Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 22,426–22,450 of 27,380 studies, newest first · page 898 of 1096.
September 2007 25
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2007-09-28
DYRK1A-mediated hyperphosphorylation of Tau. A functional link between Down syndrome and Alzheimer disease
46/100 ✓ Peer-reviewed Down syndrome and Alzheimer's The Journal of biological chemistry
Key finding: A significant increase in the amount of pT212 was found in the brains of DYRK1A transgenic mice when compared with age-matched littermate controls. +3 more findings
Full summary, score breakdown and related studies → Original source
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2007-09-26
Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers
40/100 ✓ Peer-reviewed Risk factors Molecular neurodegeneration
Key finding: Since the fibril specific antibodies are conformation dependent, sequence-independent, and recognize epitopes that are distinct from those present in prefibrillar oligomers, they may have broad utility for detecting and characterizing the accumulation of amyloid fibrils and fibrillar type oligomers in degenerative diseases. +2 more findings
Full summary, score breakdown and related studies → Original source
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2007-09-26
MRI patterns of atrophy associated with progression to AD in amnestic mild cognitive impairment
51/100 ✓ Peer-reviewed Brain scans and imaging Neurology
Key finding: The regions of loss observed in subjects with amnestic mild cognitive impairment (aMCI) who progressed to Alzheimer disease (AD) within 18 months of the MRI are typical of subjects with AD. +2 more findings
Full summary, score breakdown and related studies → Original source
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2007-09-25
Repeated social defeat-induced depression-like behavioral and biological alterations in rats: involvement of cholecystokinin
40/100 ✓ Peer-reviewed Hippocampus size on brain scans Molecular psychiatry
Key finding: Repeated social defeat triggers changes that could be considered as behavioral and biological correlates of depressive symptoms in humans, such as a hyperactivity of hypothalamic-pituitary-adrenal (HPA) axis (increase of serum corticosterone levels and of adrenal gland weight), increased immobility time in the forced swimming test (FST), decrease of body weight and of sweet water consumption and reduction of hippocampal volume associated with a decreased cell proliferation in the dentate gyrus. +3 more findings
Full summary, score breakdown and related studies → Original source
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2007-09-24
Prediction and longitudinal study of CSF biomarkers in mild cognitive impairment
58/100 ✓ Peer-reviewed Mild cognitive impairment Neurobiology of aging
Key finding: At baseline and at follow-up MCI-AD showed higher levels P-tau(231), T-tau, IP, P-tau(231)/Abeta(42/40) and T-tau/Abeta(42/40) ratios and lower Abeta(42)/Abeta(40) than MCI-MCI or NL-NL. +1 more finding
Full summary, score breakdown and related studies → Original source
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2007-09-19
DNA methylation in the human cerebral cortex is dynamically regulated throughout the life span and involves differentiated neurons
52/100 ✓ Peer-reviewed Genetics PloS one
Key finding: Additionally, methylation studies on sorted nuclei provided evidence for bidirectional methylation events in cortical neurons during the transition from childhood to advanced age, as reflected by significant increases at 3, and a decrease at 1 of 10 loci.
Full summary, score breakdown and related studies → Original source
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2007-09-19
Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study
52/100 ✓ Peer-reviewed Vascular contributions BMC medical genetics
Key finding: Our results suggest that genes associated with clinical neurological disease also have detectable effects on subclinical phenotypes. +4 more findings
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2007-09-18
Some phytochemical, pharmacological and toxicological properties of ginger (Zingiber officinale Roscoe): a review of recent research
48/100 ✓ Peer-reviewed Risk factors Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Key finding: This article aims at reviewing the most salient recent reports on these investigations. +4 more findings
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2007-09-18
Deficits of knowledge versus executive control in semantic cognition: insights from cued naming
44/100 ✓ Peer-reviewed Digital health tools Neuropsychologia
Key finding: The stroke aphasic patients with multimodal semantic deficits cued very readily and demonstrated near-perfect name retrieval when cumulative phonemic cues reached or exceeded the target name's uniqueness point. +1 more finding
Full summary, score breakdown and related studies → Original source
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2007-09-17
Local delivery of protease-resistant stromal cell derived factor-1 for stem cell recruitment after myocardial infarction
47/100 ✓ Peer-reviewed Clinical safety Circulation
Key finding: The combined advances of a new, protease-resistant SDF-1 and nanofiber-mediated delivery promoted recruitment of stem cells and improved cardiac function after myocardial infarction.
Full summary, score breakdown and related studies → Original source
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2007-09-14
Blood-brain barrier: ageing and microvascular disease--systematic review and meta-analysis
66/100 ✓ Peer-reviewed Lewy body dementia Neurobiology of aging
Key finding: We found 31 BBB permeability studies (1953 individuals) of normal ageing or cerebral microvascular disease. +2 more findings
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2007-09-13
Effects of PM2.5Collected from Cache Valley Utah on Genes Associated with the Inflammatory Response in Human Lung Cells
36/100 ✓ Peer-reviewed Risk factors Journal of Toxicology and Environmental Health
Key finding: Most notably, PM2.5-exposed cells showed significant gene level upregulation of activating receptors to interleukins 1 and 6 (IL-1R1 and IL-6R), as well as concomitant increases in protein. +2 more findings
Full summary, score breakdown and related studies → Original source
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2007-09-12
SorLA/LR11 regulates processing of amyloid precursor protein via interaction with adaptors GGA and PACS-1
44/100 ✓ Peer-reviewed Risk genes beyond APOE The Journal of biological chemistry
Key finding: Here, we investigated the cellular mechanisms that control intracellular trafficking of sorLA and their relevance for APP processing. +3 more findings
Full summary, score breakdown and related studies → Original source
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2007-09-11
Mild cognitive impairment in general practice: age-specific prevalence and correlate results from the German study on ageing, cognition and dementia in primary care patients (AgeCoDe)
50/100 ✓ Peer-reviewed Prevention and risk Dementia and geriatric cognitive disorders
Key finding: MCI is frequent in elderly patients of GPs. +1 more finding
Full summary, score breakdown and related studies → Original source
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2007-09-10
Hippocampal activation in adults with mild cognitive impairment predicts subsequent cognitive decline
47/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of neurology, neurosurgery, and psychiatry
Key finding: 25 older individuals with MCI performed a visual scene encoding task during fMRI scanning, and were followed clinically for at least 4 years after scanning. +3 more findings
Full summary, score breakdown and related studies → Original source
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2007-09-10
A double-blind comparison of citalopram and risperidone for the treatment of behavioral and psychotic symptoms associated with dementia
66/100 ✓ Peer-reviewed Caregiving The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
Key finding: No statistical difference was found in the efficacy of citalopram and risperidone for the treatment of either agitation or psychotic symptoms in patients with dementia. +4 more findings
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2007-09 month only
Diet and Alzheimer's disease
45/100 ✓ Peer-reviewed Prevention and risk Current neurology and neuroscience reports
Key finding: Some epidemiologic studies suggest that higher dietary intake of antioxidants, vitamins B(6), B(12), and folate, unsaturated fatty acids, and fish are related to a lower risk of AD, but reports are inconsistent. +1 more finding
Full summary, score breakdown and related studies → Original source
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2007-09 month only
Cholinesterase inhibitors in dementia with Lewy bodies: a comparative analysis
66/100 ✓ Peer-reviewed Treatments International journal of geriatric psychiatry
Key finding: All ChEIs significantly improved cognitive and neuropsychiatric measures. +4 more findings
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2007-09-01
The relationship of Parkinson disease with aging
36/100 ✓ Peer-reviewed Digital health tools Archives of neurology
Key finding: Several studies have demonstrated that advancing age is associated with a faster rate of motor progression, decreased levodopa responsiveness, more severe gait and postural impairment, and more severe cognitive impairment and the development of dementia in patients with PD.
Full summary, score breakdown and related studies → Original source
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2007-09-01
The prevalence of psychiatric symptoms and behavioural disturbances and the use of psychotropic drugs in Norwegian nursing homes
36/100 ✓ Peer-reviewed Health systems and care delivery International journal of geriatric psychiatry
Key finding: Psychiatric and behavioural symptoms are frequent in nursing homes and the rate increases with the progression of the dementia. +2 more findings
Full summary, score breakdown and related studies → Original source
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2007-09-01
Environmental exposures and gene regulation in disease etiology
40/100 ✓ Peer-reviewed Risk factors Environmental health perspectives
Key finding: The reviewed studies indicate that genetic predisposition for disease is best predicted in the context of environmental exposures. +1 more finding
Full summary, score breakdown and related studies → Original source
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2007-09-01
Efficacy and adverse effects of cholinesterase inhibitors and memantine in vascular dementia: a meta-analysis of randomised controlled trials
78/100 ✓ Peer-reviewed Treatments The Lancet. Neurology
Key finding: Three donepezil, two galantamine, one rivastigmine, and two memantine trials, comprising 3093 patients on the study drugs and 2090 patients on placebo, met the selection criteria. +1 more finding
Full summary, score breakdown and related studies → Original source
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2007-09-01
Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease
36/100 ✓ Peer-reviewed Risk genes beyond APOE Neuron
Key finding: Here, we report that hAPP mice have spontaneous nonconvulsive seizure activity in cortical and hippocampal networks, which is associated with GABAergic sprouting, enhanced synaptic inhibition, and synaptic plasticity deficits in the dentate gyrus.
Full summary, score breakdown and related studies → Original source
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2007-09-01
The role of hippocampus in the pathophysiology of bipolar disorder
36/100 ✓ Peer-reviewed Hippocampus size on brain scans Behavioural pharmacology
Key finding: Bipolar disorder (BD) is thought to be associated with abnormalities within discrete brain regions associated with emotional regulation, particularly in fronto-limbic-subcortical circuits. +4 more findings
Full summary, score breakdown and related studies → Original source
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2007-09-01
TNF-alpha inhibition as a treatment strategy for neurodegenerative disorders: new drug candidates and targets
43/100 ✓ Peer-reviewed Inflammation and the immune system Current Alzheimer research
Key finding: Most notably among these ailments are conditions linked to dementia-related neurodegenerative disorders, such as Alzheimer's disease (AD), Parkinson's disease (PD) and stroke. +3 more findings
Full summary, score breakdown and related studies → Original source
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