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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 10,126–10,150 of 27,380 studies, newest first · page 406 of 1096.

June 2021 25

  1. 2021-06-07

    Metformin, Macrophage Dysfunction and Atherosclerosis

    ✓ Peer-reviewed Drug development Frontiers in immunology

    Key finding: More and more evidence shows that metformin can regulate the function of macrophages in atherosclerosis, including reducing the differentiation of monocytes and inhibiting the inflammation, oxidative stress, polarization, foam cell formation and apoptosis of macrophages. +4 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2021-06-07

    Molecular mechanisms of cell death in neurological diseases

    ✓ Peer-reviewed Disease mechanisms Cell death and differentiation

    Key finding: Abnormalities in PCD signalling cascades, such as apoptosis, necroptosis, pyroptosis, ferroptosis, and cell death associated with autophagy as well as in unprogrammed necrosis can be observed in the pathogenesis of various neurological diseases.

    Full summary, score breakdown and related studies → Original source

  3. 2021-06-07

    Common variants in Alzheimer's disease and risk stratification by polygenic risk scores

    ✓ Peer-reviewed Genetics Nature communications

    Key finding: We first perform a large genetic association study by merging all available case-control datasets and by-proxy study results (discovery n = 409,435 and validation size n = 58,190). +1 more finding

    Full summary, score breakdown and related studies → Original source

  4. 2021-06-07

    Phospholipids of APOE lipoproteins activate microglia in an isoform-specific manner in preclinical models of Alzheimer's disease

    ✓ Peer-reviewed TREM2 and immune genetics Nature communications

    Key finding: Here we report an APOE isoform-specific phospholipid signature with correlation between human APOEε3/3 and APOEε4/4 AD brain and lipoproteins from astrocyte conditioned media of APOE3 and APOE4 mice. +3 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2021-06-07

    Brain mechanisms underlying neuropsychiatric symptoms in Alzheimer's disease: a systematic review of symptom-general and -specific lesion patterns

    ✓ Peer-reviewed Mild cognitive impairment Molecular neurodegeneration

    Key finding: Neuropsychiatric symptoms (NPSs) are common in patients with Alzheimer's disease (AD) and are associated with accelerated cognitive impairment and earlier deaths. +1 more finding

    Full summary, score breakdown and related studies → Original source

  6. 2021-06-07

    A multicentre validation study of the diagnostic value of plasma neurofilament light

    ✓ Peer-reviewed Lewy body dementia Nature communications

    Key finding: Plasma NfL was significantly increased in all cortical neurodegenerative disorders, amyotrophic lateral sclerosis and atypical parkinsonian disorders.

    Full summary, score breakdown and related studies → Original source

  7. 2021-06-07

    FDA Grants Accelerated Approval for ADUHELM (aducanumab) as the First and Only Alzheimer's Disease Treatment to Address a Defining Pathology of the Disease

    ⚠ Regulatory decision — not a study Treatments U.S. Food and Drug Administration (announced via Biogen press release)

    Key finding: Approved under the accelerated pathway based on amyloid plaque reduction (71% in the EMERGE trial, 59% in ENGAGE, both p<0.0001) as a surrogate marker, not confirmed clinical benefit +2 more findings

    Scored 17 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  8. 2021-06-05

    Shared Genetic Etiology between Alzheimer's Disease and Blood Levels of Specific Cytokines and Growth Factors

    ✓ Peer-reviewed Genetics Genes

    Key finding: Late-onset Alzheimer's disease (AD) has a significant genetic and immunological component, but the molecular mechanisms through which genetic and immunity-related risk factors and their interplay contribute to AD pathogenesis are unclear. +2 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2021-06-05

    "Don't Phos Over Tau": recent developments in clinical biomarkers and therapies targeting tau phosphorylation in Alzheimer's disease and other tauopathies

    ✓ Peer-reviewed Drug development Molecular neurodegeneration

    Key finding: In tauopathies like AD, increased phosphorylation or hyperphosphorylation can contribute to microtubule dysfunction and is associated with tau aggregation. +2 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2021-06-04

    Donanemab leads to less decline in early Alzheimer's disease

    ✓ Peer-reviewed Treatments The Brown University Psychopharmacology Update

    Key finding: Patients with early symptomatic Alzheimer's disease showed less cognitive and functional decline with donanemab compared with placebo in a Phase 2 study offering up to 72 weeks of treatment. +2 more findings

    Full summary, score breakdown and related studies → Original source

  11. 2021-06-04

    Elevated soluble amyloid beta protofibrils in Down syndrome and Alzheimer's disease

    ✓ Peer-reviewed Clinical trials Molecular and cellular neurosciences

    Key finding: Elevated levels of soluble Aβ protofibrils and insoluble Aβx-40 and Aβx-42 in formic acid brain extracts, and elevated immunohistochemical staining of Aβ deposits were demonstrated with the antibody BAN2401 (lecanemab) in DS and AD compared with NDC. +1 more finding

    Full summary, score breakdown and related studies → Original source

  12. 2021-06-04

    Vertical saccadic palsy and foveal retinal thinning in Niemann-Pick disease type C

    ✓ Peer-reviewed Brain scans and imaging PloS one

    Key finding: Saccadometry revealed slowed peak velocity compared to controls most evident vertically. +4 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2021-06-04

    Screening for intrinsic capacity impairments as markers of increased risk of frailty and disability in the context of integrated care for older people: Secondary analysis of MAPT

    ✓ Peer-reviewed Risk factors Maturitas

    Key finding: Screening for IC impairments identifies older adults at higher risk of incident frailty and incident IADL/ADL disability. +2 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2021-06-04

    Cross-cohort generalizability of deep and conventional machine learning for MRI-based diagnosis and prediction of Alzheimer's disease

    ✓ Peer-reviewed Digital health tools NeuroImage. Clinical

    Key finding: Application to conversion prediction in MCI yielded significantly higher performance for SVM (AUC = 0.756; 95%CI: 0.720-0.788) than for CNN (AUC = 0.742; 95%CI: 0.709-0.776) (p<0.01 for McNemar's test). +1 more finding

    Full summary, score breakdown and related studies → Original source

  15. 2021-06-04

    Correlating natural language processing and automated speech analysis with clinician assessment to quantify speech-language changes in mild cognitive impairment and Alzheimer's dementia

    ✓ Peer-reviewed Digital health tools Alzheimer's research & therapy

    Key finding: Our results suggest that correlating NLP and ASA with clinician observations is an objective and novel approach to measuring speech and language changes in neurodegenerative disorders. +1 more finding

    Full summary, score breakdown and related studies → Original source

  16. 2021-06-03

    Acute systemic inflammation exacerbates neuroinflammation in Alzheimer's disease: IL-1β drives amplified responses in primed astrocytes and neuronal network dysfunction

    ✓ Peer-reviewed Inflammation and the immune system Alzheimer's & dementia : the journal of the Alzheimer's Association

    Key finding: Astrocytes were primed to produce exaggerated chemokine responses to intrahippocampal IL-1β. +4 more findings

    Full summary, score breakdown and related studies → Original source

  17. 2021-06-03

    A map of transcriptional heterogeneity and regulatory variation in human microglia

    ✓ Peer-reviewed Genetics Nature genetics

    Key finding: We follow up one of our findings using a human induced pluripotent stem cell-based macrophage model to fine-map a candidate causal variant for Alzheimer's disease at the BIN1 locus.

    Full summary, score breakdown and related studies → Original source

  18. 2021-06-03

    Fifteen Years of the Australian Imaging, Biomarkers and Lifestyle (AIBL) Study: Progress and Observations from 2,359 Older Adults Spanning the Spectrum from Cognitive Normality to Alzheimer's Disease

    ✓ Peer-reviewed Mild cognitive impairment Journal of Alzheimer's disease reports

    Key finding: This fifteen-year study provides a large database of highly characterized individuals with longitudinal cognitive, imaging and lifestyle data and biofluid collections, to aid in the development of interventions to delay onset, prevent or treat AD.

    Full summary, score breakdown and related studies → Original source

  19. 2021-06-02

    Cerebrospinal Fluid Alzheimer's Biomarkers and Neurofilament Light Profile of Idiopathic Normal Pressure Hydrocephalus in China: A PUMCH Cohort Study

    ✓ Peer-reviewed Tau biomarkers Neuro-degenerative diseases

    Key finding: Twenty-seven iNPH, 27 AD, and 18 controls were included. +4 more findings

    Full summary, score breakdown and related studies → Original source

  20. 2021-06-02

    Effects of pre-analytical procedures on blood biomarkers for Alzheimer's pathophysiology, glial activation, and neurodegeneration

    ✓ Peer-reviewed Biomarkers Alzheimer's & dementia (Amsterdam, Netherlands)

    Key finding: The same tube type should be used in research studies on blood biomarkers. +1 more finding

    Full summary, score breakdown and related studies → Original source

  21. 2021-06-02

    Adverse Health Effects of Frailty: Systematic Review and Meta-Analysis of Middle-Aged and Older Adults With Implications for Evidence-Based Practice

    ✓ Peer-reviewed Clinical safety Worldviews on evidence-based nursing

    Key finding: We collected a total of 29 prospective studies for the systematic literature review and meta-analysis. +4 more findings

    Full summary, score breakdown and related studies → Original source

  22. 2021-06-02

    Traumatic Brain Injury and Risk of Neurodegenerative Disorder

    ✓ Peer-reviewed Risk factors Biological psychiatry

    Key finding: The heterogeneous clinical and neuropathological outcomes associated with TBI are likely reflective of the multifaceted postinjury acute and chronic processes that may contribute to neurodegeneration.

    Full summary, score breakdown and related studies → Original source

  23. 2021-06-01

    Meta-ethnography of the purpose of meaningful occupation for people living with dementia

    ✓ Peer-reviewed Health systems and care delivery International journal of older people nursing

    Key finding: We found the fundamental purpose of occupation is to support the person living with dementia to feel they are living a meaningful and fulfilling life. +3 more findings

    Full summary, score breakdown and related studies → Original source

  24. 2021-06-01

    [Cognitive reserve, one of the determinants of the progression of Alzheimer's disease]

    ✓ Peer-reviewed Risk factors Geriatrie et psychologie neuropsychiatrie du vieillissement

    Key finding: To appraise the validity of the Yaakov Stern's theory, which postulates that the first cognitive deficits of Alzheimer's disease are delayed in patients with high cognitive reserve, compared to those with low cognitive reserve, but is subsequently associated with faster cognitive decline when cerebral lesions have reached some degree of severity. +2 more findings

    Full summary, score breakdown and related studies → Original source

  25. 2021-06 month only

    Sleep, Aging, and Daily Functioning

    ✓ Peer-reviewed Risk factors The Nursing clinics of North America

    Key finding: Older adults who do not sleep well frequently have difficulty sustaining attention, display slower physical response times, and have memory issues that may contribute to depression or early dementia. +3 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →