Newest studies

Quality of end-of-life care for dementia patients during acute hospital admission: a retrospective study in Ireland

47/100 ✓ Peer-reviewed End-of-life care General hospital psychiatry

Key finding: Individuals with dementia may be receiving different end-of-life care from those without. +1 more finding

• End-of-Life Care
• Care Services

Full summary, score breakdown and related studies → Original source

Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6

45/100 ✓ Peer-reviewed Brain tissue and pathology The EMBO journal

Key finding: Inclusions of TDP-43 are hallmarks of frontotemporal dementia and amyotrophic lateral sclerosis. +3 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Action of estrogens in the aging brain: dementia and cognitive aging

45/100 ✓ Peer-reviewed Treatments Biochimica et biophysica acta

Key finding: Menopause is associated with sharp declines in concentrations of circulating estrogens. +2 more findings

• Treatments
• Clinical Trials

Full summary, score breakdown and related studies → Original source

CSF biomarkers of Alzheimer disease in HIV-associated neurologic disease

47/100 ✓ Peer-reviewed Tau biomarkers Neurology

Key finding: HIV-associated neurologic disorders (HAND) continue to develop in many patients with HIV. +3 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Neuroinflammation in Parkinson's disease: its role in neuronal death and implications for therapeutic intervention

36/100 ✓ Peer-reviewed Inflammation and the immune system Neurobiology of disease

Key finding: In this review, we discuss potential triggers of neuroinflammation and review the strongest direct evidence that chronic neuroinflammation may have a more important role to play in PD versus other neurodegenerative diseases. +1 more finding

• Brain Biology
• Treatments
• Other Dementias

Full summary, score breakdown and related studies → Original source

Epidemiological pathology of dementia: attributable-risks at death in the Medical Research Council Cognitive Function and Ageing Study

61/100 ✓ Peer-reviewed Caregiving PLoS medicine

Key finding: Such AR estimates cannot be derived from the living population; rather they estimate the relative contribution of specific pathologies to dementia at death. +1 more finding

• Brain Biology

Full summary, score breakdown and related studies → Original source

NSAIDs prevent, but do not reverse, neuronal cell cycle reentry in a mouse model of Alzheimer disease

45/100 ✓ Peer-reviewed Risk genes beyond APOE The Journal of clinical investigation

Key finding: In transgenic mouse models of AD, CCEs are found before the onset of beta-amyloid peptide (Abeta) deposition to form senile plaques, a hallmark of AD. +3 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Amyloid-beta and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice

36/100 ✓ Peer-reviewed Genetics Proceedings of the National Academy of Sciences of the United States of America

Key finding: Within 1,275 quantified proteins, we found a massive deregulation of 24 proteins, of which one-third were mitochondrial proteins mainly related to complexes I and IV of the oxidative phosphorylation system (OXPHOS).

• Brain Biology

Full summary, score breakdown and related studies → Original source

Exogenous alpha-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells

52/100 ✓ Peer-reviewed Lewy body dementia Proceedings of the National Academy of Sciences of the United States of America

Key finding: Also, these findings support the concept that intracellular alpha-Syn aggregation is normally limited by the number of active nucleation sites present in the cytoplasm and that small quantities of alpha-Syn fibrils can alter this balance by acting as seeds for aggregation.

• Other Dementias

Full summary, score breakdown and related studies → Original source

Quantitative proteomics analysis of maternal plasma in Down syndrome pregnancies using isobaric tagging reagent (iTRAQ)

42/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Journal of biomedicine & biotechnology

Key finding: Amongst these we observed changes in betaHCG, a known screening marker for DS, indicating that our assay was functional. +2 more findings

• Down Syndrome

Full summary, score breakdown and related studies → Original source

Validation of the telephone interview for cognitive status-modified in subjects with normal cognition, mild cognitive impairment, or dementia

50/100 ✓ Peer-reviewed Caregiving Neuroepidemiology

Key finding: The extensive in-person assessment classified 83 persons with normal cognition, 42 persons with MCI, and 42 persons with dementia.

• Early Stage

Full summary, score breakdown and related studies → Original source

Mild cognitive impairment associated with limbic and neocortical Lewy body disease: a clinicopathological study

40/100 ✓ Peer-reviewed Hippocampus size on brain scans Brain : a journal of neurology

Key finding: These findings indicate that among Lewy body disease cases that pass through a mild cognitive impairment stage, any cognitive pattern or mild cognitive subtype is possible, with the attention/executive and visuospatial domains most frequently impaired.

• Early Stage
• Other Dementias

Full summary, score breakdown and related studies → Original source

Specific human astrocyte subtype revealed by affinity purified GFAP antibody; unpurified serum cross-reacts with neurofilament-L in Alzheimer

41/100 ✓ Peer-reviewed Biomarkers PloS one

Key finding: The human GFAP splice variants GFAPDelta164 and GFAPDeltaexon6 both result in a GFAP protein isoform with a unique out-of-frame carboxy-terminus that can be detected by the GFAP+1 antibody. +2 more findings

• Biomarkers
• Brain Biology

Full summary, score breakdown and related studies → Original source

Systematic review of health behavioral risks and cognitive health in older adults

58/100 ✓ Peer-reviewed Prevention and risk International psychogeriatrics

Key finding: The review demonstrates accumulating evidence supporting health behavioral effects in reducing the risk of cognitive decline and dementia. +3 more findings

• Prevention
• Risk Factors
• Lifestyle

Full summary, score breakdown and related studies → Original source

Can we do better in developing new drugs for Alzheimer's disease?

41/100 ✓ Peer-reviewed Treatments Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Their cost-effectiveness from a societal perspective has not been universally recognized, and anybody who thinks these drugs are useful for individual patients will have to agree that the improvement above the starting point of treatment is moderate. +4 more findings

• Treatments
• Policy

Full summary, score breakdown and related studies → Original source

Cerebrospinal fluid tau and ptau(181) increase with cortical amyloid deposition in cognitively normal individuals: implications for future clinical trials of Alzheimer's disease

40/100 ✓ Peer-reviewed Brain scans and imaging EMBO molecular medicine

Key finding: Together, these data suggest that changes in brain Abeta(42) metabolism and amyloid formation are early pathogenic events in AD, and that significant disruptions in CSF tau metabolism likely occur after Abeta(42) initially aggregates and increases as amyloid accumulates. +1 more finding

• Biomarkers
• Early Stage
• Brain Biology

Full summary, score breakdown and related studies → Original source

Epigenetic mechanisms in neurological diseases: genes, syndromes, and therapies

40/100 ✓ Peer-reviewed Genetics The Lancet. Neurology

Key finding: The neurological disorder most intensely studied with regard to epigenetic changes is Rett syndrome; patients with Rett syndrome have neurodevelopmental defects associated with mutations in MeCP2, which encodes the methyl CpG binding protein 2, that binds to methylated DNA.

• Genetics
• Treatments
• Other Dementias

Full summary, score breakdown and related studies → Original source

Chronic stress selectively reduces hippocampal volume in rats: a longitudinal magnetic resonance imaging study

52/100 ✓ Peer-reviewed Hippocampus size on brain scans Neuroreport

Key finding: Here, we addressed this issue by using structural magnetic resonance imaging in rats to measure the hippocampus and other brain regions before and after stress. +4 more findings

• Brain Scans

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Hippocampal volume and asymmetry in mild cognitive impairment and Alzheimer's disease: Meta-analyses of MRI studies

67/100 ✓ Peer-reviewed Hippocampus size on brain scans Hippocampus

Key finding: However, in mild cognitive impairment (MCI), the results are inconsistent. +1 more finding

• Brain Scans
• Early Stage

Full summary, score breakdown and related studies → Original source

History of falls in Parkinson disease is associated with reduced cholinergic activity

57/100 ✓ Peer-reviewed Clinical safety Neurology

Key finding: Unlike nigrostriatal dopaminergic denervation, cholinergic hypofunction is associated with fall status in Parkinson disease (PD). +4 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

Nitric oxide in cell survival: a janus molecule

36/100 ✓ Peer-reviewed Inflammation and the immune system Antioxidants & redox signaling

Key finding: This article reviews the current understanding of the cytotoxic versus cytoprotective effects of NO in the central nervous system, highlighting the Janus-faced properties of this small molecule.

• Brain Biology
• Other Dementias

Full summary, score breakdown and related studies → Original source

Occurrence and risk factors for apathy in Parkinson disease: a 4-year prospective longitudinal study

55/100 ✓ Peer-reviewed Digital health tools Journal of neurology, neurosurgery, and psychiatry

Key finding: Apathy is a persistent behavioural feature in PD with a high incidence and prevalence over time. +2 more findings

• Risk Factors
• Other Dementias

Full summary, score breakdown and related studies → Original source

Association of muscle strength with the risk of Alzheimer disease and the rate of cognitive decline in community-dwelling older persons

61/100 ✓ Peer-reviewed How common it is Archives of neurology

Key finding: During a mean follow-up of 3.6 years, 138 persons developed AD. +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Prevalence of dementia and cognitive impairment in Southeastern Spain: the Ariadna study

51/100 ✓ Peer-reviewed Disparities Acta neurologica Scandinavica

Key finding: The prevalence of dementia was low, despite a high prevalence of aMCI and CIND. +3 more findings

Full summary, score breakdown and related studies → Original source

Ethnic differences in beliefs regarding Alzheimer disease among dementia family caregivers

45/100 ✓ Peer-reviewed Disparities The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

Key finding: Increased public education about AD is needed in these communities. +1 more finding

• Caregiving
• Health Equity

Full summary, score breakdown and related studies → Original source