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44/100

✓ Peer-reviewed alzhub usefulness score 44 out of 100. Risk genes beyond APOE

Topic: Brain proteins, microglia and lab models

SorLA has been recognized as a novel sorting receptor that regulates trafficking and processing of the amyloid precursor protein (APP) and that represents a significant risk factor for sporadic Alzheimer disease. Here, we investigated the cellular mechanisms that control intracellular trafficking of sorLA and their relevance for APP processing. We demonstrate that sorLA acts as a retention factor for APP in trans-Golgi compartments/trans-Golgi network, preventing release of the precursor into regular processing pathways.

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APA 7th

Schmidt, V., Sporbert, A., Rohe, M., Reimer, T., Rehm, A., Andersen, O. M., et al. (2007). SorLA/LR11 regulates processing of amyloid precursor protein via interaction with adaptors GGA and PACS-1. The Journal of biological chemistry. https://doi.org/10.1074/jbc.m705073200

Vancouver

Schmidt V, Sporbert A, Rohe M, Reimer T, Rehm A, Andersen OM, et al. SorLA/LR11 regulates processing of amyloid precursor protein via interaction with adaptors GGA and PACS-1. The Journal of biological chemistry. 2007. doi:10.1074/jbc.m705073200. PMID: 17855360.

BibTeX

@article{schmidt2007-17855360,
  author  = {Schmidt, V. and Sporbert, A. and Rohe, M. and Reimer, T. and Rehm, A. and Andersen, O. M. and Willnow, T. E.},
  title   = {{SorLA/LR11 regulates processing of amyloid precursor protein via interaction with adaptors GGA and PACS-1}},
  journal = {The Journal of biological chemistry},
  year    = {2007},
  doi     = {10.1074/jbc.m705073200},
  pmid    = {17855360},
  url     = {https://doi.org/10.1074/jbc.m705073200}
}

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.

Key findings

Here, we investigated the cellular mechanisms that control intracellular trafficking of sorLA and their relevance for APP processing.
We demonstrate that sorLA acts as a retention factor for APP in trans-Golgi compartments/trans-Golgi network, preventing release of the precursor into regular processing pathways.
Proper localization and activity of sorLA are dependent on functional interaction with GGA and PACS-1, adaptor proteins involved in protein transport to and from the trans-Golgi network.
Aberrant targeting of sorLA to the recycling compartment or the plasma membrane causes faulty APP trafficking and imbalance in non-amyloidogenic and amyloidogenic processing fates.

Why it matters

The sorting receptor sorLA was shown to hold amyloid precursor protein in the trans-Golgi compartments, preventing it from entering normal processing pathways, and this depended on interactions with the adaptor proteins GGA and PACS-1. This is cell-based mechanistic research and does not demonstrate a therapy or cure.

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Study details

Evidence strengthLow

How this study scored 44/100

Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (The Journal of biological chemistry)
Journal's citation record	4 / 4	Journal of Biological Chemistry: journal h-index 780 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	1 / 5	2007 — within 20 year(s) of the newest study here
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	0 / 3	Not stated whether this was studied in people — scores zero (not stated in the record — scored 0)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	5 / 7	Cited 183 times (OpenAlex, 2026-10-10)
Citations per year	3 / 5	8.7 citations a year over 21 year(s) since 2007
Impact for its field and year	4 / 6	Cited 8.7× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	2 / 6	Cited by 6 other studies in this library
Still being cited	1 / 4	Cited 13 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	3 / 4	Last-listed author Thomas E. Willnow: h-index 79 (OpenAlex, whole career)
Institution's track record	1 / 3	Max Delbrück Center: institution h-index 723 (OpenAlex)
Multi-centre collaboration	0 / 3	OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete)
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 17855360)
Free to read	0 / 2	Behind a paywall — scores zero
Total	44 / 100	—

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