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Hippocampal activation in adults with mild cognitive impairment predicts subsequent cognitive decline
Miller SL, Fenstermacher E, Bates J, Blacker D, Sperling RA, Dickerson BC.. Journal of neurology, neurosurgery, and psychiatry, 2007-09-10
Topic: Risk, prevention and care in population studies
Objective To use functional MRI (fMRI) to investigate whether hippocampal activation during a memory task can predict cognitive decline in individuals with mild cognitive impairment (MCI). Methods 25 older individuals with MCI performed a visual scene encoding task during fMRI scanning, and were followed clinically for at least 4 years after scanning. A hypothesis driven analysis of fMRI data was performed.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Miller, S. L., Fenstermacher, E., Bates, J., Blacker, D., Sperling, R. A., & Dickerson, B. C. (2008). Hippocampal activation in adults with mild cognitive impairment predicts subsequent cognitive decline. Journal of neurology, neurosurgery, and psychiatry. https://doi.org/10.1136/jnnp.2007.124149
Vancouver
Miller SL, Fenstermacher E, Bates J, Blacker D, Sperling RA, Dickerson BC. Hippocampal activation in adults with mild cognitive impairment predicts subsequent cognitive decline. Journal of neurology, neurosurgery, and psychiatry. 2008. doi:10.1136/jnnp.2007.124149. PMID: 17846109.
BibTeX
@article{miller2008-17846109,
author = {Miller, S. L. and Fenstermacher, E. and Bates, J. and Blacker, D. and Sperling, R. A. and Dickerson, B. C.},
title = {{Hippocampal activation in adults with mild cognitive impairment predicts subsequent cognitive decline}},
journal = {Journal of neurology, neurosurgery, and psychiatry},
year = {2008},
doi = {10.1136/jnnp.2007.124149},
pmid = {17846109},
url = {https://doi.org/10.1136/jnnp.2007.124149}
}
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Key findings
- Methods 25 older individuals with MCI performed a visual scene encoding task during fMRI scanning, and were followed clinically for at least 4 years after scanning.
- A hypothesis driven analysis of fMRI data was performed.
- First, fMRI data were analysed at the group level to identify the regions of the hippocampal formation that were engaged by this memory task.
- Parameter estimates of each subject's memory related hippocampal activation (% signal change) were extracted and were analysed with a linear regression model to determine whether hippocampal activation predicted the degree or rate of cognitive decline, as measured by change in Clinical Dementia Rating Sum-of-Boxes (CDR-SB).
Why it matters
In 25 people with mild cognitive impairment, higher activity in the hippocampus during a memory task predicted later cognitive decline over at least four years. This is an early finding from a small group and does not show any treatment or way to prevent decline.
Study details
- Evidence strengthLow
How this study scored 47/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of neurology, neurosurgery, and psychiatry) |
| Journal's citation record | 3 / 4 | Journal of Neurology Neurosurgery & Psychiatry: journal h-index 336 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2008 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 242 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 12.1 citations a year over 20 year(s) since 2008 |
| Impact for its field and year | 3 / 6 | Cited 7.8× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 3 / 6 | Cited by 11 other studies in this library |
| Still being cited | 2 / 4 | Cited 25 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Brad C. Dickerson: h-index 27 (OpenAlex, whole career) |
| Institution's track record | 3 / 3 | Harvard University: institution h-index 3,235 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 4 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 17846109) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 47 / 100 | — |
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