Newest studies

Relation between smoking and risk of dementia and Alzheimer disease: the Rotterdam Study

67/100 ✓ Peer-reviewed Long-term cohort studies Neurology

Key finding: We re-assessed after longer follow-up time in the large population-based cohort of the Rotterdam Study whether smoking habits and pack-years of smoking are associated with the risk of dementia, Alzheimer disease (AD), and vascular dementia (VaD). +3 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Progranulin mediates caspase-dependent cleavage of TAR DNA binding protein-43

53/100 ✓ Peer-reviewed Lewy body dementia The Journal of neuroscience : the official journal of the Society for Neuroscience

Key finding: The results suggest that abnormal metabolism of TDP-43 mediated by progranulin may play a pivotal role in neurodegeneration.

• Other Dementias
• Genetics

Full summary, score breakdown and related studies → Original source

Alcohol and cardiovascular health: the razor-sharp double-edged sword

51/100 ✓ Peer-reviewed Risk factors Journal of the American College of Cardiology

Key finding: Light to moderate alcohol consumption (up to 1 drink daily for women and 1 or 2 drinks daily for men) is associated with cardioprotective benefits, whereas increasingly excessive consumption results in proportional worsening of outcomes. +1 more finding

• Risk Factors
• Lifestyle

Full summary, score breakdown and related studies → Original source

Symptoms of dementia among adults with Down's syndrome: a qualitative study

44/100 ✓ Peer-reviewed Digital health tools Journal of intellectual disability research : JIDR

Key finding: This study highlights the similarities in the clinical presentation of dementia among the general population and people with DS with a particular emphasis on the earlier appearance of symptoms associated with the frontal lobe dysfunction among adults with DS. +1 more finding

• Down Syndrome

Full summary, score breakdown and related studies → Original source

AAC for adults with acquired neurological conditions: a review

42/100 ✓ Peer-reviewed Digital health tools Augmentative and alternative communication (Baltimore, Md. : 1985)

Key finding: The purpose of this review is to describe the state of the science of augmentative and alternative communication (AAC) for adults with acquired neurogenic communication disorders. +2 more findings

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Type 2 diabetes and risk of cognitive impairment and dementia

41/100 ✓ Peer-reviewed Caregiving Current neurology and neuroscience reports

Key finding: Even a modest effect of diabetes on cognitive function has significant public health implications. +2 more findings

• Risk Factors

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Peripheral insulin and brain structure in early Alzheimer disease

48/100 ✓ Peer-reviewed Brain scans and imaging Neurology

Key finding: Accumulating evidence suggests insulin and insulin signaling may be involved in the pathophysiology of Alzheimer disease (AD).

• Brain Scans

Full summary, score breakdown and related studies → Original source

Spatial cognition and the human navigation network in AD and MCI

46/100 ✓ Peer-reviewed Brain scans and imaging Neurology

Key finding: The navigation disability in Alzheimer disease and mild cognitive impairment (MCI) involves a selective impairment of spatial cognition and is associated with atrophy of the right-lateralized navigation network. +3 more findings

• Early Stage

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Clinical diagnostic criteria for dementia associated with Parkinson's disease

76/100 ✓ Peer-reviewed Getting a diagnosis Movement disorders : official journal of the Movement Disorder Society

Key finding: Specific criteria for the clinical diagnosis of dementia associated with PD (PD-D), however, have been lacking. +3 more findings

• Diagnosis
• Other Dementias

Full summary, score breakdown and related studies → Original source

The relationship between specific cognitive functions and falls in aging

49/100 ✓ Peer-reviewed Prevention and risk Neuropsychology

Key finding: The authors hypothesized that Speed/Executive Attention would be associated with falls. +4 more findings

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Preserving health of Alzheimer caregivers: impact of a spouse caregiver intervention

64/100 ✓ Peer-reviewed Treatments The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

Key finding: Counseling and support preserved SRH in vulnerable caregivers. +1 more finding

• Caregiving
• Clinical Trials

Full summary, score breakdown and related studies → Original source

A neuropsychological test battery for use in Alzheimer disease clinical trials

67/100 ✓ Peer-reviewed Treatments Archives of neurology

Key finding: The NTB had high test-retest reliability at 6 (Pearson product moment correlation [r] = 0.92) and 12 (r = 0.88) months. +2 more findings

• Clinical Trials

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Cognitive domain decline in healthy apolipoprotein E epsilon4 homozygotes before the diagnosis of mild cognitive impairment

51/100 ✓ Peer-reviewed Genetics Archives of neurology

Key finding: Of 214 participants, 48 showed no decline on any test, 126 showed decline on only 1 test in 1 or more domains, and 40 showed decline on 2 or more tests in 1 or more domains. +1 more finding

• Genetics
• Early Stage
• Diagnosis

Full summary, score breakdown and related studies → Original source

Mediterranean diet and Alzheimer disease mortality

58/100 ✓ Peer-reviewed Genetics Neurology

Key finding: Adherence to the Mediterranean diet (MeDi) may affect not only risk for Alzheimer disease (AD) but also subsequent disease course: Higher adherence to the MeDi is associated with lower mortality in AD. +4 more findings

• Lifestyle
• Genetics
• Risk Factors

Full summary, score breakdown and related studies → Original source

Plasma and CSF serpins in Alzheimer disease and dementia with Lewy bodies

54/100 ✓ Peer-reviewed Tau biomarkers Neurology

Key finding: Serine protease inhibitors (serpins), the acute phase reactants and regulators of the proteolytic processing of proteins, have been recognized as potential contributors to the pathogenesis of Alzheimer disease (AD). +3 more findings

• Biomarkers
• Other Dementias

Full summary, score breakdown and related studies → Original source

Increased risk of cognitive impairment or dementia in women who underwent oophorectomy before menopause

60/100 ✓ Peer-reviewed How common it is Neurology

Key finding: Women who underwent either unilateral or bilateral oophorectomy before the onset of menopause had an increased risk of cognitive impairment or dementia compared to referent women (hazard ratio [HR] = 1.46; 95% CI 1.13 to 1.90; adjusted for education, type of interview, and history of depression). +1 more finding

• Risk Factors

Full summary, score breakdown and related studies → Original source

Heritability of brain morphology related to schizophrenia: a large-scale automated magnetic resonance imaging segmentation study

45/100 ✓ Peer-reviewed Hippocampus size on brain scans Biological psychiatry

Key finding: These findings support evidence of genetic control of brain volume even in adults, particularly of hippocampal and neocortical volume and of cortical volumetric reductions being familial, but do not support measures of subcortical volumes per se as representing intermediate biologic phenotypes. +3 more findings

• Brain Scans
• Genetics

Full summary, score breakdown and related studies → Original source

Amyloid beta oligomers induce impairment of neuronal insulin receptors

36/100 ✓ Peer-reviewed Disease mechanisms FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Key finding: Using mature cultures of hippocampal neurons, a preferred model for studies of synaptic cell biology, we found that ADDLs caused a rapid and substantial loss of neuronal surface IRs specifically on dendrites bound by ADDLs. +3 more findings

• Brain Biology

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Impacts of Cd(II) on the conformation and self-aggregation of Alzheimer's tau fragment corresponding to the third repeat of microtubule-binding domain

36/100 ✓ Peer-reviewed Risk factors Biochimica et biophysica acta

Key finding: In the presence of Cd(II), the resulting R3 filaments became much smaller, as revealed by electron microscopy. +4 more findings

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Deaths: final data for 2004

48/100 ✓ Peer-reviewed Disparities PubMed

Key finding: In 2004, a total of 2,397,615 deaths were reported in the United States. +4 more findings

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Aging and Down syndrome: implications for physical therapy

37/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Physical therapy

Key finding: Exercise programs appear to have potential to positively affect the overall health of adults with DS, thereby increasing the quality of life and years of healthy life for these individuals.

• Down Syndrome

Full summary, score breakdown and related studies → Original source

Bilateral hippocampal volume increases after long-term lithium treatment in patients with bipolar disorder: a longitudinal MRI study

59/100 ✓ Peer-reviewed Hippocampus size on brain scans Psychopharmacology

Key finding: Consistent with preclinical literature supporting the neuroprotective effects of lithium, long-term treatment is associated with preservation of recollective memory function and increased hippocampal size in vivo. +2 more findings

• Brain Scans
• Treatments

Full summary, score breakdown and related studies → Original source

Inflammation, depression and dementia: are they connected?

44/100 ✓ Peer-reviewed Risk factors Neurochemical research

Key finding: This review summarises the evidence that links chronic low grade inflammation with changes in brain structure that could precipitate neurodegenerative changes associated with Alzheimer's disease and other dementias. +1 more finding

• Brain Biology
• Risk Factors

Full summary, score breakdown and related studies → Original source

Pattern of Tau forms in CSF is altered in progressive supranuclear palsy

34/100 ✓ Peer-reviewed Brain scans and imaging Neurobiology of aging

Key finding: Tau ratio 33 kDa/55 kDa was significantly decreased in patients with PSP (0.46+/-0.16) when compared to controls, including healthy subjects (1.16+/-0.46, P=0.002) and Alzheimer disease (1.38+/-0.68, P<0.001), and when compared to frontotemporal dementia (0.98+/-0.30, P=0.008) or corticobasal degeneration syndrome (0.98+/-0.48, P=0.02). +2 more findings

• Biomarkers
• Other Dementias

Full summary, score breakdown and related studies → Original source

Curcumin as "Curecumin": from kitchen to clinic

36/100 ✓ Peer-reviewed Risk factors Biochemical pharmacology

Key finding: Extensive research over the last half century has revealed several important functions of curcumin. +1 more finding

• Risk Factors

Full summary, score breakdown and related studies → Original source