Newest studies

Executive function in progressive and nonprogressive behavioral variant frontotemporal dementia

48/100 ✓ Peer-reviewed Disparities Neurology

Key finding: Contrary to some prior reports, behavioral variant frontotemporal dementia (bv-FTD) patients who progress over time are typically impaired on executive tasks at first presentation, although an important minority of true FTD patients perform normally. +2 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

Survival in Alzheimer disease: a multiethnic, population-based study of incident cases

64/100 ✓ Peer-reviewed Disparities Neurology

Key finding: Factors influencing survival in Alzheimer disease include race/ethnicity and comorbid diabetes and hypertension. +4 more findings

• Health Equity

Full summary, score breakdown and related studies → Original source

The clinical significance of subjective memory complaints in the diagnosis of mild cognitive impairment and dementia: a meta-analysis

60/100 ✓ Peer-reviewed Disparities International journal of geriatric psychiatry

Key finding: When assessed by simple questions, SMC appear to be present in the minority of those with mild cognitive impairment and dementia. +2 more findings

• Diagnosis
• Early Stage

Full summary, score breakdown and related studies → Original source

Alzheimer disease and cognitive reserve: variation of education effect with carbon 11-labeled Pittsburgh Compound B uptake

51/100 ✓ Peer-reviewed Caregiving Archives of neurology

Key finding: Uptake of carbon 11-labeled Pittsburgh Compound B ([(11)C]PiB) was measured for participants assessed between August 15, 2003, and January 8, 2008, at the Washington University Alzheimer's Disease Research Center and diagnosed either as nondemented (n = 161) or with dementia of the Alzheimer type (n = 37).

Full summary, score breakdown and related studies → Original source

Validity and reliability of the brief COPE in carers of people with dementia: the LASER-AD Study

48/100 ✓ Peer-reviewed Caregiving The Journal of nervous and mental disease

Key finding: Test-retest reliability over a year was demonstrated for emotion-focused, problem-focused, and dysfunctional subscales among carers in whom burden scores did not change significantly (r = 0.58, r = 0.72, r = 0.68; p < 0.001).

• Caregiving

Full summary, score breakdown and related studies → Original source

A critical evaluation of the Braak staging scheme for Parkinson's disease

49/100 ✓ Peer-reviewed Getting a diagnosis Annals of neurology

Key finding: We conclude that the relation between patterns of abnormal synuclein immunostaining in the human brain and the disease entity now recognized as PD remains to be determined.

• Other Dementias

Full summary, score breakdown and related studies → Original source

A three-country randomized controlled trial of a psychosocial intervention for caregivers combined with pharmacological treatment for patients with Alzheimer disease: effects on caregiver depression

62/100 ✓ Peer-reviewed Treatments The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

Key finding: Effective counseling and support interventions can reduce symptoms of depression in caregivers when patients are taking donepezil. +2 more findings

• Clinical Trials
• Treatments
• Caregiving

Full summary, score breakdown and related studies → Original source

Growth hormone secretagogue MK-677: no clinical effect on AD progression in a randomized trial

69/100 ✓ Peer-reviewed Treatments Neurology

Key finding: Despite evidence of target engagement as indicated by an increase in serum insulin-like growth factor-1, the human growth hormone secretagogue MK-677 25 mg was ineffective at slowing the rate of progression of Alzheimer disease. +1 more finding

• Clinical Trials

Full summary, score breakdown and related studies → Original source

Ginkgo biloba for prevention of dementia: a randomized controlled trial

82/100 ✓ Peer-reviewed Treatments JAMA

Key finding: In this study, G. biloba at 120 mg twice a day was not effective in reducing either the overall incidence rate of dementia or AD incidence in elderly individuals with normal cognition or those with MCI. +3 more findings

• Clinical Trials
• Early Stage
• Risk Factors

Full summary, score breakdown and related studies → Original source

Alzheimer's Disease is Type 3 Diabetes-Evidence Reviewed

32/100 ✓ Peer-reviewed Laboratory science Journal of Diabetes Science and Technology

Key finding: Reviews evidence that brain insulin/IGF-1 signaling is impaired early in Alzheimer's disease, before major clinical symptoms +3 more findings

• Brain Biology
• Risk Factors

Full summary, score breakdown and related studies → Original source

Genetics, environmental factors and the emerging role of epigenetics in neurodegenerative diseases

36/100 ✓ Peer-reviewed Risk factors Mutation research

Key finding: Several environmental factors, including, pesticides, metals, head injuries, lifestyles and dietary habits have been associated with increased disease risk or even with protection. +1 more finding

• Genetics
• Risk Factors

Full summary, score breakdown and related studies → Original source

Genome-wide association analysis reveals putative Alzheimer's disease susceptibility loci in addition to APOE

47/100 ✓ Peer-reviewed Genetics American journal of human genetics

Key finding: We identified five SNPs showing either significant or marginally significant genome-wide association with a multivariate phenotype combining affection status and onset age. +1 more finding

• Genetics

Full summary, score breakdown and related studies → Original source

Effect of copper intake on CSF parameters in patients with mild Alzheimer's disease: a pilot phase 2 clinical trial

60/100 ✓ Peer-reviewed Treatments Journal of neural transmission (Vienna, Austria : 1996)

Key finding: A plethora of reports suggest that copper (Cu) homeostasis is disturbed in Alzheimer's disease (AD). +3 more findings

• Clinical Trials
• Biomarkers
• Diagnosis

Full summary, score breakdown and related studies → Original source

Tau forms in CSF as a reliable biomarker for progressive supranuclear palsy

55/100 ✓ Peer-reviewed Brain scans and imaging Neurology

Key finding: Tau form ratio was significantly reduced in patients with PSP (0.504 +/- 0.284) when compared to age-matched controls (0.989 +/- 0.343), and to patients with other neurodegenerative conditions (range = 0.899-1.215). +1 more finding

• Biomarkers
• Other Dementias

Full summary, score breakdown and related studies → Original source

Olfactory identification deficits and MCI in a multi-ethnic elderly community sample

60/100 ✓ Peer-reviewed Hippocampus size on brain scans Neurobiology of aging

Key finding: Women (mean 26.6, S.D. 6.6) scored higher than men (mean 24.4, S.D. 7.4, p<.02), and ethnic differences were not significant after controlling for age and education. +3 more findings

• Brain Scans
• Early Stage
• Health Equity

Full summary, score breakdown and related studies → Original source

A Fragmented Memoir

28/100 ✓ Peer-reviewed Risk factors Journal of Neuropathology & Experimental Neurology

Key finding: Life experience, poetry, fiction, and neuroscience have all demonstrated the incomplete fragmentary nature of memory.

Full summary, score breakdown and related studies → Original source

Structural determinants of the cellular localization and shuttling of TDP-43

51/100 ✓ Peer-reviewed Lewy body dementia Journal of cell science

Key finding: Moreover, recent reports have shown that the protein interacts with the 3'UTRs of specific mRNAs. +2 more findings

• Other Dementias
• Brain Biology

Full summary, score breakdown and related studies → Original source

Comparison of trained clinician ratings with expert ratings of aspiration on videofluoroscopic images from a randomized clinical trial

49/100 ✓ Peer-reviewed Digital health tools Dysphagia

Key finding: Currently published literature indicates that interjudge reliability for the identification of aspiration ranges from poor to fairly good depending on the amount of training provided to clinicians. +3 more findings

• Clinical Trials

Full summary, score breakdown and related studies → Original source

Graph theoretical analysis of magnetoencephalographic functional connectivity in Alzheimer's disease

40/100 ✓ Peer-reviewed Brain scans and imaging Brain : a journal of neurology

Key finding: In this study we examined changes in the large-scale structure of resting-state brain networks in patients with Alzheimer's disease compared with non-demented controls, using concepts from graph theory. +1 more finding

Full summary, score breakdown and related studies → Original source

Mid- and late-life diabetes in relation to the risk of dementia: a population-based twin study

65/100 ✓ Peer-reviewed Brain tissue and pathology Diabetes

Key finding: We aimed to verify the association between diabetes and the risk of dementia, Alzheimer's disease, and vascular dementia in twins and to explore whether genetic and early-life environmental factors could contribute to this association. +3 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Receptor for advanced glycation end products is subjected to protein ectodomain shedding by metalloproteinases

43/100 ✓ Peer-reviewed Brain tissue and pathology The Journal of biological chemistry

Key finding: Ligand-induced up-regulation of RAGE is involved in various pathophysiological processes, including late diabetic complications and Alzheimer disease. +3 more findings

Full summary, score breakdown and related studies → Original source

Neurological and behavioral abnormalities, ventricular dilatation, altered cellular functions, inflammation, and neuronal injury in brains of mice due to common, persistent, parasitic infection

40/100 ✓ Peer-reviewed Biomarkers Journal of neuroinflammation

Key finding: Twelve months after infection, a time equivalent to middle to early elderly ages, mice had behavioral and neurological deficits, and brain MRIs showed mild to moderate ventricular dilatation. +1 more finding

• Brain Biology

Full summary, score breakdown and related studies → Original source

Diffusion tensor imaging correlates of memory and language impairments in temporal lobe epilepsy

47/100 ✓ Peer-reviewed Hippocampus size on brain scans Neurology

Key finding: The results suggest that structural compromise to multiple fiber tracts is associated with memory and language impairments in patients with temporal lobe epilepsy. +2 more findings

• Brain Scans

Full summary, score breakdown and related studies → Original source

Metabolic syndrome and risk for incident Alzheimer's disease or vascular dementia: the Three-City Study

58/100 ✓ Peer-reviewed Risk factors Diabetes care

Key finding: The observed relation between high triglycerides, diabetes, and vascular dementia emphasizes the need for detection and treatment of vascular risk factors in older individuals in order to prevent the likelihood of clinical dementia. +2 more findings

• Risk Factors
• Genetics
• Other Dementias

Full summary, score breakdown and related studies → Original source

General practitioners' experiences and understandings of diagnosing dementia: factors impacting on early diagnosis

38/100 ✓ Peer-reviewed Disparities Social science & medicine (1982)

Key finding: GPs did not consider that diagnosing dementia early was particularly important and may in fact be harmful to some patients. +4 more findings

• Diagnosis

Full summary, score breakdown and related studies → Original source