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63/100

✓ Peer-reviewed alzhub usefulness score 63 out of 100. Mild cognitive impairment

Topic: Brain proteins, microglia and lab models

The vitamin E and donepezil trial for the treatment of amnestic mild cognitive impairment (MCI) was conducted at 69 centers in North America; 24 centers participated in an MRI sub study. The objective of this study was to evaluate the effect of treatment on MRI atrophy rates; and validate rate measures from serial MRI as indicators of disease progression in multi center therapeutic trials for MCI. Annual percent change (APC) from baseline to follow-up was measured for hippocampus, entorhinal cortex, whole brain, and ventricle in the 131 subjects who remained in the treatment study and completed technically satisfactory baseline and follow-up scans. Although a non-significant trend toward slowing of hippocampal atrophy rates was seen in APOE is an element of 4 carriers treated with donepezil; no treatment effect was confirmed for any MRI measure in either treatment group. For each of the four brain atrophy rate measures, APCs were greater in subjects who converted to AD than non-converters, and were greater in APOE is an element of 4 carriers than non-carriers. MRI APCs and changes in cognitive test performance were uniformly correlated in the expected direction (all p<0.000). Results of this study support the feasibility of using MRI as an outcome measure of disease progression in multi center therapeutic trials for MCI.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Jack, C. R., Petersen, R. C., Grundman, M., Jin, S., Gamst, A., Ward, C. P., et al. (2008). Longitudinal MRI findings from the vitamin E and donepezil treatment study for MCI. Neurobiology of aging. https://doi.org/10.1016/j.neurobiolaging.2007.03.004

Vancouver

Jack CR, Petersen RC, Grundman M, Jin S, Gamst A, Ward CP, et al. Longitudinal MRI findings from the vitamin E and donepezil treatment study for MCI. Neurobiology of aging. 2008. doi:10.1016/j.neurobiolaging.2007.03.004. PMID: 17452062.

BibTeX

@article{jack2008-17452062,
  author  = {Jack, C. R. and Petersen, R. C. and Grundman, M. and Jin, S. and Gamst, A. and Ward, C. P. and Sencakova, D. and Doody, R. S. and others},
  title   = {{Longitudinal MRI findings from the vitamin E and donepezil treatment study for MCI}},
  journal = {Neurobiology of aging},
  year    = {2008},
  doi     = {10.1016/j.neurobiolaging.2007.03.004},
  pmid    = {17452062},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2007.03.004}
}

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Key findings

Although a non-significant trend toward slowing of hippocampal atrophy rates was seen in APOE is an element of 4 carriers treated with donepezil; no treatment effect was confirmed for any MRI measure in either treatment group.
Results of this study support the feasibility of using MRI as an outcome measure of disease progression in multi center therapeutic trials for MCI.

Why it matters

In this MRI substudy of a vitamin E and donepezil trial, no treatment effect on brain atrophy rates was confirmed for either treatment group. The results support using MRI as a measure of disease progression in trials, not as a treatment.

Study details

Participants131
Evidence strengthLow

How this study scored 63/100

Published in a peer-reviewed journal, and it is a randomized controlled trial. Scored zero for effect reported because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Neurobiology of aging)
Journal's citation record	3 / 4	Neurobiology of Aging: journal h-index 263 (OpenAlex, 2026-10-29)
Study design	11 / 12	A randomized controlled trial (from PubMed type “Randomized Controlled Trial”)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	1 / 5	2008 — within 20 year(s) of the newest study here
Sample size	2 / 4	131 participants
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomized / blinded	1 / 2	Randomized (as stated in the record)
Times cited	5 / 7	Cited 143 times (OpenAlex, 2026-10-10)
Citations per year	2 / 5	7.2 citations a year over 20 year(s) since 2008
Impact for its field and year	4 / 6	Cited 8.2× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	3 / 6	Cited by 14 other studies in this library
Still being cited	1 / 4	Cited 4 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	3 / 4	Last-listed author Leon J. Thal: h-index 90 (OpenAlex, whole career)
Institution's track record	2 / 3	University of California San Diego: institution h-index 1,852 (OpenAlex)
Multicenter collaboration	2 / 3	PubMed indexes it as a multicentre study
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 17452062)
Free to read	0 / 2	Behind a paywall — scores zero
Total	63 / 100	—

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