Newest studies

Appeals System and Its Outcomes in National Health Insurance in Taiwan

41/100 ✓ Peer-reviewed Health systems and care delivery Annals of Pharmacotherapy

Key finding: A total of 12,237 cases of donepezil and 6975 cases of rivastigmine were submitted to the BNHI for prior authorization; among them, 72.6% of donepezil and 66.5% of rivastigmine cases received authorization. +4 more findings

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Loss of expectation-related mechanisms in Alzheimer's disease makes analgesic therapies less effective

55/100 ✓ Peer-reviewed Brain scans and imaging Pain

Key finding: We found that AD patients with reduced Frontal Assessment Battery scores showed reduced placebo component of the analgesic treatment. +1 more finding

• Treatments

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Effects of secreted oligomers of amyloid beta-protein on hippocampal synaptic plasticity: a potent role for trimers

36/100 ✓ Peer-reviewed Disease mechanisms The Journal of physiology

Key finding: We have shown that small soluble oligomers of human Abeta that are naturally secreted by cultured cells inhibit hippocampal long-term potentiation (LTP) in vitro and in vivo and transiently impair the recall of a complex learned behaviour in rats. +3 more findings

• Brain Biology

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Changes in hippocampal connectivity in the early stages of Alzheimer's disease: evidence from resting state fMRI

43/100 ✓ Peer-reviewed Brain scans and imaging NeuroImage

Key finding: Here, we employ a resting state functional MRI (fMRI) to examine changes in hippocampal connectivity comparing 13 patients with mild AD versus 13 healthy age-matched controls. +2 more findings

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IPA survey of brief cognitive screening instruments

46/100 ✓ Peer-reviewed Risk factors International psychogeriatrics

Key finding: The majority of respondents were geriatric psychiatrists (58%). +1 more finding

• Diagnosis

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Leisure activities and the risk of amnestic mild cognitive impairment in the elderly

67/100 ✓ Peer-reviewed Prevention trials Neurology

Key finding: Cognitive activity participation is associated with lower risk of development of amnestic mild cognitive impairment, even after excluding individuals at early stages of dementia. +3 more findings

• Early Stage

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Hippocampal cytogenesis correlates to escitalopram-mediated recovery in a chronic mild stress rat model of depression

36/100 ✓ Peer-reviewed Hippocampus size on brain scans Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

Key finding: Conversely, preclinical studies have shown that chronic antidepressant treatment increases hippocampal neurogenesis. +2 more findings

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Redox proteomics identification of oxidatively modified hippocampal proteins in mild cognitive impairment: insights into the development of Alzheimer's disease

48/100 ✓ Peer-reviewed Mild cognitive impairment Neurobiology of disease

Key finding: Oxidative stress plays a significant role in AD and is increased in the superior/middle temporal gyri of MCI subjects. +3 more findings

• Early Stage

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Molecular structure of amyloid fibrils: insights from solid-state NMR

36/100 ✓ Peer-reviewed Brain tissue and pathology Quarterly Reviews of Biophysics

Key finding: References 46 Solid-state nuclear magnetic resonance (NMR) measurements have made major contributions to our understanding of the molecular structures of amyloid fibrils, including fibrils formed by the β-amyloid peptide associated with Alzheimer's disease, by proteins associated with fungal prions, and by a variety of other polypeptides.

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Course and outcomes of depression in the elderly

38/100 ✓ Peer-reviewed Risk factors Current psychiatry reports

Key finding: There is growing evidence that suggests that late-life depression may carry a higher illness burden than depression with onset earlier in life, and that severity is linked to medical and psychiatric comorbidity. +1 more finding

• Treatments

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The effect of emergency department crowding on the management of pain in older adults with hip fracture

55/100 ✓ Peer-reviewed Health systems and care delivery Journal of the American Geriatrics Society

Key finding: Older adults with hip fracture are at risk for underassessment of pain, considerable delays in analgesic administration after pain is identified, and treatment with inappropriate analgesics (e.g., meperidine) in the ED. +2 more findings

• Care Services

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Increased hippocampal plaques and tangles in patients with Alzheimer disease with a lifetime history of major depression

43/100 ✓ Peer-reviewed Health systems and care delivery Archives of general psychiatry

Key finding: In AD, the presence of a lifetime history of depression corresponds to increases in AD-related neuropathological changes within the hippocampus. +3 more findings

• Brain Biology

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Neurotrophin signalling in health and disease

36/100 ✓ Peer-reviewed Risk factors Clinical science (London, England : 1979)

Key finding: NGF (nerve growth factor), BDNF (brain-derived neurotrophic factor), NT-3 (neurotrophin-3) and NT-4 (neurotrophin-4) also mediate additional higher-order activities, such as learning, memory and behaviour, in addition to their established functions for cell survival. +4 more findings

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Paradigm shift in neuroprotection by NMDA receptor blockade: memantine and beyond

36/100 ✓ Peer-reviewed Treatments Nature reviews. Drug discovery

Key finding: Neuroprotective drugs tested in clinical trials, particularly those that block N-methyl-D-aspartate-sensitive glutamate receptors (NMDARs), have failed miserably in large part because of intolerable side effects. +2 more findings

• Treatments

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Hippocampal and amygdala volumes according to psychosis stage and diagnosis: a magnetic resonance imaging study of chronic schizophrenia, first-episode psychosis, and ultra-high-risk individuals

53/100 ✓ Peer-reviewed Hippocampus size on brain scans Archives of general psychiatry

Key finding: Patients with chronic schizophrenia displayed bilateral hippocampal volume reduction. +3 more findings

• Brain Scans

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Introduction of a pain scale for palliative care patients with cognitive impairment

45/100 ✓ Peer-reviewed End-of-life care International journal of palliative nursing

Key finding: Approximately half of the care providers evaluated both scales as being good measures of pain and easy to use.

• End-of-Life Care

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Occurrence and treatment of suspected pneumonia in long-term care residents dying with advanced dementia

55/100 ✓ Peer-reviewed End-of-life care Journal of the American Geriatrics Society

Key finding: Pneumonia is a common terminal event in advanced dementia for which many patients receive parenteral antibiotics. +3 more findings

• End-of-Life Care
• Treatments
• Care Services

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Multicomponent geriatric intervention for elderly inpatients with delirium: a randomized, controlled trial

74/100 ✓ Peer-reviewed Clinical safety The journals of gerontology. Series A, Biological sciences and medical sciences

Key finding: Faster alleviation of delirium and improved cognition justify good, comprehensive geriatric care for these patients although treatment produced no significant improvements in hard endpoints of prognosis. +3 more findings

• Clinical Trials

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Bone Marrow-Derived Microglia Play a Critical Role in Restricting Senile Plaque Formation in Alzheimer's Disease

55/100 ✓ Peer-reviewed Inflammation and the immune system Neuron

• Brain Biology

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Inflammation and neurodegenerative diseases

45/100 ✓ Peer-reviewed Inflammation and the immune system The American journal of clinical nutrition

Key finding: Recent work suggests that the activation of microglia in response to injury, illness, aging, or other causes begins a cascade of events that can best be characterized as an inflammatory process. +3 more findings

• Brain Biology

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Perspectives on depression, mild cognitive impairment, and cognitive decline

50/100 ✓ Peer-reviewed Brain tissue and pathology Archives of general psychiatry

Key finding: Cognitive impairment and late-life depression are associated with increased risk for subsequent dementia; however, investigations of these phenomena appear to be proceeding along separate tracks. +3 more findings

• Early Stage

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Association of white matter hyperintensity volume with decreased cognitive functioning: the Framingham Heart Study

49/100 ✓ Peer-reviewed Long-term cohort studies Archives of neurology

Key finding: Quantitative magnetic resonance imaging and neuropsychological evaluations were performed in 1820 dementia- and stroke-free participants from the Framingham Offspring Cohort. +3 more findings

• Brain Scans

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Anaemia increases the risk of dementia in cognitively intact elderly

58/100 ✓ Peer-reviewed Cognitive tests and assessment Neurobiology of aging

Key finding: We hypothesize that anaemia might increase the risk of developing dementia because of chronic brain hypo-oxygenation. +3 more findings

• Risk Factors

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Impairment of activities of daily living requiring memory or complex reasoning as part of the MCI syndrome

42/100 ✓ Peer-reviewed Cognitive tests and assessment International journal of geriatric psychiatry

Key finding: Mild Cognitive Impairment (MCI) is a borderline state between age-associated cognitive decline and mild dementia. +3 more findings

• Early Stage

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Mapping scores onto stages: mini-mental state examination and clinical dementia rating

52/100 ✓ Peer-reviewed Cognitive tests and assessment The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

Key finding: Although the clinical course of Alzheimer disease (AD) is gradual, it is useful for a number of reasons to distinguish between different levels of severity. +3 more findings

• Diagnosis

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