Newest studies

Donepezil preserves cognition and global function in patients with severe Alzheimer disease

72/100 ✓ Peer-reviewed Treatments Neurology

Key finding: Patients with severe AD demonstrated greater efficacy compared to placebo on measures of cognition and global function. +2 more findings

• Treatments
• Clinical Trials

Full summary, score breakdown and related studies → Original source

Does NSAID use modify cognitive trajectories in the elderly? The Cache County study

53/100 ✓ Peer-reviewed Genetics Neurology

Key finding: Nonsteroidal anti-inflammatory drug use may help to prevent cognitive decline in older adults if started in midlife rather than late life. +1 more finding

• Genetics

Full summary, score breakdown and related studies → Original source

Voxel-based morphometry to detect brain atrophy in progressive mild cognitive impairment

48/100 ✓ Peer-reviewed Mild cognitive impairment NeuroImage

Key finding: Recent research has shown an increased rate of conversion to dementia in subjects with mild cognitive impairment (MCI) compared to controls. +4 more findings

• Early Stage
• Brain Scans

Full summary, score breakdown and related studies → Original source

Japanese version of the Frontal Assessment Battery for dementia

41/100 ✓ Peer-reviewed Cognitive tests and assessment Psychiatry research

Key finding: The purpose of this study was to evaluate the validity and reliability of a Japanese version of the FAB to measure cognitive dysfunction in patients with dementia. +3 more findings

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Relation of cognitive activity to risk of developing Alzheimer disease

57/100 ✓ Peer-reviewed Caregiving Neurology

Key finding: Level of cognitively stimulating activity in old age is related to risk of developing dementia. +3 more findings

• Risk Factors
• Brain Biology

Full summary, score breakdown and related studies → Original source

Cannabidiol in vivo blunts beta-amyloid induced neuroinflammation by suppressing IL-1beta and iNOS expression

36/100 ✓ Peer-reviewed Biomarkers British journal of pharmacology

Key finding: The results of the present study confirm in vivo anti-inflammatory actions of CBD, emphasizing the importance of this compound as a novel promising pharmacological tool capable of attenuating Abeta evoked neuroinflammatory responses. +1 more finding

• Brain Biology

Full summary, score breakdown and related studies → Original source

Symmetric diffeomorphic image registration with cross-correlation: evaluating automated labeling of elderly and neurodegenerative brain

61/100 ✓ Peer-reviewed Lewy body dementia Medical image analysis

Key finding: This study indicates that SyN, with cross-correlation, is a reliable method for normalizing and making anatomical measurements in volumetric MRI of patients and at-risk elderly individuals.

Full summary, score breakdown and related studies → Original source

Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar Degeneration

59/100 ✓ Peer-reviewed Getting a diagnosis Acta neuropathologica

Key finding: Molecular genetic studies of familial cases of FTLD-U have shown that mutations in the progranulin (PGRN) gene are a major genetic cause of FTLD-U. +2 more findings

• Diagnosis
• Brain Biology
• Genetics

Full summary, score breakdown and related studies → Original source

Higher frequency of regulatory T cells in the elderly and increased suppressive activity in neurodegeneration

40/100 ✓ Peer-reviewed Inflammation and the immune system Journal of neuroimmunology

Key finding: However, their alteration during ageing and age-related diseases has not been thoroughly investigated yet. +3 more findings

• Brain Biology
• Policy

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Changes in cerebral blood volume and amyloid pathology in aged Alzheimer APP/PS1 mice on a docosahexaenoic acid (DHA) diet or cholesterol enriched Typical Western Diet (TWD)

44/100 ✓ Peer-reviewed Brain scans and imaging Neurobiology of disease

Key finding: The TWD diet increased plaque burden in the dentate gyrus of the hippocampus, but did not significantly reduce rCBV. +1 more finding

• Brain Biology
• Risk Factors
• Lifestyle

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Oxysterols, cholesterol homeostasis, and Alzheimer disease

45/100 ✓ Peer-reviewed Genetics Journal of neurochemistry

Key finding: Oxysterol-mediated LXR activation induces local apoE biosynthesis (predominantly in astrocytes) further enhancing cholesterol re-distribution and removal. +4 more findings

• Genetics
• Brain Biology
• Risk Factors

Full summary, score breakdown and related studies → Original source

Frontotemporal lobar degeneration: clinical and pathological relationships

49/100 ✓ Peer-reviewed Brain tissue and pathology Acta neuropathologica

Key finding: Clinical phenotype is often assumed to be a poor predictor of underlying histopathology. +3 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

Smoking as a risk factor for dementia and cognitive decline: a meta-analysis of prospective studies

70/100 ✓ Peer-reviewed Risk factors American journal of epidemiology

Key finding: Compared with those who never smoked, current smokers at baseline also showed greater yearly declines in Mini-Mental State Examination scores over the follow-up period (effect size (beta)=-0.13, 95% CI: -0.18, -0.08). +2 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Roles of amyloid beta-peptide-associated oxidative stress and brain protein modifications in the pathogenesis of Alzheimer's disease and mild cognitive impairment

36/100 ✓ Peer-reviewed Genetics Free radical biology & medicine

Key finding: Oxidative stress has been implicated to play a crucial role in the pathogenesis of a number of diseases, including neurodegenerative disorders, cancer, and ischemia, just to name a few. +4 more findings

• Brain Biology
• Early Stage

Full summary, score breakdown and related studies → Original source

Mixed brain pathologies account for most dementia cases in community-dwelling older persons

73/100 ✓ Peer-reviewed Getting a diagnosis Neurology

Key finding: The majority of community-dwelling older persons have brain pathology. +1 more finding

• Other Dementias

Full summary, score breakdown and related studies → Original source

Frailty is associated with incident Alzheimer's disease and cognitive decline in the elderly

60/100 ✓ Peer-reviewed Long-term cohort studies Psychosomatic medicine

Key finding: Increasing frailty is associated with incident AD and the rate of cognitive decline in older persons. +4 more findings

• Risk Factors

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{gamma}-Secretase Substrate Concentration Modulates the Abeta42/Abeta40 Ratio: IMPLICATIONS FOR ALZHEIMER DISEASE

43/100 ✓ Peer-reviewed Risk genes beyond APOE The Journal of biological chemistry

Key finding: These mutations lead to an increased Abeta42/Abeta40 ratio that correlates with the onset of disease. +3 more findings

• Genetics

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Rodent A beta modulates the solubility and distribution of amyloid deposits in transgenic mice

45/100 ✓ Peer-reviewed Risk genes beyond APOE The Journal of biological chemistry

Key finding: Three amino acid substitutions distinguish mouse and human A beta that might contribute to their differing properties in vivo. +3 more findings

• Brain Biology

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Expression of APP pathway mRNAs and proteins in Alzheimer's disease

36/100 ✓ Peer-reviewed Biomarkers Brain research

Key finding: We hypothesized that sporadic AD may also be associated with changes in transcription of APP or its metabolic partners. +1 more finding

• Genetics
• Digital Tools

Full summary, score breakdown and related studies → Original source

Forecasting the global burden of Alzheimer's disease

59/100 ✓ Peer-reviewed How common it is Alzheimer s & Dementia

Key finding: In 2006, the worldwide prevalence of Alzheimer's disease was 26.6 million. +4 more findings

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Accelerating amyloid-beta fibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models

50/100 ✓ Peer-reviewed Risk genes beyond APOE The Journal of biological chemistry

Key finding: For most, it is unclear whether shifts from one state to another would be helpful or harmful. +3 more findings

• Brain Biology

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Atypical antipsychotics for the treatment of dementia-related behaviors: an update

38/100 ✓ Peer-reviewed Treatments Medicine and health, Rhode Island

Key finding: The evidence base, although incomplete, suggests that modest treatment effect sizes are offset by risk of considerable adverse effects. +4 more findings

• Treatments
• Side Effects

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Diagnostic criteria for psychosis in Parkinson's disease: report of an NINDS, NIMH work group

36/100 ✓ Peer-reviewed Health systems and care delivery Movement disorders : official journal of the Movement Disorder Society

Key finding: There are no standardized diagnostic criteria for psychosis associated with Parkinson's disease (PDPsy). +3 more findings

• Diagnosis
• Other Dementias
• Treatments

Full summary, score breakdown and related studies → Original source

NMDA receptor trafficking in synaptic plasticity and neuropsychiatric disorders

36/100 ✓ Peer-reviewed Disease mechanisms Nature reviews. Neuroscience

Key finding: The number and subunit composition of synaptic N-methyl-D-aspartate receptors (NMDARs) are not static, but change in a cell- and synapse-specific manner during development and in response to neuronal activity and sensory experience. +2 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

A genomic pathway approach to a complex disease: axon guidance and Parkinson disease

40/100 ✓ Peer-reviewed Prevention and risk PLoS genetics

Key finding: These findings could have important implications regarding the pathogenesis of PD.

• Genetics
• Other Dementias

Full summary, score breakdown and related studies → Original source