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Prediction and longitudinal study of CSF biomarkers in mild cognitive impairment
Brys M, Pirraglia E, Rich K, Rolstad S, Mosconi L, Switalski R, Glodzik-Sobanska L, De Santi S et al.. Neurobiology of aging, 2007-09-24
Topic: Risk, prevention and care in population studies
Objectives To longitudinally evaluate five cerebrospinal fluid (CSF) biomarkers in the transition from mild cognitive impairment (MCI) to Alzheimer's disease (AD). Methods A baseline and 2-year follow-up clinical and CSF study of 86 subjects, including 22 MCI patients that declined to AD (MCI-AD), 43 MCI that did not deteriorate (MCI-MCI) and 21 controls (NL-NL). All subjects were studied for total and phosphorylated tau (T-tau, P-tau(231)), amyloid beta (Abeta) Abeta(42)/Abeta(40) ratio, isoprostane (IP) as well as P-tau(231)/Abeta(42/40) and T-tau/Abeta(42/40) ratios. Results At baseline and at follow-up MCI-AD showed higher levels P-tau(231), T-tau, IP, P-tau(231)/Abeta(42/40) and T-tau/Abeta(42/40) ratios and lower Abeta(42)/Abeta(40) than MCI-MCI or NL-NL. Baseline P-tau(231) best predicted MCI-AD (80%, p Conclusions P-tau(231) is the strongest predictor of the decline from MCI to AD. IP levels uniquely show longitudinal progression effects. These results suggest the use of CSF biomarkers in secondary prevention trials.
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APA 7th
Brys, M., Pirraglia, E., Rich, K., Rolstad, S., Mosconi, L., Switalski, R., et al. (2009). Prediction and longitudinal study of CSF biomarkers in mild cognitive impairment. Neurobiology of aging. https://doi.org/10.1016/j.neurobiolaging.2007.08.010
Vancouver
Brys M, Pirraglia E, Rich K, Rolstad S, Mosconi L, Switalski R, et al. Prediction and longitudinal study of CSF biomarkers in mild cognitive impairment. Neurobiology of aging. 2009. doi:10.1016/j.neurobiolaging.2007.08.010. PMID: 17889968.
BibTeX
@article{brys2009-17889968,
author = {Brys, M. and Pirraglia, E. and Rich, K. and Rolstad, S. and Mosconi, L. and Switalski, R. and Glodzik-Sobanska, L. and De Santi, S. and others},
title = {{Prediction and longitudinal study of CSF biomarkers in mild cognitive impairment}},
journal = {Neurobiology of aging},
year = {2009},
doi = {10.1016/j.neurobiolaging.2007.08.010},
pmid = {17889968},
url = {https://doi.org/10.1016/j.neurobiolaging.2007.08.010}
}
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Key findings
- Results At baseline and at follow-up MCI-AD showed higher levels P-tau(231), T-tau, IP, P-tau(231)/Abeta(42/40) and T-tau/Abeta(42/40) ratios and lower Abeta(42)/Abeta(40) than MCI-MCI or NL-NL.
- These results suggest the use of CSF biomarkers in secondary prevention trials.
Why it matters
This longitudinal study measured five cerebrospinal fluid biomarkers in people with mild cognitive impairment over two years. It found that P-tau(231) was the strongest predictor of decline from mild cognitive impairment to Alzheimer's disease, and the authors suggest these biomarkers could be used in prevention trials.
Study details
- Study designlongitudinal study
- Participants86
- Evidence strengthModerate
How this study scored 58/100
Published in a peer-reviewed journal, and it is a longitudinal study following the same people over time. Scored zero for effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 37 of the 64 points we could judge it on, which is 58 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Neurobiology of aging) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 7 / 12 | A longitudinal study following the same people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2009 — within 20 year(s) of the newest study here |
| Sample size | 1 / 4 | 86 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (OpenAlex dates this DOI to 2007, the record says 2009; OpenAlex values not used) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | 3 / 6 | Cited by 16 other studies in this library |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 17889968) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 37 / 64 | Scored on 12 of 20 parts. We have no data for the rest, so they are left out: 37 of the 64 points we could judge it on is 58 out of 100. |
| Total | 58 / 100 | — |
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