Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 24,926–24,950 of 27,380 studies, newest first · page 998 of 1096.
March 2002 7
-
2002-03-01
Reading level attenuates differences in neuropsychological test performance between African American and White elders
49/100 ✓ Peer-reviewed Disparities Journal of the International Neuropsychological Society : JINS
Key finding: A MANOVA revealed that African American elders obtained significantly lower scores than Whites on measures of word list learning and memory, figure memory, abstract reasoning, fluency, and visuospatial skill even though the groups were matched on years of education. +2 more findings
Full summary, score breakdown and related studies → Original source
-
2002-03-01
Antemortem MRI findings correlate with hippocampal neuropathology in typical aging and dementia
58/100 ✓ Peer-reviewed Getting a diagnosis Neurology
Key finding: Individuals with an isolated pathologic diagnosis of AD, hippocampal sclerosis, frontotemporal degeneration, and neurofibrillary tangle--only degeneration usually had substantial hippocampal atrophy, while those with changes of typical aging did not. +1 more finding
Full summary, score breakdown and related studies → Original source
-
2002-03-01
Mortality associated with Down's syndrome in the USA from 1983 to 1997: a population-based study
61/100 ✓ Peer-reviewed Getting a diagnosis Lancet (London, England)
Key finding: Reduced exposure to environmental factors that contribute to cancer risk, tumour-suppressor genes on chromosome 21, or a slower rate of replication or higher likelihood of apoptosis in Down's syndrome cells, could be possible reasons for paucity of cancer in people with Down's syndrome. +3 more findings
Full summary, score breakdown and related studies → Original source
-
2002-03-01
Central auditory dysfunction may precede the onset of clinical dementia in people with probable Alzheimer's disease
57/100 ✓ Peer-reviewed Prevention and risk Journal of the American Geriatrics Society
Key finding: Central auditory speech-processing deficits may be an early manifestation of probable Alzheimer's disease and may precede the onset of dementia diagnosis by many years.
Full summary, score breakdown and related studies → Original source
-
2002-03-01
Age at onset in two common neurodegenerative diseases is genetically controlled
53/100 ✓ Peer-reviewed Genetics American journal of human genetics
Key finding: For PD, significant evidence for linkage to AAO was found on chromosome 1p (LOD = 3.41). +1 more finding
Full summary, score breakdown and related studies → Original source
-
2002-03-01
Two types of sporadic cerebral amyloid angiopathy
47/100 ✓ Peer-reviewed Genetics Journal of neuropathology and experimental neurology
Key finding: The ratio of CAA-Type 2 to CAA-Type 1 cases does not shift significantly with respect to the severity of AD-related beta-amyloidosis, with respect to degrees of CAA-severity, or with increasing age. +1 more finding
Full summary, score breakdown and related studies → Original source
-
2002-03-01
The GPCOG: a new screening test for dementia designed for general practice
49/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of the American Geriatrics Society
Key finding: The General Practitioner Assessment of Cognition (GPCOG) consists of cognitive test items and historical questions asked of an informant. +3 more findings
Full summary, score breakdown and related studies → Original source
February 2002 14
-
2002-02-26
Impaired retention of spatial memory after transection of longitudinally oriented axons of hippocampal CA3 pyramidal cells
36/100 ✓ Peer-reviewed Hippocampus size on brain scans Proceedings of the National Academy of Sciences of the United States of America
Key finding: No significant impairment occurred in rats with longitudinally oriented cuts, or in animals with ibotenic acid-induced lesions of similar magnitude. +1 more finding
Full summary, score breakdown and related studies → Original source
-
2002-02-22
Intracellular amyloid-beta 1-42, but not extracellular soluble amyloid-beta peptides, induces neuronal apoptosis
42/100 ✓ Peer-reviewed Risk genes beyond APOE The Journal of biological chemistry
Key finding: A typical histological hallmark of AD is the extracellular deposition of beta-amyloid peptide (A beta), which is produced by the cleavage of the amyloid precursor protein (APP). +3 more findings
Full summary, score breakdown and related studies → Original source
-
2002-02-01
alpha-Synuclein is phosphorylated in synucleinopathy lesions
36/100 ✓ Peer-reviewed Brain tissue and pathology Nature cell biology
Key finding: These results highlight the importance of phosphorylation of filamentous proteins in the pathogenesis of neurodegenerative disorders.
Full summary, score breakdown and related studies → Original source
-
2002-02-01
Development and implementation of an inpatient acute palliative care service
50/100 ✓ Peer-reviewed End-of-life care Journal of palliative medicine
Key finding: Mount Carmel Health has developed an APCS and APCU integrated into the mainstream of each of its hospitals, providing an opportunity for a more appropriate focus on end-of-life issues for patients with poor prognoses, intense medical needs, and complex family issues. +1 more finding
Full summary, score breakdown and related studies → Original source
-
2002-02-01
Delirium predicts 12-month mortality
45/100 ✓ Peer-reviewed Clinical safety Archives of internal medicine
Key finding: Delirium is an independent marker for increased mortality among older medical inpatients during the 12 months after hospital admission. +2 more findings
Full summary, score breakdown and related studies → Original source
-
2002-02-01
Under-recruitment and nonselective recruitment: dissociable neural mechanisms associated with aging
36/100 ✓ Peer-reviewed Prevention trials Neuron
Key finding: Older adults showed less activity in anterior-ventral regions associated with controlled use of semantic information. +2 more findings
Full summary, score breakdown and related studies → Original source
-
2002-02-01
[alpha]-Secretase ADAM10 as well as [alpha]APPs is reduced in platelets and CSF of Alzheimer disease patients
44/100 ✓ Peer-reviewed Risk genes beyond APOE Molecular medicine (Cambridge, Mass.)
Key finding: The present study addresses the following major questions: 1) Are the levels of an alpha-secretase candidate (i.e., ADAM10) reduced in accessible cells of Alzheimer Disease (AD) patients? 2) Are ADAM10 levels in the peripheral cells of AD patients related to a concomitant decrease in alpha APPs? +3 more findings
Full summary, score breakdown and related studies → Original source
-
2002-02-01
Time course of the development of Alzheimer-like pathology in the doubly transgenic PS1+APP mouse
45/100 ✓ Peer-reviewed Risk genes beyond APOE Experimental neurology
Key finding: The early A(beta) deposits were found to be primarily composed of fibrillar A(beta) and resembled compact amyloid plaques. +3 more findings
Full summary, score breakdown and related studies → Original source
-
2002-02-01
A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing
45/100 ✓ Peer-reviewed Risk genes beyond APOE Biochemistry
Key finding: Using C-terminally tagged APP derivatives, we have identified by amino-terminal sequencing a novel cleavage site of APP, at Leu-49, distal to the gamma-secretase site. +3 more findings
Full summary, score breakdown and related studies → Original source
-
2002-02-01
Gender differences in burden and depression among informal caregivers of demented elders in the community
47/100 ✓ Peer-reviewed Caregiving International journal of geriatric psychiatry
Key finding: Adequate assistance must be given to women caregivers to ensure that they are not strained beyond what is clinically healthy. +2 more findings
Full summary, score breakdown and related studies → Original source
-
2002-02-01
Visual hallucinations in Lewy body disease relate to Lewy bodies in the temporal lobe
56/100 ✓ Peer-reviewed Getting a diagnosis Brain : a journal of neurology
Key finding: Consensus opinion characterizes dementia with Lewy bodies (DLB) as a progressive dementing illness, with significant fluctuations in cognition, visual hallucinations and/or parkinsonism. +3 more findings
Full summary, score breakdown and related studies → Original source
-
2002-02-01
Participation in cognitively stimulating activities and risk of incident Alzheimer disease
70/100 ✓ Peer-reviewed Getting a diagnosis JAMA
Key finding: These results suggest that frequent participation in cognitively stimulating activities is associated with reduced risk of AD. +4 more findings
Full summary, score breakdown and related studies → Original source
-
2002-02-01
Plasma homocysteine as a risk factor for dementia and Alzheimer's disease
69/100 ✓ Peer-reviewed Getting a diagnosis The New England journal of medicine
Key finding: An increased plasma homocysteine level is a strong, independent risk factor for the development of dementia and Alzheimer's disease. +2 more findings
Full summary, score breakdown and related studies → Original source
-
2002-02-01
Use of lipid-lowering agents, indication bias, and the risk of dementia in community-dwelling elderly people
59/100 ✓ Peer-reviewed Prevention and risk Archives of neurology
Key finding: Lipid-lowering agent use was associated with a lower risk of dementia, and specifically of Alzheimer disease, in those younger than 80 years. +4 more findings
Full summary, score breakdown and related studies → Original source
January 2002 4
-
2002-01-31
Estrogen lowers Alzheimer beta-amyloid generation by stimulating trans-Golgi network vesicle biogenesis
43/100 ✓ Peer-reviewed Risk genes beyond APOE The Journal of biological chemistry
Key finding: The biological basis for these effects remains unknown. +3 more findings
Full summary, score breakdown and related studies → Original source
-
2002-01-01
Research and Development of Donepezil Hydrochloride, a New Type of Acetylcholinesterase Inhibitor
40/100 ✓ Peer-reviewed Treatments The Japanese Journal of Pharmacology
Key finding: During the study, by chance we found a seed compound. +2 more findings
Full summary, score breakdown and related studies → Original source
-
2002 year only
Co-morbidity associated with dementia
50/100 ✓ Peer-reviewed Risk factors American journal of Alzheimer's disease and other dementias
Key finding: After adjusting for age, race, and gender, persons with Alzheimer's disease and dementia associated with medical conditions were less likely to be diagnosed with hypertension, diabetes, congestive heart failure, and atrial fibrillation than were controls. +4 more findings
Full summary, score breakdown and related studies → Original source
-
2002 year only
Cerebrospinal fluid phospho-tau, total tau and beta-amyloid(1-42) in the differentiation between Alzheimer's disease and vascular dementia
45/100 ✓ Peer-reviewed Tau biomarkers Dementia and geriatric cognitive disorders
Key finding: Compared with the controls, tau levels were significantly increased in possible AD, probable AD, AD with CVD and probable VaD. +3 more findings
Full summary, score breakdown and related studies → Original source
Browse the library by subject, with the full score breakdown →