Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 21,376–21,400 of 27,380 studies, newest first · page 856 of 1096.
July 2009 19
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2009-07-01
Different cognitive profiles for single compared with recurrent fallers without dementia
45/100 ✓ Peer-reviewed Clinical safety Neuropsychology
Key finding: Relationships between self-reported retrospective falls and cognitive measures (executive function, reaction time [RT], processing speed, working memory, visual attention) were examined in a population based sample of older adults (n = 658).
Full summary, score breakdown and related studies → Original source
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2009-07-01
Pyroglutamate formation influences solubility and amyloidogenicity of amyloid peptides
36/100 ✓ Peer-reviewed Clinical safety Biochemistry
Key finding: The far-UV CD spectroscopic analysis points toward an enhanced beta-sheet structure of the pGlu-Abeta. +4 more findings
Full summary, score breakdown and related studies → Original source
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2009-07-01
Tangle-bearing neurons survive despite disruption of membrane integrity in a mouse model of tauopathy
36/100 ✓ Peer-reviewed Disease mechanisms Journal of neuropathology and experimental neurology
Key finding: Neurofibrillary tangles (NFTs) are associated with neuronal loss and correlate with cognitive impairment in Alzheimer disease, but how NFTs relate to neuronal death is not clear. +2 more findings
Full summary, score breakdown and related studies → Original source
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2009-07-01
Presenilins are essential for regulating neurotransmitter release
45/100 ✓ Peer-reviewed Disease mechanisms Nature
Key finding: Moreover, we found that presynaptic but not postsynaptic inactivation of presenilins alters short-term plasticity and synaptic facilitation. +1 more finding
Full summary, score breakdown and related studies → Original source
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2009-07-01
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2009-07-01
Longitudinal modeling of age-related memory decline and the APOE epsilon4 effect
70/100 ✓ Peer-reviewed Brain tissue and pathology The New England journal of medicine
Key finding: The APOE epsilon4 allele is associated with the risk of late-onset Alzheimer's disease. +3 more findings
Full summary, score breakdown and related studies → Original source
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2009-07-01
Mild cognitive impairment in rapid eye movement sleep behavior disorder and Parkinson's disease
51/100 ✓ Peer-reviewed Risk factors Annals of neurology
Key finding: In both its association with PD and its idiopathic form, RBD is an important risk factor for MCI. +1 more finding
Full summary, score breakdown and related studies → Original source
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2009-07-01
Non-Fluent Speech in Frontotemporal Lobar Degeneration
49/100 ✓ Peer-reviewed Digital health tools Journal of neurolinguistics
Key finding: PNFA patients were significantly less fluent than controls and other FTLD patients. +2 more findings
Full summary, score breakdown and related studies → Original source
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2009-07-01
Chronic traumatic encephalopathy in athletes: progressive tauopathy after repetitive head injury
53/100 ✓ Peer-reviewed Digital health tools Journal of neuropathology and experimental neurology
Key finding: Since the 1920s, it has been known that the repetitive brain trauma associated with boxing may produce a progressive neurological deterioration, originally termed dementia pugilistica, and more recently, chronic traumatic encephalopathy (CTE). +1 more finding
Full summary, score breakdown and related studies → Original source
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2009-07-01
Alcohol consumption as a risk factor for dementia and cognitive decline: meta-analysis of prospective studies
73/100 ✓ Peer-reviewed How common it is The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
Key finding: The pooled relative risks (RRs) of AD, VaD, and Any dementia for light to moderate drinkers compared with nondrinkers were 0.72 (95% CI = 0.61-0.86), 0.75 (95% CI = 0.57-0.98), and 0.74 (95% CI = 0.61-0.91), respectively. +3 more findings
Full summary, score breakdown and related studies → Original source
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2009-07-01
Dementia in the acute hospital: prospective cohort study of prevalence and mortality
68/100 ✓ Peer-reviewed How common it is The British journal of psychiatry : the journal of mental science
Key finding: The rising prevalence of dementia will have an impact on acute hospitals.
Full summary, score breakdown and related studies → Original source
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2009-07-01
Superficial siderosis in the general population
62/100 ✓ Peer-reviewed Brain scans and imaging Neurology
Key finding: Our results provide further indirect support for the presumed link between superficial siderosis and cerebral amyloid angiopathy (CAA). +1 more finding
Full summary, score breakdown and related studies → Original source
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2009-07-01
MRI and CSF biomarkers in normal, MCI, and AD subjects: diagnostic discrimination and cognitive correlations
60/100 ✓ Peer-reviewed Brain scans and imaging Neurology
Key finding: We found no significant correlation between CSF biomarkers and cognitive scores in any of the 3 clinical groups individually. +1 more finding
Full summary, score breakdown and related studies → Original source
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2009-07-01
MRI and CSF biomarkers in normal, MCI, and AD subjects: predicting future clinical change
61/100 ✓ Peer-reviewed Brain scans and imaging Neurology
Key finding: MRI and CSF provide complimentary predictive information about time to conversion from amnestic mild cognitive impairment to Alzheimer disease and combination of the 2 provides better prediction than either source alone. +2 more findings
Full summary, score breakdown and related studies → Original source
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2009-07-01
Drugs with anticholinergic properties, cognitive decline, and dementia in an elderly general population: the 3-city study
53/100 ✓ Peer-reviewed Getting a diagnosis Archives of internal medicine
Key finding: Elderly people taking anticholinergic drugs were at increased risk for cognitive decline and dementia. +4 more findings
Full summary, score breakdown and related studies → Original source
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2009-07-01
CSF biomarkers and incipient Alzheimer disease in patients with mild cognitive impairment
75/100 ✓ Peer-reviewed Getting a diagnosis JAMA
Key finding: During follow-up, 271 participants with MCI were diagnosed with AD and 59 with other dementias. +1 more finding
Full summary, score breakdown and related studies → Original source
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2009-07-01
Angiotensin-converting enzyme inhibitors and cognitive decline in older adults with hypertension: results from the Cardiovascular Health Study
59/100 ✓ Peer-reviewed Prevention and risk Archives of internal medicine
Key finding: These results should be confirmed with a randomized clinical trial of a centrally active ACE inhibitor in the prevention of cognitive decline and dementia. +4 more findings
Full summary, score breakdown and related studies → Original source
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2009-07-01
Efficacy of rivastigmine for cognitive symptoms in Parkinson disease with dementia
55/100 ✓ Peer-reviewed Treatments The neurologist
Key finding: Rivastigmine therapy for PDD is associated with significant tradeoffs in efficacy and adverse effects. +4 more findings
Full summary, score breakdown and related studies → Original source
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2009-07-01
Characteristics and performance of a modified version of the ADCS-CGIC CIBIC+ for mild cognitive impairment clinical trials
42/100 ✓ Peer-reviewed Treatments Alzheimer disease and associated disorders
Key finding: Change detected by the MCI-CGIC was associated with baseline clinical severity and with change in clinical ratings over 6 and 12 months, supporting the validity of a CGIC approach in MCI. +4 more findings
Full summary, score breakdown and related studies → Original source
June 2009 6
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2009-06-30
Change in Blood Pressure and Incident Dementia
43/100 ✓ Peer-reviewed Drug development Hypertension
Key finding: In an analysis of 1890 men who completed all 6 of the exams, 112 diagnosed with incident dementia at examination 6 were compared with the 1778 survivors without dementia. +2 more findings
Full summary, score breakdown and related studies → Original source
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2009-06-30
Impairment of synaptic plasticity and memory formation in GLP-1 receptor KO mice: Interaction between type 2 diabetes and Alzheimer's disease
36/100 ✓ Peer-reviewed Drug development Behavioural brain research
Key finding: Previous studies have shown that the incretin glucagon-like peptide 1 (GLP-1) helps to normalise insulin signalling in type 2 diabetes. +2 more findings
Full summary, score breakdown and related studies → Original source
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2009-06-30
Greater than the sum of its parts: a review of studies combining structural connectivity and resting-state functional connectivity
36/100 ✓ Peer-reviewed Brain scans and imaging Brain structure & function
Key finding: All studies examined show largely convergent results: the strength of resting-state functional connectivity is positively correlated with structural connectivity strength.
Full summary, score breakdown and related studies → Original source
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2009-06-30
Elevated basal cortisol level predicts lower hippocampal volume and cognitive decline in Alzheimer's disease
45/100 ✓ Peer-reviewed Hippocampus size on brain scans Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
Key finding: Basal plasma cortisol levels increased with age. +4 more findings
Full summary, score breakdown and related studies → Original source
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2009-06-28
Age-associated cerebral atrophy in mouse lemur primates
41/100 ✓ Peer-reviewed Brain scans and imaging Neurobiology of aging
Key finding: Cross-sectional analysis suggests that the atrophy follows a gradual pathway, starting in the frontal region then involving the temporal and/or the parietal part of the brain and finally the occipital region. +2 more findings
Full summary, score breakdown and related studies → Original source
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2009-06-27
Dementia and life expectancy: what do we know?
64/100 ✓ Peer-reviewed End-of-life care Journal of the American Medical Directors Association
Key finding: Despite much data, we lack a unifying guideline for dementia prognostication.
Full summary, score breakdown and related studies → Original source
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