Home › Research › Lewy body dementia
Blood-brain barrier: ageing and microvascular disease--systematic review and meta-analysis
Farrall AJ, Wardlaw JM.. Neurobiology of aging, 2007-09-14
Topic: Risk, prevention and care in population studies
Cerebral "microvascular" disease occurs in lacunar stroke, leukoaraiosis, vascular dementia and Alzheimer's disease. It may arise from or contribute to insidious damage to the blood-brain barrier (BBB). We systematically reviewed the literature for evidence that BBB permeability is altered in patients with manifestations of cerebral microvascular disease. We found 31 BBB permeability studies (1953 individuals) of normal ageing or cerebral microvascular disease. In healthy humans, increasing age (10 comparisons, controls(C):subjects(S)=357:336) was associated with increased BBB permeability (standardised mean difference (S.M.D.) 1.21, 95% confidence interval (CI) 0.60, 1.81, p<0.01). BBB permeability was increased further in patients with either vascular or Alzheimer's dementia compared with age-matched controls (26 comparisons, C:S=510:547, S.M.D. 0.81, 99% CI 0.37, 1.26, p<0.01); in vascular compared with Alzheimer's dementia (10 comparisons, C:S=291:165, S.M.D. 0.71, 99% CI 0.12, 1.29, p<0.01); and with worsening leukoaraiosis (5 comparisons, C:S=122:88, S.M.D. 0.60, 99% CI 0.30, 0.89, p<0.01). BBB permeability increases with normal ageing and may be an important mechanism in the initiation or worsening of cerebral microvascular disease. Further studies on the role of BBB permeability are urgently needed.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Farrall, A. J., & Wardlaw, J. M. (2009). Blood-brain barrier: ageing and microvascular disease--systematic review and meta-analysis. Neurobiology of aging. https://doi.org/10.1016/j.neurobiolaging.2007.07.015
Vancouver
Farrall AJ, Wardlaw JM. Blood-brain barrier: ageing and microvascular disease--systematic review and meta-analysis. Neurobiology of aging. 2009. doi:10.1016/j.neurobiolaging.2007.07.015. PMID: 17869382.
BibTeX
@article{farrall2009-17869382,
author = {Farrall, A. J. and Wardlaw, J. M.},
title = {{Blood-brain barrier: ageing and microvascular disease--systematic review and meta-analysis}},
journal = {Neurobiology of aging},
year = {2009},
doi = {10.1016/j.neurobiolaging.2007.07.015},
pmid = {17869382},
url = {https://doi.org/10.1016/j.neurobiolaging.2007.07.015}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- We found 31 BBB permeability studies (1953 individuals) of normal ageing or cerebral microvascular disease.
- In healthy humans, increasing age (10 comparisons, controls(C):subjects(S)=357:336) was associated with increased BBB permeability (standardised mean difference (S.M.D.) 1.21, 95% confidence interval (CI) 0.60, 1.81, p<0.01).
- BBB permeability was increased further in patients with either vascular or Alzheimer's dementia compared with age-matched controls (26 comparisons, C:S=510:547, S.M.D. 0.81, 99% CI 0.37, 1.26, p<0.01); in vascular compared with Alzheimer's dementia (10 comparisons, C:S=291:165, S.M.D. 0.71, 99% CI 0.12, 1.29, p<0.01); and with worsening leukoaraiosis (5 comparisons, C:S=122:88, S.M.D. 0.60, 99% CI 0.30, 0.89, p<0.01).
Why it matters
This systematic review and meta-analysis found that the blood-brain barrier becomes more permeable with normal ageing and even more so in people with vascular or Alzheimer's dementia. It suggests that increased blood-brain barrier permeability may be an important mechanism in the beginning or worsening of cerebral microvascular disease, but further studies are needed and no treatment is tested.
Study details
- Participants1,953
- Evidence strengthLow
How this study scored 66/100
Published in a peer-reviewed journal, and it is a meta-analysis pooling many studies. Scored zero for effect reported because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 42 of the 64 points we could judge it on, which is 66 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Neurobiology of aging) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 12 / 12 | A meta-analysis pooling many studies (from PubMed type “Meta-Analysis”) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2009 — within 20 year(s) of the newest study here |
| Sample size | 3 / 4 | 1,953 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | A review of other studies — randomisation is not credited here |
| Times cited | — / 7 | No citation count (OpenAlex dates this DOI to 2007, the record says 2009; OpenAlex values not used) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | 3 / 6 | Cited by 18 other studies in this library |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 17869382) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 42 / 64 | Scored on 12 of 20 parts. We have no data for the rest, so they are left out: 42 of the 64 points we could judge it on is 66 out of 100. |
| Total | 66 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
Free copy unknown: no free-copy check has an answer for this record yet. That does not mean it is paywalled.
Studies this one cites
Referenced by this study and also in the alzhub library, so you can read them here.
Later studies that cite this one
18 studies in the alzhub library list this one in their references. Showing the 8 highest-scoring.
Related studies in Lewy body dementia
Also tagged “vessel”
900 studies in the library carry the topic tag “vessel”; these are this study's neighbours in a fixed, alphabetical-by-hash tour of them, not the closest in content. All 900 tagged studies.