Newest studies

Three methods of assessing values for advance care planning: comparing persons with and without dementia

36/100 ✓ Peer-reviewed End-of-life care Journal of aging and health

Key finding: Responses to forced-choice items were examined at 9-month retest. +4 more findings

• End-of-Life Care

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Quetiapine to treat agitation in dementia: a randomized, double-blind, placebo-controlled study

74/100 ✓ Peer-reviewed Clinical safety Current Alzheimer research

Key finding: Compared with placebo, quetiapine 200mg/day was associated with clinically greater improvements in PANSS-EC (LOCF, p=0.065; OC, p=0.014 [ANCOVA]), CGI-C (LOCF, p=0.017; OC, p=0.002 [ANOVA]), and CGI-C response rates (LOCF, p=0.002; OC, p<0.001 [Chi-square test]). +1 more finding

• Clinical Trials
• Side Effects

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Recognizing delirium superimposed on dementia: assessing nurses' knowledge using case vignettes

36/100 ✓ Peer-reviewed Clinical safety Journal of gerontological nursing

Key finding: Delirium is a serious and prevalent problem that occurs in many hospitalized older adults.

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Association between psychomotor activity delirium subtypes and mortality among newly admitted post-acute facility patients

62/100 ✓ Peer-reviewed Clinical safety The journals of gerontology. Series A, Biological sciences and medical sciences

Key finding: All three psychomotor disturbance subtypes had an elevated risk of dying during the 1-year follow-up relative to the normal psychomotor group, though the hypoactive group had the highest mortality risk and was the only group with a statistically significantly elevated risk relative to the normal group. +1 more finding

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Presynaptic alpha-synuclein aggregates, not Lewy bodies, cause neurodegeneration in dementia with Lewy bodies

36/100 ✓ Peer-reviewed Disease mechanisms The Journal of neuroscience : the official journal of the Society for Neuroscience

Key finding: Indeed, parallel to the massive presynaptic accumulation of alpha-synuclein aggregates, we observed significant synaptic pathology with almost complete loss of dendritic spines at the postsynaptic area. +1 more finding

• Other Dementias
• Brain Biology

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Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model

58/100 ✓ Peer-reviewed Disease mechanisms Neuron

Key finding: Hippocampal synapse loss and impaired synaptic function were detected in 3 month old P301S Tg mice before fibrillary tau tangles emerged. +2 more findings

• Brain Biology

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TDP-43 in the ubiquitin pathology of frontotemporal dementia with VCP gene mutations

49/100 ✓ Peer-reviewed Brain tissue and pathology Journal of neuropathology and experimental neurology

Key finding: The CNS pathology is characterized by a novel pattern of ubiquitin pathology distinct from sporadic and familial frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U) without VCP mutations. +3 more findings

• Genetics
• Brain Biology
• Other Dementias

Full summary, score breakdown and related studies → Original source

Arterial stiffness, cognitive decline, and risk of dementia: the Rotterdam study

53/100 ✓ Peer-reviewed Long-term cohort studies Stroke

Key finding: Vascular factors and stroke are associated with cognitive function and dementia. +3 more findings

• Risk Factors

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Ethnic and educational differences in cognitive test performance on mini-mental state examination in Asians

51/100 ✓ Peer-reviewed Cognitive tests and assessment The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

Key finding: There were significant ethnic differences in mean MMSE scores among Chinese (26.2), Indians (25.0), and Malays (23.6), but only in noneducated subjects. +3 more findings

• Diagnosis
• Health Equity

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Loss-of-function presenilin mutations in Alzheimer disease. Talking Point on the role of presenilin mutations in Alzheimer disease

49/100 ✓ Peer-reviewed Risk genes beyond APOE EMBO reports

Key finding: From a genetic point of view, these mutations seem to result in a gain of toxic function; however, biochemically, they result in a partial loss of function in the gamma-secretase complex, which affects several downstream signalling pathways. +3 more findings

• Genetics

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Mild cognitive impairment: current research and clinical implications

45/100 ✓ Peer-reviewed Mild cognitive impairment Seminars in neurology

Key finding: Clinical guidelines, including the original memory-focused criteria and the more recent broadly defined set of criteria, will be presented. +4 more findings

• Early Stage

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Tracking Alzheimer's disease

48/100 ✓ Peer-reviewed Mild cognitive impairment Annals of the New York Academy of Sciences

Key finding: A complementary technique, TBM, reveals the 3D profile of atrophic rates, at each point in the brain. +4 more findings

• Early Stage
• Brain Scans

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Increased level of active GSK-3beta in Alzheimer's disease and accumulation in argyrophilic grains and in neurones at different stages of neurofibrillary degeneration

44/100 ✓ Peer-reviewed Lewy body dementia Neuropathology and applied neurobiology

Key finding: By Western blotting analysis, a significant increase in the level of GSK-3 (pTyr216) was observed in the frontal cortex of AD patients. +1 more finding

• Brain Biology

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Dementia and neurocognitive disorders due to HIV-1 infection

40/100 ✓ Peer-reviewed Caregiving Seminars in neurology

Key finding: HIV-associated neurocognitive impairment is a significant burden to persons living with HIV infection, caregivers, and the health care system. +1 more finding

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Strategic subcortical hyperintensities in cholinergic pathways and executive function decline in treated Alzheimer patients

55/100 ✓ Peer-reviewed Brain scans and imaging Archives of neurology

Key finding: Cerebrovascular compromise of the cholinergic pathways may be a factor that contributes more selectively than does total white matter lesion burden to response to cholinergic therapy in Alzheimer disease, particularly on frontal/executive tasks. +2 more findings

• Brain Scans

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Loneliness and risk of Alzheimer disease

69/100 ✓ Peer-reviewed Getting a diagnosis Archives of general psychiatry

Key finding: Loneliness is associated with an increased risk of late-life dementia but not with its leading causes. +4 more findings

• Risk Factors
• Lifestyle

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The application of proteomics and genomics to the study of age-related neurodegeneration and neuroprotection

37/100 ✓ Peer-reviewed Biomarkers Antioxidants & redox signaling

Key finding: Furthermore, the neurofilament light peptide, associated with neurodegenerative processes, was enhanced and binding/ chaperone proteins were altered in old vs. young rats. +2 more findings

• Genetics

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Selenium level and cognitive function in rural elderly Chinese

50/100 ✓ Peer-reviewed Disparities American journal of epidemiology

Key finding: Selenium is a trace element associated with antioxidant activity and is considered to be a protective agent against free radicals through enhanced enzyme activity. +4 more findings

• Health Equity

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Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis

41/100 ✓ Peer-reviewed Brain scans and imaging Nature

Key finding: Together, our results suggest that Dll4-Notch1 signalling between the endothelial cells within the angiogenic sprout serves to restrict tip-cell formation in response to VEGF, thereby establishing the adequate ratio between tip and stalk cells required for correct sprouting and branching patterns. +1 more finding

• Genetics

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Regional coherence changes in the early stages of Alzheimer's disease: a combined structural and resting-state functional MRI study

36/100 ✓ Peer-reviewed Brain scans and imaging NeuroImage

Key finding: Recent functional imaging studies have indicated that the pathophysiology of Alzheimer's disease (AD) can be associated with the changes in spontaneous low-frequency (<0.08 Hz) blood oxygenation level-dependent fluctuations (LFBF) measured during a resting state. +4 more findings

• Brain Scans

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FAD mutants unable to increase neurotoxic Abeta 42 suggest that mutation effects on neurodegeneration may be independent of effects on Abeta

36/100 ✓ Peer-reviewed Biomarkers Journal of neurochemistry

Key finding: Our data suggest that the mechanism by which FAD mutations promote neurodegeneration and AD may be independent of their effects on Abeta production.

• Genetics

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Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide

53/100 ✓ Peer-reviewed Disease mechanisms Nature Reviews Molecular Cell Biology

Key finding: Small intermediates - soluble oligomers - in the aggregation process can confer synaptic dysfunction, whereas large, insoluble deposits might function as reservoirs of the bioactive oligomers. +2 more findings

• Brain Biology

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Phenotypic variation in a large Swedish pedigree due to SNCA duplication and triplication

52/100 ✓ Peer-reviewed Brain tissue and pathology Neurology

Key finding: The "Lister family complex," an extensive Swedish family with autosomal dominant Parkinson disease, was first described by Henry Mjönes in 1949. +3 more findings

• Brain Scans

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Intraneuronal Abeta immunoreactivity is not a predictor of brain amyloidosis-beta or neurofibrillary degeneration

50/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Acta neuropathologica

Key finding: The absence or detection of only traces of reaction with antibodies against 4-13 aa and 8-17 aa of Abeta in neurons indicated that intraneuronal Abeta was mainly a product of alpha- and gamma-secretases (Abeta(17-40/42)). +3 more findings

• Brain Biology

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Quantitative gait dysfunction and risk of cognitive decline and dementia

66/100 ✓ Peer-reviewed How common it is Journal of neurology, neurosurgery, and psychiatry

Key finding: Our findings indicate that quantitative gait measures predict future risk of cognitive decline and dementia in initially non-demented older adults. +3 more findings

• Risk Factors

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