Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 25,126–25,150 of 27,380 studies, newest first · page 1006 of 1096.
July 2001 18
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2001-07-01
Accuracy of administrative data to assess comorbidity in patients with heart disease. an Australian perspective
40/100 ✓ Peer-reviewed Digital health tools Journal of clinical epidemiology
Key finding: These were compared with the 10 discharge codes obtained from the hospital administrative records (referred to as the "administrative data").
Full summary, score breakdown and related studies → Original source
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2001-07-01
Imaging of onset and progression of Alzheimer's disease with voxel-compression mapping of serial magnetic resonance images
48/100 ✓ Peer-reviewed Getting a diagnosis Lancet (London, England)
Key finding: Progressive atrophy was revealed in presymptomatic individuals, with posterior cingulate and neocortical temporoparietal cortical losses, and medial temporal-lobe atrophy.
Full summary, score breakdown and related studies → Original source
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2001-07-01
Informal costs of dementia care: estimates from the National Longitudinal Caregiver Study
62/100 ✓ Peer-reviewed Costs and economics The journals of gerontology. Series B, Psychological sciences and social sciences
Key finding: This study provides a comprehensive estimate of the excess costs that result from providing informal dementia care in the community. +2 more findings
Full summary, score breakdown and related studies → Original source
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2001-07-01
Healthy centenarians do not exist, but autonomous centenarians do: a population-based study of morbidity among Danish centenarians
45/100 ✓ Peer-reviewed Biomarkers Journal of the American Geriatrics Society
Key finding: Because they have a high prevalence of several common diseases and chronic conditions, Danish centenarians are not healthy.
Full summary, score breakdown and related studies → Original source
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2001-07-01
The ABILHAND questionnaire as a measure of manual ability in chronic stroke patients: Rasch-based validation and relationship to upper limb impairment
36/100 ✓ Peer-reviewed Vascular contributions Stroke
Key finding: The ABILHAND questionnaire results in a valid person-centered measure of manual ability in everyday activities. +4 more findings
Full summary, score breakdown and related studies → Original source
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2001-07-01
Effects of age on tissues and regions of the cerebrum and cerebellum
36/100 ✓ Peer-reviewed Hippocampus size on brain scans Neurobiology of aging
Key finding: The results were: 1) Age-related losses in the hippocampus were significantly accelerated relative to gray matter losses elsewhere in the brain. 2) Among the cerebral lobes, the frontal lobes were disproportionately affected by cortical volume loss and increased white matter abnormality. 3) Loss of cerebral and cerebellar white matter occurred later than, but was ultimately greater than, loss of gray matter. +2 more findings
Full summary, score breakdown and related studies → Original source
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2001-07-01
The effects of driving cessation on the elderly with dementia and their caregivers
36/100 ✓ Peer-reviewed Clinical safety Accident; analysis and prevention
Key finding: Overall, these findings reinforce the importance of both developing transportation policies to support the functioning of informal transportation structures and in improving the range of alternative transportation options for those individuals with particular disabilities--like dementia--who are not well served by either informal arrangements or by formal transportation services for the disabled.
Full summary, score breakdown and related studies → Original source
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2001-07-01
Active glycation in neurofibrillary pathology of Alzheimer disease: N(epsilon)-(carboxymethyl) lysine and hexitol-lysine
36/100 ✓ Peer-reviewed Disease mechanisms Free radical biology & medicine
Key finding: Because advanced glycation end products are accelerated by, and result in formation of, oxygen-derived free radicals, they represent an important component of the oxidative stress hypothesis of Alzheimer disease (AD). +3 more findings
Full summary, score breakdown and related studies → Original source
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2001-07-01
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2001-07-01
Chemokines and their receptors in the central nervous system
43/100 ✓ Peer-reviewed Inflammation and the immune system Frontiers in neuroendocrinology
Key finding: They are classified into four classes based on the positions of key cystiene residues: C, CC, CXC, and CX3C. +3 more findings
Full summary, score breakdown and related studies → Original source
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2001-07-01
Incidence of dementia: does gender make a difference?
61/100 ✓ Peer-reviewed Long-term cohort studies Neurobiology of aging
Key finding: However, that was based on rather limited data. +3 more findings
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2001-07-01
Vesicle permeabilization by protofibrillar alpha-synuclein: implications for the pathogenesis and treatment of Parkinson's disease
50/100 ✓ Peer-reviewed Lewy body dementia Biochemistry
Key finding: Both alpha-synuclein mutations linked to autosomal dominant early-onset forms of PD promote the in vitro conversion of the natively unfolded protein into ordered prefibrillar oligomers, suggesting that these protofibrils, rather than the fibril itself, may induce cell death.
Full summary, score breakdown and related studies → Original source
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2001-07-01
Association of REM sleep behavior disorder and neurodegenerative disease may reflect an underlying synucleinopathy
51/100 ✓ Peer-reviewed Risk factors Movement disorders : official journal of the Movement Disorder Society
Key finding: Our objective was to examine whether rapid eye movement (REM) sleep behavior disorder occurs in disproportionally greater frequency in multiple system atrophy (MSA), Parkinson's disease (PD), and dementia with Lewy bodies (DLB), collectively known as the synucleinopathies, compared to other nonsynucleinopathy neurodegenerative disorders. +4 more findings
Full summary, score breakdown and related studies → Original source
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2001-07-01
Comprehension of metaphors and idioms in patients with Alzheimer's disease: a longitudinal study
45/100 ✓ Peer-reviewed Digital health tools Brain : a journal of neurology
Key finding: The results showed that the decline of figurative language is not an early symptom of dementia and can occur independently from the impairment of propositional language.
Full summary, score breakdown and related studies → Original source
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2001-07-01
Hippocampal formation glucose metabolism and volume losses in MCI and AD
59/100 ✓ Peer-reviewed Brain scans and imaging Neurobiology of aging
Key finding: The results supported the hypotheses: 1) entorhinal cortex MRglu and hippocampal volume were most accurate in classifying NL and MCI; 2) both imaging modalities identified the temporal neocortex as best separating MCI and AD, whereas widespread changes accurately classified NL and AD; 3) In most between group comparisons regional MRglu measures were diagnostically superior to volume measures. +1 more finding
Full summary, score breakdown and related studies → Original source
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2001-07-01
Early detection and differential diagnosis of Alzheimer's disease and depression with neuropsychological tasks
50/100 ✓ Peer-reviewed Getting a diagnosis Dementia and geriatric cognitive disorders
Key finding: A visuo-spatial associative learning test accurately distinguished AD from depressed/control subjects and revealed an apparent sub-group of QD patients who performed like AD patients.
Full summary, score breakdown and related studies → Original source
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2001-07-01
Differing patterns of temporal atrophy in Alzheimer's disease and semantic dementia
57/100 ✓ Peer-reviewed Getting a diagnosis Neurology
Key finding: Hippocampal atrophy is not specific for AD but is also seen in semantic dementia. +1 more finding
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2001-07-01
Treatment of protein-energy malnutrition in chronic nonmalignant disorders
58/100 ✓ Peer-reviewed Prevention and risk The American journal of clinical nutrition
Key finding: Protein-energy malnutrition (PEM) is common in connection with chronic disease and is associated with increased morbidity and mortality. +2 more findings
Full summary, score breakdown and related studies → Original source
June 2001 7
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2001-06-26
Midlife vascular risk factors and late-life mild cognitive impairment: A population-based study
48/100 ✓ Peer-reviewed Mild cognitive impairment Neurology
Data point to a role for midlife vascular risk factors in the development of MCI in late life.
Full summary, score breakdown and related studies → Original source
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2001-06-16
Midlife vascular risk factors and Alzheimer's disease in later life: longitudinal, population based study
63/100 ✓ Peer-reviewed Vascular contributions BMJ
Key finding: People with raised systolic blood pressure (≥160 mm Hg) or high serum cholesterol concentration (≥6.5 mmol/l) in midlife had a significantly higher risk of Alzheimer's disease in later life, even after adjustment for age, body mass index, education, vascular events, smoking status, and alcohol consumption, than those with normal systolic blood pressure (odds ratio 2.3, 95% confidence interval 1.0 to 5.5) or serum cholesterol (odds ratio 2.1, 1.0 to 4.4). +4 more findings
Full summary, score breakdown and related studies → Original source
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2001-06-01
Increased lipid peroxidation precedes amyloid plaque formation in an animal model of Alzheimer amyloidosis
36/100 ✓ Peer-reviewed Disease mechanisms The Journal of neuroscience : the official journal of the Society for Neuroscience
Key finding: To determine whether amyloid beta (Abeta) deposition in vivo is associated with increased LPO, we examined iP levels in a transgenic mouse model (Tg2576) of AD amyloidosis. +1 more finding
Full summary, score breakdown and related studies → Original source
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2001-06-01
Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: In vitro and in vivo mechanisms related to Alzheimer's disease
36/100 ✓ Peer-reviewed Disease mechanisms The Journal of neuroscience : the official journal of the Society for Neuroscience
Key finding: These findings support the model that derangement of hippocampus signal transduction cascades in AD arises as a consequence of increased Abeta burden and chronic activation of the ERK MAPK cascade in an alpha7 nAChR-dependent manner that eventually leads to the downregulation of ERK2 MAPK and decreased phosphorylation of CREB protein.
Full summary, score breakdown and related studies → Original source
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2001-06-01
Autoantibodies to amyloid-beta and Alzheimer's disease
64/100 ✓ Peer-reviewed Treatments Annals of neurology
Key finding: These data suggest that low levels of anti-amyloid-beta autoantibodies are frequent in the elderly population but do not confer protection against developing dementia.
Full summary, score breakdown and related studies → Original source
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2001-06-01
Local cellular sources of apolipoprotein E in the human retina and retinal pigmented epithelium: implications for the process of drusen formation
36/100 ✓ Peer-reviewed Brain scans and imaging American journal of ophthalmology
Key finding: Apolipoprotein E protein is strategically located at the same anatomic locus where drusen are situated, and the retinal pigmented epithelium is the most likely local biosynthetic source of apolipoprotein E at that location. +2 more findings
Full summary, score breakdown and related studies → Original source
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2001-06-01
Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice
40/100 ✓ Peer-reviewed Biomarkers Neuron
Key finding: General health and body weight parameters were significantly more stable in the treated animals. +1 more finding
Full summary, score breakdown and related studies → Original source
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