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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 22,876–22,900 of 27,380 studies, newest first · page 916 of 1096.

November 2006 25

  1. 2006-11-16

    Donepezil markedly potentiates memantine neurotoxicity in the adult rat brain

    ✓ Peer-reviewed Treatments Neurobiology of aging

    Key finding: These findings raise questions about using this drug combination in AD, especially in the absence of evidence that the combination is beneficial, or that either drug arrests or reverses the disease process.

    Full summary, score breakdown and related studies → Original source

  2. 2006-11-14

    Improving Caregiver Well-Being Delays Nursing Home Placement of Patients With Alzheimer Disease

    ✓ Peer-reviewed Caregiving Neurology

    Key finding: Spouses of caregivers who received the intervention had a 28.3% lower rate of nursing home placement than usual-care controls (hazard ratio 0.717, p=0.025) +2 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2006-11-13

    MRI of hippocampus and entorhinal cortex in mild cognitive impairment: a follow-up study

    ✓ Peer-reviewed Mild cognitive impairment Neurobiology of aging

    Key finding: The Mini-Mental State Examination (MMSE) score at baseline, WML load, or APOE genotype were not significant predictors of progression.

    Full summary, score breakdown and related studies → Original source

  4. 2006-11-13

    A fully automated method for quantifying and localizing white matter hyperintensities on MR images

    ✓ Peer-reviewed Caregiving Psychiatry research

    Key finding: White matter hyperintensities (WMH), commonly found on T2-weighted FLAIR brain MR images in the elderly, are associated with a number of neuropsychiatric disorders, including vascular dementia, Alzheimer's disease, and late-life depression. +4 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2006-11-10

    Cerebrospinal fluid beta-amyloid 1-42 concentration may predict cognitive decline in older women

    ✓ Peer-reviewed Cognitive tests and assessment Journal of neurology, neurosurgery, and psychiatry

    Key finding: Low levels of cerebrospinal fluid (CSF) beta-amyloid 1-42 (Abeta42) and high total tau (T-tau) are diagnostic for manifest Alzheimer's disease. +3 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2006-11-09

    The microglial NADPH oxidase complex as a source of oxidative stress in Alzheimer's disease

    ✓ Peer-reviewed Inflammation and the immune system Journal of neuroinflammation

    Key finding: The principal neuropathological hallmarks of Alzheimer's disease are the senile plaques and the neurofibrillary tangles. +3 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2006-11-09

    CSF markers in Alzheimer disease patients are not related to the different degree of cognitive impairment

    ✓ Peer-reviewed Tau biomarkers Journal of the neurological sciences

    Key finding: Yet, their sensitivity to assess the different degree of cognitive deficit is not fully clarified. +3 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2006-11-09

    Endogenous sex hormone levels and risk of cognitive decline in an older biracial cohort

    ✓ Peer-reviewed Disparities Neurobiology of aging

    Key finding: Older women with low estradiol levels were more likely to experience decline in global cognitive function and verbal memory, and a similar trend was observed for verbal memory in men. +3 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2006-11-08

    Modulation of gene expression and cytoskeletal dynamics by the amyloid precursor protein intracellular domain (AICD)

    ✓ Peer-reviewed Risk genes beyond APOE Molecular biology of the cell

    Key finding: Recently, it has been demonstrated that AICD has transactivation potential; however, the targets of AICD-dependent gene regulation and hence the physiological role of AICD remain largely unknown. +3 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2006-11-07

    Twenty years of research on cytokine-induced sickness behavior

    ✓ Peer-reviewed Risk factors Brain, behavior, and immunity

    Key finding: It was subsequently shown that physiological concentrations of proinflammatory cytokines that occur after infection act in the brain to induce common symptoms of sickness, such as loss of appetite, sleepiness, withdrawal from normal social activities, fever, aching joints and fatigue. +1 more finding

    Full summary, score breakdown and related studies → Original source

  11. 2006-11-07

    Neurofibrillary tangle-predominant dementia: comparison with classical Alzheimer disease

    ✓ Peer-reviewed Genetics Acta neuropathologica

    Key finding: Neuropathology reveals abundant allocortical neurofibrillary pathology with no or few isocortical tau lesions, absence of neuritic plaques, absence or scarcity of amyloid deposits, but neurofibrillary changes comprising both 3 and 4 repeat (3R and 4R) tau immunohistochemistry are not significantly different from those in classical AD.

    Full summary, score breakdown and related studies → Original source

  12. 2006-11-03

    Calcium-mediated transient phosphorylation of tau and amyloid precursor protein followed by intraneuronal amyloid-beta accumulation

    ✓ Peer-reviewed Risk genes beyond APOE The Journal of biological chemistry

    Key finding: A common cellular mechanism leading to the production of these potent toxins remains elusive. +3 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2006-11-02

    A Phase II study targeting amyloid-beta with 3APS in mild-to-moderate Alzheimer disease

    ✓ Peer-reviewed Tau biomarkers Neurology

    Key finding: As a potential disease-modifying treatment for Alzheimer disease (AD), 3-amino-1-propanesulfonic acid (3APS) is a compound that binds to amyloid beta (Abeta), a toxic protein known to aggregate, leading to amyloid plaque deposition in the brain. +3 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2006-11-01

    Cockayne syndrome in adults: review with clinical and pathologic study of a new case

    ✓ Peer-reviewed Risk factors Journal of child neurology

    Key finding: They result in premature death, usually in childhood, exceptionally in adults.

    Full summary, score breakdown and related studies → Original source

  15. 2006-11-01

    A convergent model for cognitive dysfunctions in Parkinson's disease: the critical dopamine-acetylcholine synaptic balance

    ✓ Peer-reviewed Treatments The Lancet. Neurology

    Key finding: There is now an increasing interest in the cognitive and non-motor symptoms of Parkinson's disease and in cholinesterase-inhibitor therapy for dementia associated with Parkinson's disease. +1 more finding

    Full summary, score breakdown and related studies → Original source

  16. 2006-11-01

    Transport pathways for clearance of human Alzheimer's amyloid beta-peptide and apolipoproteins E and J in the mouse central nervous system

    ✓ Peer-reviewed Genetics Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

    Key finding: We show (i) Abeta40 is cleared rapidly across the BBB via low-density lipoprotein receptor-related protein (LRP)1 at a rate of 0.21 pmol/min g ISF or 6-fold faster than via the ISF flow; (ii) Abeta42 is removed across the BBB at a rate 1.9-fold slower compared with Abeta40; (iii) apoE, lipid-poor isoform 3, is cleared slowly via the ISF flow and across the BBB (0.03-0.04 pmol/min g ISF), and after lipidation its transport at the BBB becomes barely detectable within 30 mins; (iv) apoJ is eliminated rapidly across the BBB (0.16 pmol/min g ISF) via LRP2.

    Full summary, score breakdown and related studies → Original source

  17. 2006-11-01

    Diabetes mellitus and dementia

    ✓ Peer-reviewed Vascular contributions Diabetes & metabolism

    Key finding: The increased risk of AD may also be mediated by the exacerbation of B-amyloid neurotoxicity by advanced glycosylation end products identified in the matrix of neurofibrillary tangles and amyloid plaques in AD brains, or associations with insulin functions. +1 more finding

    Full summary, score breakdown and related studies → Original source

  18. 2006-11-01

    Diabetes mellitus and risk of developing Alzheimer disease: results from the Framingham Study

    ✓ Peer-reviewed Vascular contributions Archives of neurology

    Key finding: Diabetes mellitus did not increase the risk of incident AD in the Framingham cohort overall; however, DM may be a risk factor for AD in the absence of other known major AD risk factors. +2 more findings

    Full summary, score breakdown and related studies → Original source

  19. 2006-11-01

    Hippocampus volume loss due to chronic heavy drinking

    ✓ Peer-reviewed Hippocampus size on brain scans Alcoholism, clinical and experimental research

    Key finding: These data support the view that heavy drinking exerts a unique and selectively injurious effect on the hippocampus. +2 more findings

    Full summary, score breakdown and related studies → Original source

  20. 2006-11-01

    Clinical practice with anti-dementia drugs: a consensus statement from British Association for Psychopharmacology

    ✓ Peer-reviewed Prevention trials Journal of psychopharmacology (Oxford, England)

    Key finding: There is type 1b evidence for gingko biloba in producing a modest benefit of cognitive function; cholinesterase inhibitors for the treatment of people with Lewy body disease (particularly neuropsychiatric symptoms); cholinesterase inhibitors and memantine in treatment cognitive impairment associated with vascular dementia; and the effect of metal collating agents (although these should not be prescribed until more data on safety and efficacy are available).

    Full summary, score breakdown and related studies → Original source

  21. 2006-11-01

    Protein oxidation and lipid peroxidation in brain of subjects with Alzheimer's disease: insights into mechanism of neurodegeneration from redox proteomics

    ✓ Peer-reviewed Disease mechanisms Antioxidants & redox signaling

    Key finding: Alzheimer's disease (AD), the leading cause of dementia, involves regionalized neuronal death, synaptic loss, and an accumulation of intraneuronal, neurofibrillary tangles and extracellular senile plaques. +4 more findings

    Full summary, score breakdown and related studies → Original source

  22. 2006-11-01

    Overdependence on degraded gist memory in Alzheimer's disease.

    ✓ Peer-reviewed Cognitive tests and assessment Neuropsychology

    Key finding: Gist processes were manipulated by blocking or mixing studied words according to their associations and by varying the associative strength between studied and nonstudied words at test. +4 more findings

    Full summary, score breakdown and related studies → Original source

  23. 2006-11-01

    Upregulated expression of purinergic P2X(7) receptor in Alzheimer disease and amyloid-beta peptide-treated microglia and in peptide-injected rat hippocampus

    ✓ Peer-reviewed Inflammation and the immune system Journal of neuropathology and experimental neurology

    Key finding: Semiquantitative reverse transcriptase-polymerase chain reaction showed enhanced expression (increase of 70%) of P2X(7)R in AD microglia compared with ND cells (analysis of 6 AD and 8 ND cases). +3 more findings

    Full summary, score breakdown and related studies → Original source

  24. 2006-11-01

    Abeta species removal after abeta42 immunization

    ✓ Peer-reviewed Brain tissue and pathology Journal of neuropathology and experimental neurology

    Key finding: At 1 to 2 years after immunization, 2 cases showed extensive areas cleared of plaques (69% and 86% of the temporal cortex was plaque-free). +3 more findings

    Full summary, score breakdown and related studies → Original source

  25. 2006-11-01

    The NUCOG: validity and reliability of a brief cognitive screening tool in neuropsychiatric patients

    ✓ Peer-reviewed Cognitive tests and assessment The Australian and New Zealand journal of psychiatry

    Key finding: The NUCOG was undertaken with the MMSE on a total of 347 individuals, with 82 subjects in the control group and 265 in the patient group. +3 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →