Newest studies

Altered functional connectivity in early Alzheimer's disease: a resting-state fMRI study

36/100 ✓ Peer-reviewed Brain scans and imaging Human brain mapping

Key finding: Furthermore, recent resting-state functional magnetic resonance imaging (fMRI) studies have also shown that low-frequency (<0.08 Hz) fluctuations (LFF) of the blood oxygenation level-dependent signals were abnormal in several brain areas of AD patients. +3 more findings

• Brain Scans

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Longitudinal, quantitative assessment of amyloid, neuroinflammation, and anti-amyloid treatment in a living mouse model of Alzheimer's disease enabled by positron emission tomography

52/100 ✓ Peer-reviewed Brain scans and imaging The Journal of neuroscience : the official journal of the Society for Neuroscience

Key finding: PET investigation for Tg mice over an extended range of ages, including longitudinal assessments, demonstrated age-dependent increase in radioligand binding consistent with progressive amyloid accumulation. +2 more findings

• Treatments
• Brain Scans
• Brain Biology

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8-plex quantitation of changes in cerebrospinal fluid protein expression in subjects undergoing intravenous immunoglobulin treatment for Alzheimer's disease

52/100 ✓ Peer-reviewed Genetics Proteomics

Key finding: This technology which was first applied to a test mixture consisting of eight proteins and resulted in accurate quantitation, has the potential to increase throughput of analysis for quantitative shotgun proteomics experiments when compared to 2- and 4-plex methods. +2 more findings

• Treatments
• Biomarkers

Full summary, score breakdown and related studies → Original source

HIV-associated cryptococcal meningitis

63/100 ✓ Peer-reviewed Risk factors AIDS

Key finding: There was a significant clustering of isolates from African compared with European patients, suggesting that the patients had acquired their isolates long before the development of clinical disease. +4 more findings

• Clinical Trials

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EYE ON WASHINGTON

24/100 ✓ Peer-reviewed Health systems and care delivery Oncology Times

Key finding: Stark said. “These plans typically charge more than traditional Medicare for a large number of services—everything from home health care to hospital stays and chemotherapy drugs to durable medical equipment. +4 more findings

• Care Services
• Policy

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Second hip fracture in older men and women: the Framingham Study

54/100 ✓ Peer-reviewed Long-term cohort studies Archives of internal medicine

Key finding: Older persons with hip fractures remain at increased risk of subsequent hip fractures. +3 more findings

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Three-dimensional gray matter atrophy mapping in mild cognitive impairment and mild Alzheimer disease

55/100 ✓ Peer-reviewed Cognitive tests and assessment Archives of neurology

Key finding: Alzheimer disease (AD) is the most common form of dementia worldwide. +3 more findings

• Early Stage

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The relationship between cerebrospinal fluid biomarkers and depression in elderly women

44/100 ✓ Peer-reviewed Tau biomarkers The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

Key finding: Cerebrospinal fluid (CSF) biomarkers including the 42 amino-acid form of beta-amyloid (Abeta42), total tau protein (T-tau), and the CSF/serum albumin ratio are markers of brain pathology and metabolism. +3 more findings

• Biomarkers

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Paradoxical upregulation of glutamatergic presynaptic boutons during mild cognitive impairment

45/100 ✓ Peer-reviewed Mild cognitive impairment The Journal of neuroscience : the official journal of the Society for Neuroscience

Key finding: The identification of specific markers of glutamatergic neurons now allows an assessment of the structural involvement of the glutamatergic system across progressive stages of the Alzheimer's pathology, an opportunity not afforded by previously used neurochemical approaches. +4 more findings

• Early Stage
• Brain Biology

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The Lewy body in Parkinson's disease: molecules implicated in the formation and degradation of alpha-synuclein aggregates

46/100 ✓ Peer-reviewed Lewy body dementia Neuropathology : official journal of the Japanese Society of Neuropathology

Key finding: Recent studies have suggested that oligomers and protofibrils of alpha-synuclein are cytotoxic, and that LBs may represent a cytoprotective mechanism in PD.

• Other Dementias

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Tooth loss, dementia and neuropathology in the Nun study

59/100 ✓ Peer-reviewed Risk factors Journal of the American Dental Association (1939)

Key finding: Participants with the fewest teeth had the highest risk of prevalence and incidence of dementia.

• Brain Biology
• Risk Factors

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Potassium channel antibody associated encephalopathy presenting with a frontotemporal dementia like syndrome

41/100 ✓ Peer-reviewed Digital health tools Archives of neurology

Key finding: An 82-year-old man presented with progressive changes in personality, social conduct, and executive function with preservation of memory, deteriorating from baseline to requiring acute hospitalization within 6 months.

• Other Dementias

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Pathological correlates of dementia in a longitudinal, population-based sample of aging

66/100 ✓ Peer-reviewed How common it is Annals of neurology

Key finding: Previously published community- or population-based studies of brain aging and dementia with autopsy were restricted to a single sex, a single ethnic group, Roman Catholic clergy, or focused pathological assessments. +1 more finding

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Education delays accelerated decline on a memory test in persons who develop dementia

63/100 ✓ Peer-reviewed Caregiving Neurology

Key finding: As predicted by the cognitive reserve hypothesis, higher education delays the onset of accelerated cognitive decline; once it begins it is more rapid in persons with more education.

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Conscientiousness and the incidence of Alzheimer disease and mild cognitive impairment

61/100 ✓ Peer-reviewed Caregiving Archives of general psychiatry

Key finding: Level of conscientiousness is a risk factor for Alzheimer disease. +4 more findings

• Risk Factors
• Early Stage
• Brain Biology

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Baseline predictors of rates of hippocampal atrophy in mild cognitive impairment

65/100 ✓ Peer-reviewed Brain scans and imaging Neurology

Key finding: Rates of hippocampal atrophy (%/year) were 0.0 +/- 0.8 in the absent, 1.7 +/- 0.4 in the moderate, and 3.6 +/- 1.0 in the severe (mean +/- SD) tertile. +1 more finding

• Brain Scans
• Early Stage
• Genetics

Full summary, score breakdown and related studies → Original source

Divergent social functioning in behavioral variant frontotemporal dementia and Alzheimer disease: reciprocal networks and neuronal evolution

44/100 ✓ Peer-reviewed Brain scans and imaging Alzheimer disease and associated disorders

Key finding: Our most recent findings suggest that bvFTD and AD target distinct, anticorrelated intrinsic connectivity networks and that bvFTD-related VEN injury occurs throughout the ACC-FI network. +1 more finding

• Other Dementias

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The significance of medial temporal lobe atrophy: a postmortem MRI study in the very old

53/100 ✓ Peer-reviewed Brain scans and imaging Neurology

Key finding: Medial temporal lobe atrophy (MTA) on postmortem MRI is sensitive to primary degenerative hippocampal pathology in the very old, but not specific for Alzheimer-type pathology. +4 more findings

• Brain Scans
• Brain Biology

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Disease-modifying therapies for Alzheimer disease: challenges to early intervention

49/100 ✓ Peer-reviewed Brain scans and imaging Neurology

Key finding: Epidemiologically based risk factors or biomarkers can be used to enrich trials and increase the likelihood of disease occurrence during the trial. +4 more findings

• Treatments
• Brain Scans

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Reduced hippocampal functional connectivity in Alzheimer disease

47/100 ✓ Peer-reviewed Brain scans and imaging Archives of neurology

Key finding: These findings suggest a functional disconnection between the hippocampus and other brain regions in patients with Alzheimer disease. +1 more finding

• Brain Scans

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Focal cortical presentations of Alzheimer's disease

58/100 ✓ Peer-reviewed Getting a diagnosis Brain : a journal of neurology

Key finding: To determine the frequency of Alzheimer's disease (AD) pathology in patients presenting with progressive focal cortical syndromes, notably posterior cortical atrophy (PCA), corticobasal syndrome (CBS), behavioural variant frontotemporal dementia (bvFTD), progressive non-fluent aphasia (PNFA) (or a mixed aphasia) and semantic dementia (SD); and to compare the age of onset, evolution and prognosis in patients with focal cortical presentations of AD versus more typical AD and those with non AD pathology.

Full summary, score breakdown and related studies → Original source

Education and dementia: what lies behind the association?

56/100 ✓ Peer-reviewed Prevention and risk Neurology

Key finding: The association between low education and dementia is probably not explained by the unhealthy lifestyles of the less educated compared with higher educated persons. +3 more findings

• Risk Factors

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The role of circadian clock genes in mental disorders

40/100 ✓ Peer-reviewed Drug development Dialogues in Clinical Neuroscience

Key finding: The study of molecular clock mechanisms in psychiatric disorders is gaining significant interest due to data suggesting that a misalignment between the endogenous circadian system and the sleep-wake cycle might contribute to the clinical status of patients suffering from a variety of psychiatric disorders. +3 more findings

• Genetics

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Adenosine A2A receptors and brain injury: broad spectrum of neuroprotection, multifaceted actions and "fine tuning" modulation

36/100 ✓ Peer-reviewed Vascular contributions Progress in neurobiology

Key finding: Pharmacological, neurochemical and molecular/genetic approaches to the complex actions of A2A receptors in different cellular elements suggest that A2A receptor activation can be detrimental or protective after brain insults, depending on the nature of brain injury and associated pathological conditions.

• Other Dementias

Full summary, score breakdown and related studies → Original source

Potential interaction between the GARS-AIRS-GART Gene and CP2/LBP-1c/LSF transcription factor in Down syndrome-related Alzheimer disease

26/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Cellular and molecular neurobiology

Key finding: Factors implicated in neurodevelopment or neurodegeneration were the focus of attention, and mining of human (T1Dbase) and murine (GNF) expression databases revealed information on the regional distribution of these factors and their relative abundance vis-a-vis GARS-AIRS-GART. +2 more findings

• Down Syndrome
• Genetics

Full summary, score breakdown and related studies → Original source