Newest studies

A new amyloid beta variant favoring oligomerization in Alzheimer's-type dementia

50/100 ✓ Peer-reviewed Brain scans and imaging Annals of neurology

Key finding: The E693Delta mutation has been suggested as a cause of dementia because of enhanced formation of synaptotoxic Abeta oligomers. +1 more finding

• Brain Biology
• Genetics

Full summary, score breakdown and related studies → Original source

Vascular cognitive impairment: current concepts and clinical developments

40/100 ✓ Peer-reviewed Vascular contributions The Lancet. Neurology

Key finding: Despite the heterogeneity of the VCI construct, some clinical patterns can be discerned, which enable subtypes, such as mixed dementia and VCI-no dementia, to be recognised. +4 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

The brain's default network: anatomy, function, and relevance to disease

57/100 ✓ Peer-reviewed Brain scans and imaging Annals of the New York Academy of Sciences

Thirty years of brain imaging research has converged to define the brain's default network-a novel and only recently appreciated brain system that participates in internal modes of cognition.

Full summary, score breakdown and related studies → Original source

Mosaicism for trisomy 21 in a patient with young-onset dementia: a case report and brief literature review

42/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Archives of neurology

Key finding: As mosaicism for trisomy 21 can present with no or minimal manifestations of Down syndrome, it may be underdiagnosed as a cause of early-onset AD.

• Down Syndrome

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Novel MRI techniques in the assessment of dementia

41/100 ✓ Peer-reviewed Digital health tools European journal of nuclear medicine and molecular imaging

Key finding: Besides their diagnostic use, MRI and DTI will broaden our understanding of the pathophysiology of AD and the structural and functional basis of normal cognition. +2 more findings

• Brain Scans

Full summary, score breakdown and related studies → Original source

Tailored activities to manage neuropsychiatric behaviors in persons with dementia and reduce caregiver burden: a randomized pilot study

56/100 ✓ Peer-reviewed Caregiving The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

Key finding: Tailoring activities to the capabilities of dementia patients and training families in activity use resulted in clinically relevant benefits for patients and caregivers.

• Caregiving
• Clinical Trials

Full summary, score breakdown and related studies → Original source

Dementia and survival in Parkinson disease: a 12-year population study

69/100 ✓ Peer-reviewed Getting a diagnosis Neurology

Key finding: Dementia is a key part of survival in Parkinson disease and must be planned for in services for this condition.

• Other Dementias

Full summary, score breakdown and related studies → Original source

Memory impairment, executive dysfunction, and intellectual decline in preclinical Alzheimer's disease

65/100 ✓ Peer-reviewed Getting a diagnosis Journal of the International Neuropsychological Society : JINS

Key finding: We found that declines in performance on tests of episodic memory accelerated 7 years before diagnosis. +1 more finding

• Early Stage

Full summary, score breakdown and related studies → Original source

Effectiveness of cholinesterase inhibitors and memantine for treating dementia: evidence review for a clinical practice guideline

68/100 ✓ Peer-reviewed Treatments Annals of internal medicine

Key finding: Treatment of dementia with cholinesterase inhibitors and memantine can result in statistically significant but clinically marginal improvement in measures of cognition and global assessment of dementia.

• Treatments

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Prevalence of cognitive impairment without dementia in the United States

67/100 ✓ Peer-reviewed Getting a diagnosis Annals of internal medicine

Key finding: Cognitive impairment without dementia is more prevalent in the United States than dementia, and its subtypes vary in prevalence and outcomes. +1 more finding

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Incorporating ethnicity into genetic risk assessment for Alzheimer disease: the REVEAL study experience

57/100 ✓ Peer-reviewed Treatments Genetics in medicine : official journal of the American College of Medical Genetics

Key finding: The Risk Evaluation and Education for Alzheimer Disease study provides an instructive example of a process to develop risk assessment protocols that are sensitive to the implications of genetic testing for multiple ethnic groups with differing levels of risk.

• Genetics
• Health Equity
• Clinical Trials

Full summary, score breakdown and related studies → Original source

The views of Alzheimer disease patients and their study partners on proxy consent for clinical trial enrollment

61/100 ✓ Peer-reviewed Treatments The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

Key finding: Patients and their study partners who were enrolled in a clinical trial supported proxy consent both for themselves and as a matter of policy. +1 more finding

• Clinical Trials

Full summary, score breakdown and related studies → Original source

Genome-wide association studies in Alzheimer disease

46/100 ✓ Peer-reviewed Genetics Archives of neurology

Key finding: Although all have relevance to biological mechanisms that may be associated with AD pathogenesis, they await replication in large representative populations. +2 more findings

• Genetics

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Fatty acids, lipid metabolism and Alzheimer pathology

42/100 ✓ Peer-reviewed Genetics European journal of pharmacology

Key finding: The cause of Alzheimer's disease is still unknown and there is no cure for the disease yet despite 100 years of extensive research. +4 more findings

• Genetics
• Risk Factors
• Lifestyle

Full summary, score breakdown and related studies → Original source

The Sydney multicenter study of Parkinson's disease: The inevitability of dementia at 20 years

54/100 ✓ Peer-reviewed Lewy body dementia Movement Disorders

After 20 years follow-up of newly diagnosed patients with Parkinson's disease (PD), 100 of 136 (74%) have died.

• Other Dementias

Full summary, score breakdown and related studies → Original source

TDP-43 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis

64/100 ✓ Peer-reviewed Disease mechanisms Science

Key finding: The function of TDP-43 in the nervous system is uncertain, and a mechanistic role in neurodegeneration remains speculative. +4 more findings

• Genetics
• Brain Biology
• Other Dementias

Full summary, score breakdown and related studies → Original source

Donepezil in patients with subcortical vascular cognitive impairment: a randomised double-blind trial in CADASIL

71/100 ✓ Peer-reviewed Treatments The Lancet. Neurology

Key finding: Cholinergic deficits might contribute to vascular cognitive impairment. +3 more findings

• Treatments
• Clinical Trials
• Other Dementias

Full summary, score breakdown and related studies → Original source

Independent inhibition of Alzheimer disease beta- and gamma-secretase cleavage by lowered cholesterol levels

41/100 ✓ Peer-reviewed Risk genes beyond APOE The Journal of biological chemistry

Key finding: In addition, growing evidence suggests a role of cholesterol in Alzheimer disease pathology and Abeta generation. +3 more findings

• Risk Factors

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Disturbance of nuclear and cytoplasmic TAR DNA-binding protein (TDP-43) induces disease-like redistribution, sequestration, and aggregate formation

53/100 ✓ Peer-reviewed Lewy body dementia The Journal of biological chemistry

Key finding: Here we recapitulate these pathological phenotypes in cultured cells by altering endogenous TDP-43 nuclear trafficking and by expressing mutants with defective nuclear localization (TDP-43-DeltaNLS) or nuclear export signals (TDP-43-DeltaNES). +4 more findings

• Other Dementias
• Brain Biology

Full summary, score breakdown and related studies → Original source

The Alzheimer's disease neuroimaging initiative (ADNI): MRI methods

72/100 ✓ Peer-reviewed Brain scans and imaging Journal of Magnetic Resonance Imaging

Key finding: A major effort was devoted to evaluating 3D T(1)-weighted sequences for morphometric analyses. +4 more findings

• Brain Scans
• Biomarkers

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The role of interleukin-1 in neuroinflammation and Alzheimer disease: an evolving perspective

50/100 ✓ Peer-reviewed Inflammation and the immune system Journal of neuroinflammation

Key finding: The discovery of increased IL-1 levels in patients following acute injury and in chronic neurodegenerative disease laid the foundation for two decades of research that has provided important details regarding IL-1's biology and function in the CNS. +3 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

3D characterization of brain atrophy in Alzheimer's disease and mild cognitive impairment using tensor-based morphometry

50/100 ✓ Peer-reviewed Cognitive tests and assessment NeuroImage

Key finding: Using two different TBM designs (averaging individual differences versus aligning group average templates), we compared the anatomical distribution of brain atrophy in 40 patients with Alzheimer's disease (AD), 40 healthy elderly controls, and 40 individuals with amnestic mild cognitive impairment (aMCI), a condition conferring increased risk for AD. +3 more findings

• Brain Scans
• Early Stage

Full summary, score breakdown and related studies → Original source

Validation of the Arabic version of the short Geriatric Depression Scale (GDS-15)

41/100 ✓ Peer-reviewed Digital health tools International psychogeriatrics

Key finding: The Arabic GDS is a useful measure to assess depression among community-dwelling older adults and primary care patients who do not have dementia.

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Multicenter standardized 18F-FDG PET diagnosis of mild cognitive impairment, Alzheimer's disease, and other dementias

59/100 ✓ Peer-reviewed Getting a diagnosis Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Key finding: Standardized automated analysis of (18)F-FDG PET scans may provide an objective and sensitive support to the clinical diagnosis in early dementia.

• Brain Scans
• Diagnosis
• Early Stage

Full summary, score breakdown and related studies → Original source

Rate of progression of mild cognitive impairment to dementia--meta-analysis of 41 robust inception cohort studies

71/100 ✓ Peer-reviewed How common it is Acta psychiatrica Scandinavica

Key finding: The ACR is approximately 5-10% and most people with MCI will not progress to dementia even after 10 years of follow-up.

• Early Stage

Full summary, score breakdown and related studies → Original source