Newest studies

A randomized, double-blind, placebo controlled-trial of triflusal in mild cognitive impairment: the TRIMCI study

60/100 ✓ Peer-reviewed Treatments Alzheimer disease and associated disorders

Key finding: In this study, Triflusal therapy was associated with a significant lower rate of conversion to dementia that is likely to be clinically relevant. +4 more findings

• Clinical Trials
• Treatments
• Early Stage

Full summary, score breakdown and related studies → Original source

Volumetric MRI vs clinical predictors of Alzheimer disease in mild cognitive impairment

73/100 ✓ Peer-reviewed Genetics Neurology

Key finding: In moderate stages of amnestic mild cognitive impairment, common cognitive tests provide better predictive accuracy than measures of whole brain, ventricular, entorhinal cortex, or hippocampal volumes for assessing progression to Alzheimer disease.

• Early Stage
• Genetics
• Clinical Trials

Full summary, score breakdown and related studies → Original source

Health behavior changes after genetic risk assessment for Alzheimer disease: The REVEAL Study

63/100 ✓ Peer-reviewed Genetics Alzheimer disease and associated disorders

Key finding: Participants who learned they were epsilon 4 positive were significantly more likely than epsilon 4 negative participants to report AD-specific health behavior change 1 year after disclosure (adjusted odds ratio: 2.73; 95% confidence interval: 1.14, 6.54; P=0.02). +1 more finding

• Genetics
• Clinical Trials

Full summary, score breakdown and related studies → Original source

Enhanced risk for Alzheimer disease in persons with type 2 diabetes and APOE epsilon4: the Cardiovascular Health Study Cognition Study

53/100 ✓ Peer-reviewed Genetics Archives of neurology

Key finding: These data suggest that having both diabetes and APOE epsilon4 increases the risk of dementia, especially for AD and mixed AD. +1 more finding

• Genetics
• Risk Factors

Full summary, score breakdown and related studies → Original source

Protein expression of BACE1, BACE2 and APP in Down syndrome brains

42/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Amino acids

Key finding: The phenotype of DS is thought to result from overexpression of a gene or genes located on the triplicated chromosome or chromosome region. +4 more findings

• Down Syndrome
• Brain Biology
• Digital Tools

Full summary, score breakdown and related studies → Original source

The cost-effectiveness of a behavior intervention with caregivers of patients with Alzheimer's disease

61/100 ✓ Peer-reviewed Disparities Journal of the American Geriatrics Society

Key finding: The intervention provided that most scarce of caregiver commodities--time. +1 more finding

• Policy
• Caregiving
• Clinical Trials

Full summary, score breakdown and related studies → Original source

Electroencephalography and event-related potentials as biomarkers of mild cognitive impairment and mild Alzheimer's disease

45/100 ✓ Peer-reviewed Mild cognitive impairment Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: As different signature changes associated with particular stages of disease burden are identified and validated, we anticipate expanded application of qEEG as a reliable and sensitive biomarker(s) of MCI and early Alzheimer's disease. +1 more finding

• Early Stage
• Biomarkers

Full summary, score breakdown and related studies → Original source

Core candidate neurochemical and imaging biomarkers of Alzheimer's disease

52/100 ✓ Peer-reviewed Getting a diagnosis Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: A number of in vivo neurochemistry and neuroimaging techniques, which can reliably assess aspects of physiology, pathology, chemistry, and neuroanatomy, hold promise as biomarkers. +1 more finding

• Biomarkers
• Brain Scans

Full summary, score breakdown and related studies → Original source

The GSK3 hypothesis of Alzheimer's disease

40/100 ✓ Peer-reviewed Inflammation and the immune system Journal of neurochemistry

Key finding: Glycogen synthase kinase 3 (GSK3) is a constitutively active, proline-directed serine/threonine kinase that plays a part in a number of physiological processes ranging from glycogen metabolism to gene transcription. +3 more findings

• Brain Biology

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Selective intracellular release of copper and zinc ions from bis(thiosemicarbazonato) complexes reduces levels of Alzheimer disease amyloid-beta peptide

45/100 ✓ Peer-reviewed Risk genes beyond APOE The Journal of biological chemistry

Key finding: We examined the ability of a range of metal bis(thiosemicarbazonato) complexes (MII(btsc), where M=CuII or ZnII) to increase intracellular metal levels in Chinese hamster ovary cells overexpressing amyloid precursor protein (APP-CHO) and the subsequent effect on extracellular levels of amyloid-beta peptide (Abeta). +3 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Neuropsychiatric manifestations in mild cognitive impairment: a systematic review of the literature

60/100 ✓ Peer-reviewed Clinical safety Dementia and geriatric cognitive disorders

Key finding: Neuropsychiatric symptoms are common features of MCI.

• Early Stage

Full summary, score breakdown and related studies → Original source

Mapping progressive brain structural changes in early Alzheimer's disease and mild cognitive impairment

44/100 ✓ Peer-reviewed Mild cognitive impairment Neuropsychologia

Key finding: Mild cognitive impairment (MCI), a transitional state between normal aging and dementia, carries a four- to sixfold increased risk of future diagnosis of dementia. +1 more finding

• Early Stage
• Treatments

Full summary, score breakdown and related studies → Original source

Axonal alpha-synuclein aggregates herald centripetal degeneration of cardiac sympathetic nerve in Parkinson's disease

54/100 ✓ Peer-reviewed Lewy body dementia Brain : a journal of neurology

Key finding: We previously demonstrated that degeneration of the distal axons of the cardiac sympathetic nerve precedes loss of their mother neurons in the paravertebral sympathetic ganglia, suggesting distal dominant degeneration of the cardiac sympathetic nerve in PD. +2 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

Patients with MCI and N400 or P600 abnormalities are at very high risk for conversion to dementia

50/100 ✓ Peer-reviewed Mild cognitive impairment Neurology

Key finding: Abnormalities of the P600 or N400 in mild cognitive impairment are associated with an increased risk of subsequent conversion to Alzheimer disease (AD). +2 more findings

• Early Stage

Full summary, score breakdown and related studies → Original source

The clinical diagnostic utility of transcranial magnetic stimulation: report of an IFCN committee

36/100 ✓ Peer-reviewed Vascular contributions Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology

Key finding: The results of MEP measurement in the first week after stroke correlate with functional outcome. +1 more finding

• Diagnosis
• Other Dementias

Full summary, score breakdown and related studies → Original source

Melatonin and bright-light treatment for rest-activity disruption in institutionalized patients with Alzheimer's disease

70/100 ✓ Peer-reviewed Digital health tools Journal of the American Geriatrics Society

Key finding: Light treatment alone did not improve nighttime sleep, daytime wake, or rest-activity rhythm. +3 more findings

• Treatments
• Clinical Trials

Full summary, score breakdown and related studies → Original source

The tauopathy associated with mutation +3 in intron 10 of Tau: characterization of the MSTD family

62/100 ✓ Peer-reviewed Digital health tools Brain : a journal of neurology

Key finding: Tau haplotyping indicated that specific haplotypes of the wild-type allele may act as modifiers of disease presentation.

• Genetics
• Caregiving

Full summary, score breakdown and related studies → Original source

Biomarkers for early detection of Alzheimer pathology

41/100 ✓ Peer-reviewed Brain scans and imaging Neuro-Signals

Key finding: The increasing prevalence of Alzheimer's disease and the devastating consequences of late-life dementia motivates the drive to develop diagnostic biomarkers to reliably identify the pathology associated with this disorder.

• Brain Scans
• Biomarkers
• Diagnosis

Full summary, score breakdown and related studies → Original source

Oxidative stress and neurotoxicity

36/100 ✓ Peer-reviewed Disease mechanisms Chemical research in toxicology

Key finding: There is increasing awareness of the ubiquitous role of oxidative stress in neurodegenerative disease states. +4 more findings

• Brain Biology
• Other Dementias

Full summary, score breakdown and related studies → Original source

Improvement in behavioural symptoms in patients with moderate to severe Alzheimer's disease by memantine: a pooled data analysis

53/100 ✓ Peer-reviewed Treatments International Journal of Geriatric Psychiatry

Key finding: At weeks 12 and 24/28, ITT analysis demonstrated that memantine treatment produced statistically significant benefits over placebo treatment in NPI total score (p=0.001 and p=0.008), and in NPI single items: delusions (p=0.007 week 12, p=0.001 week 24/28), hallucinations (p=0.037 week 12), agitation/aggression (p=0.001 week 12, p=0.001 week 24/28), and irritability/lability (p=0.005 week 24/28), LOCF population. +3 more findings

• Treatments

Full summary, score breakdown and related studies → Original source

Direct voxel-based comparison between grey matter hypometabolism and atrophy in Alzheimer's disease

40/100 ✓ Peer-reviewed Brain scans and imaging Brain

Key finding: However, the direct comparison revealed marked regional variability in the relationship between hypometabolism and atrophy. +2 more findings

• Brain Scans

Full summary, score breakdown and related studies → Original source

Autophagy, amyloidogenesis and Alzheimer disease

36/100 ✓ Peer-reviewed Disease mechanisms Journal of cell science

Key finding: Recent evidence has shown that the amyloid beta peptide is generated from amyloid beta precursor protein (APP) during autophagic turnover of APP-rich organelles supplied by both autophagy and endocytosis.

• Brain Biology

Full summary, score breakdown and related studies → Original source

Neuronal death and survival under oxidative stress in Alzheimer and Parkinson diseases

36/100 ✓ Peer-reviewed Risk factors CNS & neurological disorders drug targets

Key finding: There is recent evidence suggesting that several known gene mutations in causing familial AD (amyloid beta protein precursor, presenilin-1, or presenilin-2 gene) and familial PD (Parkin, PINK-1, or DJ-1 gene) are associated with increased oxidative stress. +3 more findings

• Brain Biology
• Genetics
• Other Dementias

Full summary, score breakdown and related studies → Original source

Nanomaterials and nanoparticles: sources and toxicity

36/100 ✓ Peer-reviewed Risk factors Biointerphases

Key finding: Significantly, technological advancement has also changed the character of particulate pollution, increasing the proportion of nanometer-sized particles--"nanoparticles"--and expanding the variety of chemical compositions. +1 more finding

Full summary, score breakdown and related studies → Original source

Disruption of large-scale brain systems in advanced aging

43/100 ✓ Peer-reviewed Brain scans and imaging Neuron

Key finding: Furthermore, correlation reductions were severe in older adults free from Alzheimer's disease (AD) pathology as determined by amyloid imaging, suggesting that functional disruptions were not the result of AD. +2 more findings

Full summary, score breakdown and related studies → Original source