied steric zippers

41/100 ✓ Peer-reviewed Brain tissue and pathology Nature

Key finding: Amyloid fibrils formed from different proteins, each associated with a particular disease, contain a common cross-beta spine. +2 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Recovery of learning and memory is associated with chromatin remodelling

41/100 ✓ Peer-reviewed Brain scans and imaging Nature

Key finding: Neurodegenerative diseases of the central nervous system are often associated with impaired learning and memory, eventually leading to dementia. +2 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

The stress system in depression and neurodegeneration: focus on the human hypothalamus

36/100 ✓ Peer-reviewed Risk factors Brain research reviews

Key finding: Increased levels of circulating AVP are also associated with the risk for suicide.

Full summary, score breakdown and related studies → Original source

Internalized antibodies to the Abeta domain of APP reduce neuronal Abeta and protect against synaptic alterations

43/100 ✓ Peer-reviewed Risk genes beyond APOE The Journal of biological chemistry

Key finding: Experimental studies in transgenic mouse models of AD have demonstrated that Abeta immunization reduces Abeta plaque pathology and improves cognitive function. +3 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Alkalizing drugs induce accumulation of amyloid precursor protein by-products in luminal vesicles of multivesicular bodies

47/100 ✓ Peer-reviewed Risk genes beyond APOE The Journal of biological chemistry

Key finding: We showed recently that the amyloid intracellular domain (AICD), which is released by gamma-secretase cleavage of APP C-terminal fragments (CTFs), is strongly increased in cells treated with alkalizing drugs (Vingtdeux, V., Hamdane, M., Bégard, S., Loyens, A., Delacourte, A., Beauvillain, J.-C., Buée, L., Marambaud, P., and Sergeant, N. +3 more findings

• Treatments

Full summary, score breakdown and related studies → Original source

The effects of stress and stress hormones on human cognition: Implications for the field of brain and cognition

36/100 ✓ Peer-reviewed Hippocampus size on brain scans Brain and cognition

Key finding: Here, we summarize the cases that led to the diagnosis of glucocorticoid-induced 'steroid psychosis' in human populations and which demonstrated that these stress hormones could thus cross the blood-brain barrier and access the brain where they could influence cognition and mental health. +2 more findings

Full summary, score breakdown and related studies → Original source

Naproxen and celecoxib do not prevent AD in early results from a randomized controlled trial

71/100 ✓ Peer-reviewed Treatments Neurology

Key finding: These results do not support the hypothesis that celecoxib or naproxen prevent Alzheimer dementia, at least within the early years after initiation of treatment. +1 more finding

• Clinical Trials
• Diagnosis
• Prevention

Full summary, score breakdown and related studies → Original source