Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 20,126–20,150 of 27,380 studies, newest first · page 806 of 1096.
May 2011 25
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2011-05-09
A systematic review of different models of home and community care services for older persons
67/100 ✓ Peer-reviewed Health systems and care delivery BMC health services research
Key finding: The outcomes of each model of care differ and correspond to the model's focus. +4 more findings
Full summary, score breakdown and related studies → Original source
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2011-05-09
Risk factors and preventive interventions for Alzheimer disease: state of the science
55/100 ✓ Peer-reviewed Prevention trials Archives of neurology
Key finding: Currently, insufficient evidence exists to draw firm conclusions on the association of any modifiable factors with risk of AD. +1 more finding
Full summary, score breakdown and related studies → Original source
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2011-05-09
Comparison of analytical platforms for cerebrospinal fluid measures of β-amyloid 1-42, total tau, and p-tau181 for identifying Alzheimer disease amyloid plaque pathology
56/100 ✓ Peer-reviewed Brain scans and imaging Archives of neurology
Key finding: The INNOTEST and INNO-BIA CSF platforms perform equally well in identifying individuals with underlying amyloid plaque pathology. +1 more finding
Full summary, score breakdown and related studies → Original source
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2011-05-06
β-carboline compounds, including harmine, inhibit DYRK1A and tau phosphorylation at multiple Alzheimer's disease-related sites
40/100 ✓ Peer-reviewed Down syndrome and Alzheimer's PloS one
Key finding: We and others have implicated DYRK1A in the phosphorylation of tau protein on multiple sites associated with tau pathology in Down Syndrome and in Alzheimer's disease (AD). +1 more finding
Full summary, score breakdown and related studies → Original source
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2011-05-06
Alzheimer's disease markers, hypertension, and gray matter damage in normal elderly
40/100 ✓ Peer-reviewed Biomarkers Neurobiology of aging
Key finding: It is not well known whether Alzheimer's disease (AD) cerebrospinal fluid (CSF) biomarkers are associated with brain damage in cognitively normal elderly. +3 more findings
Full summary, score breakdown and related studies → Original source
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2011-05-06
The effect of comorbidity burden on health care utilization for patients with cancer using hospice
60/100 ✓ Peer-reviewed End-of-life care Journal of palliative medicine
Key finding: These findings underscore the complexity of the hospice patient population and highlight a potential need to risk adjust the per diem hospice reimbursement rates to account for increased resource requirements for hospices serving patients with higher comorbidity burden. +3 more findings
Full summary, score breakdown and related studies → Original source
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2011-05-04
Complement in the brain
36/100 ✓ Peer-reviewed Digital health tools Molecular immunology
Key finding: As a result, the detection and clearance of invading microorganisms and senescent cells as well as surplus neurotransmitters, aged and glycated proteins, in order to maintain a healthy environment for neuronal and glial cells, is largely confined to the innate immune system. +2 more findings
Full summary, score breakdown and related studies → Original source
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2011-05-03
Decision-making and outcomes of feeding tube insertion: a five-state study
41/100 ✓ Peer-reviewed End-of-life care Journal of the American Geriatrics Society
Key finding: Based on the perceptions of bereaved family members, important opportunities exist to improve decision-making in feeding tube insertion. +2 more findings
Full summary, score breakdown and related studies → Original source
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2011-05-03
Depression and risk of developing dementia
54/100 ✓ Peer-reviewed How common it is Nature reviews. Neurology
Key finding: In particular, earlier-life depression (or depressive symptoms) has consistently been associated with a more than twofold increase in dementia risk.
Full summary, score breakdown and related studies → Original source
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2011-05 month only
More good news about the magic ion: lithium may prevent dementia
38/100 ✓ Peer-reviewed Drug development The British journal of psychiatry : the journal of mental science
Key finding: Lithium is an established treatment for affective disorders with good evidence of antisuicidal properties. +2 more findings
Full summary, score breakdown and related studies → Original source
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2011-05-01
Soluble Aβ oligomers inhibit long-term potentiation through a mechanism involving excessive activation of extrasynaptic NR2B-containing NMDA receptors
36/100 ✓ Peer-reviewed Disease mechanisms The Journal of neuroscience : the official journal of the Society for Neuroscience
Key finding: We examined field EPSPs and whole-cell recordings in wild-type mouse hippocampal slices. +4 more findings
Full summary, score breakdown and related studies → Original source
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2011-05-01
Disease-modifying properties of long-term lithium treatment for amnestic mild cognitive impairment: randomised controlled trial
72/100 ✓ Peer-reviewed Drug development The British journal of psychiatry : the journal of mental science
Key finding: The present data support the notion that lithium has disease-modifying properties with potential clinical implications in the prevention of Alzheimer's disease. +1 more finding
Full summary, score breakdown and related studies → Original source
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2011-05-01
Mutations in DNMT1 cause hereditary sensory neuropathy with dementia and hearing loss
43/100 ✓ Peer-reviewed Genetics Nature genetics
Key finding: Exome sequencing led to the identification of DNMT1 mutation c.1484A>G (p.Tyr495Cys) in two American kindreds and one Japanese kindred and a triple nucleotide change, c.1470-1472TCC>ATA (p.Asp490Glu-Pro491Tyr), in one European kindred. +4 more findings
Full summary, score breakdown and related studies → Original source
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2011-05-01
Boosting brain uptake of a therapeutic antibody by reducing its affinity for a transcytosis target
36/100 ✓ Peer-reviewed Risk genes beyond APOE Science translational medicine
Key finding: Anti-TfR antibodies that bind with high affinity to TfR remain associated with the BBB, whereas lower-affinity anti-TfR antibody variants are released from the BBB into the brain and show a broad distribution 24 hours after dosing. +2 more findings
Full summary, score breakdown and related studies → Original source
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2011-05-01
FTD and ALS: a tale of two diseases
41/100 ✓ Peer-reviewed Brain tissue and pathology Current Alzheimer research
Key finding: Over the last 150 years, and especially in the last two decades, there has been growing evidence that FTD signs can be seen in patients primarily diagnosed with ALS, implying clinical overlap among these two disorders. +3 more findings
Full summary, score breakdown and related studies → Original source
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2011-05-01
Brain oligomeric β-amyloid but not total amyloid plaque burden correlates with neuronal loss and astrocyte inflammatory response in amyloid precursor protein/tau transgenic mice
45/100 ✓ Peer-reviewed Risk genes beyond APOE Journal of neuropathology and experimental neurology
Key finding: An alternative hypothesis is that soluble oligomers ofAβ play a much larger role in neuronal damage than the insoluble component. +3 more findings
Full summary, score breakdown and related studies → Original source
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2011-05-01
Etiology and pathogenesis of Parkinson's disease
49/100 ✓ Peer-reviewed Lewy body dementia Movement disorders : official journal of the Movement Disorder Society
Key finding: Based on the actions of toxins, postmortem investigations, and gene defects responsible for familial Parkinson's disease, there is now a general consensus about the mechanisms of cell death that contribute to neuronal loss in Parkinson's disease. +4 more findings
Full summary, score breakdown and related studies → Original source
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2011-05-01
Lewy- and Alzheimer-type pathologies in Parkinson's disease dementia: which is more important?
59/100 ✓ Peer-reviewed Lewy body dementia Brain : a journal of neurology
Key finding: Cortical and striatal amyloid-β scores, Braak tau stages, cortical Lewy body, Lewy neurite scores and Lewy body densities, but not Braak α-synuclein stages, were all significantly greater in the Parkinson's disease-dementia group (P<0.05), with all the pathologies showing a significant positive correlation to each other (P<0.05). +2 more findings
Full summary, score breakdown and related studies → Original source
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2011-05-01
Parkinson's disease: the quintessential neuropsychiatric disorder
50/100 ✓ Peer-reviewed Risk factors Movement disorders : official journal of the Movement Disorder Society
Key finding: In addition to the most commonly studied disorders of dementia, depression, and psychosis, other relatively common and clinically significant psychiatric complications include impulse control disorders, anxiety symptoms, disorders of sleep and wakefulness, and apathy.
Full summary, score breakdown and related studies → Original source
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2011-05-01
Midlife overweight and obesity increase late-life dementia risk: a population-based twin study
71/100 ✓ Peer-reviewed Risk factors Neurology
Key finding: Both overweight and obesity at midlife independently increase the risk of dementia, AD, and VaD. +2 more findings
Full summary, score breakdown and related studies → Original source
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2011-05-01
Incidence of and risk factors for dementia in the Ibadan study of aging
50/100 ✓ Peer-reviewed Disparities Journal of the American Geriatrics Society
Key finding: At 3-year follow-up, 85 participants had developed dementia. +3 more findings
Full summary, score breakdown and related studies → Original source
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2011-05-01
Telephone-based identification of mild cognitive impairment and dementia in a multicultural cohort
61/100 ✓ Peer-reviewed Disparities Archives of neurology
Key finding: The TICS has high diagnostic validity for identification of dementia among ethnically diverse older adults, especially when supported by the DQ and prior visit data. +1 more finding
Full summary, score breakdown and related studies → Original source
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2011-05-01
Executive function and instrumental activities of daily living in mild cognitive impairment and Alzheimer's disease
58/100 ✓ Peer-reviewed Getting a diagnosis Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: This relationship was evident even after accounting for degree of memory deficit across the continuum of cognitive impairment and dementia. +1 more finding
Full summary, score breakdown and related studies → Original source
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2011-05-01
Diet and Alzheimer's disease risk factors or prevention: the current evidence
41/100 ✓ Peer-reviewed Prevention and risk Expert review of neurotherapeutics
Key finding: Poorer cognitive function and an increased risk of vascular dementia (VaD) were found to be associated with a lower consumption of milk or dairy products. +4 more findings
Full summary, score breakdown and related studies → Original source
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2011-05-01
Test-retest reliability of memory task functional magnetic resonance imaging in Alzheimer disease clinical trials
64/100 ✓ Peer-reviewed Treatments Archives of neurology
Key finding: Encoding-task fMRI was successfully implemented in a single-site, 24-week, AD randomized controlled trial. +1 more finding
Full summary, score breakdown and related studies → Original source
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