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Beta-amyloid imaging and memory in non-demented individuals: evidence for preclinical Alzheimer's disease
Kerryn Elizabeth Pike, Greg R. Savage, Victor L. Villemagne, S. Ng, Simon Andrew Moss, Paul T. Maruff, Chester A. Mathis, William E. Klunk, Colin Louis Masters, Christopher C. Rowe. Brain, 2007-04-05
Topic: Amyloid, tau and blood-test diagnosis
Beta-amyloid (Abeta) deposition is pathognomic for Alzheimer's disease (AD), but may occur in normal elderly people without apparent cognitive effect. Episodic memory impairment is an early and prominent sign of AD, but its relationship with Abeta burden in non-demented persons and in AD patients is unclear. We examined this relationship using 11C-PIB-PET as a quantitative marker of Abeta burden in vivo in healthy ageing (HA), mild cognitive impairment (MCI) and AD. Thirty-one AD, 33 MCI and 32 HA participants completed neuropsychological assessment and a 11C-PIB-PET brain scan. Multiple linear regression analyses were conducted relating episodic memory performance and other cognitive functions to Abeta burden. Ninety-seven percent of AD, 61% of MCI and 22% of HA cases had increased cortical PIB binding, indicating the presence of Abeta plaques. There was a strong relationship between impaired episodic memory performance and PIB binding, both in MCI and HA. This relationship was weaker in AD and less robust for non-memory cognitive domains. Abeta deposition in the asymptomatic elderly is associated with episodic memory impairment. This finding, together with the strong relationship between PIB binding and the severity of memory impairment in MCI, suggests that individuals with increased cortical PIB binding are on the path to Alzheimer's disease. The data also suggests that early intervention trials for AD targeted to non-demented individuals with cerebral Abeta deposition are warranted.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Pike, K. E., Savage, G. R., Villemagne, V. L., Ng, S., Moss, S. A., Maruff, P. T., et al. (2007). Beta-amyloid imaging and memory in non-demented individuals: evidence for preclinical Alzheimer's disease. Brain. https://doi.org/10.1093/brain/awm238
Vancouver
Pike KE, Savage GR, Villemagne VL, Ng S, Moss SA, Maruff PT, et al. Beta-amyloid imaging and memory in non-demented individuals: evidence for preclinical Alzheimer's disease. Brain. 2007. doi:10.1093/brain/awm238.
BibTeX
@article{pike2007-fae1d136,
author = {Pike, Kerryn Elizabeth and Savage, Greg R. and Villemagne, Victor L. and Ng, S. and Moss, Simon Andrew and Maruff, Paul T. and Mathis, Chester A. and Klunk, William E. and Masters, Colin Louis and Rowe, Christopher C.},
title = {{Beta-amyloid imaging and memory in non-demented individuals: evidence for preclinical Alzheimer's disease}},
journal = {Brain},
year = {2007},
doi = {10.1093/brain/awm238},
url = {https://doi.org/10.1093/brain/awm238}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 10 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Why it matters
In 31 people with Alzheimer's disease, 33 with mild cognitive impairment and 32 healthy older adults scanned with PIB PET, increased amyloid binding was found in 97%, 61% and 22% respectively. Amyloid was strongly related to poorer episodic memory in mild cognitive impairment and in healthy older adults, which the authors suggest marks people on the path to Alzheimer's disease.
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How this study scored 51/100
Published in a leading specialty journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on strength of evidence, so that was left out: it earned 48 of the 95 points we could judge it on, which is 51 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Brain) |
| Journal's citation record | 4 / 4 | Brain: journal h-index 503 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | — / 5 | No evidence rating recorded — left out of this score |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2007 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 6 / 7 | Cited 791 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 37.7 citations a year over 21 year(s) since 2007 |
| Impact for its field and year | 5 / 6 | Cited 33.6× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 2 / 4 | Cited 24 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 1 / 4 | Last-listed author Christopher C. Rowe: h-index 5 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | University of Pittsburgh: institution h-index 1,470 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 5 institution(s) in 2 countries |
| Indexed in PubMed | 1 / 2 | Not in PubMed, but has a DOI |
| Free to read | 2 / 2 | Free to read |
| Points | 48 / 95 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 48 of the 95 points we could judge it on is 51 out of 100. |
| Total | 51 / 100 | — |
What each of these 20 components measures, and what this score is not →
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