alzhub.org
Get help now — free helplines

You can call any of these for free. You do not need a diagnosis, an appointment, or a crisis to call — questions and plain exhaustion are reasons enough.

  • Alzheimer's Association 24/7 Helpline 800-272-3900 24 hours a day, 365 days a year Free, confidential support and information for people with dementia, caregivers, families and the public. Master's-level clinicians. Also Spanish.
  • 988 Suicide & Crisis Lifeline 988 24/7 Call or text 988, or chat at 988lifeline.org. For anyone in emotional distress or a mental-health crisis, including caregivers.
  • Alzheimer's Foundation of America (AFA) Helpline 866-232-8484 9:00 am - 9:00 pm ET, seven days a week Licensed social workers providing support, info and referrals. Also text message and web chat. Text: 646-586-5283

In a medical emergency, call 911. More numbers, and what each line does, on the help page.

Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 23,051–23,075 of 27,380 studies, newest first · page 923 of 1096.

July 2006 25

  1. 2006-07-20

    Extrahippocampal contributions to age differences in human spatial navigation

    ✓ Peer-reviewed Hippocampus size on brain scans Cerebral cortex (New York, N.Y. : 1991)

    Key finding: The hippocampus (HC) and associated neural structures are hypothesized to contribute to individual differences in human spatial navigation. +3 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2006-07-20

    White matter grade and ventricular volume on brain MRI as markers of longevity in the cardiovascular health study

    ✓ Peer-reviewed Disparities Neurobiology of aging

    Key finding: High white matter grade (WMG) on magnetic resonance imaging (MRI) is a risk factor for dementia, stroke and disability. +4 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2006-07-19

    Two-year follow-up of amyloid deposition in patients with Alzheimer's disease

    ✓ Peer-reviewed Brain scans and imaging Brain

    Beta amyloid is one of the major histopathological hallmarks of Alzheimer's disease.

    Full summary, score breakdown and related studies → Original source

  4. 2006-07-17

    Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease

    ✓ Peer-reviewed Lewy body dementia The Journal of biological chemistry

    Key finding: Small amounts of Ser-129 phosphorylated and Asp-119-truncated alpha-synuclein are present in the soluble fraction of both normal and disease brains, suggesting that these Lewy body-associated forms are produced during normal metabolism of alpha-synuclein.

    Full summary, score breakdown and related studies → Original source

  5. 2006-07-16

    Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21

    ✓ Peer-reviewed Lewy body dementia Nature

    Key finding: The finding was made within an extensively documented Belgian FTDU-17 founder family. +4 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2006-07-16

    Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17

    ✓ Peer-reviewed Lewy body dementia Nature

    Key finding: However, in multiple FTD families with significant evidence for linkage to the same region on chromosome 17q21 (D17S1787-D17S806), mutations in MAPT have not been found and the patients consistently lack tau-immunoreactive inclusion pathology. +1 more finding

    Full summary, score breakdown and related studies → Original source

  7. 2006-07-14

    Contribution of presenilin transmembrane domains 6 and 7 to a water-containing cavity in the gamma-secretase complex

    ✓ Peer-reviewed Risk genes beyond APOE The Journal of biological chemistry

    Key finding: Mutations in Presenilin, the catalytic core of this complex, cause Alzheimer disease. +3 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2006-07-12

    Alzheimer's disease beta-amyloid peptides are released in association with exosomes

    ✓ Peer-reviewed Risk genes beyond APOE Proceedings of the National Academy of Sciences of the United States of America

    Key finding: Subsequently, a minute fraction of Abeta peptides can be secreted from the cells in association with exosomes, intraluminal vesicles of MVBs that are released into the extracellular space as a result of fusion of MVBs with the plasma membrane.

    Full summary, score breakdown and related studies → Original source

  9. 2006-07-11

    Magnetoencephalographic evaluation of resting-state functional connectivity in Alzheimer's disease

    ✓ Peer-reviewed Brain scans and imaging NeuroImage

    Key finding: In the alpha1 and beta band, Alzheimer patients showed a loss of long distance intrahemispheric interactions, with a focus on left fronto-temporal/parietal connections. +4 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2006-07-10

    Behavioral effects of memantine in Alzheimer disease patients receiving donepezil treatment

    ✓ Peer-reviewed Treatments Neurology

    Key finding: Patients treated with memantine had significantly lower NPI total scores than patients treated with placebo. +4 more findings

    Full summary, score breakdown and related studies → Original source

  11. 2006-07-08

    The neuronal ceroid-lipofuscinoses: from past to present

    ✓ Peer-reviewed Disparities Biochimica et biophysica acta

    Key finding: Autofluorescent, periodic acid-Schiff- and Sudan black B-positive granules, resistant to lipid solvents, accumulate in the cytoplasm of most nerve cells, and there is progressive and remarkably selective neuronal degeneration and loss. +4 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2006-07-07

    Hippocampal hypocellularity in the Ts65Dn mouse originates early in development

    ✓ Peer-reviewed Hippocampus size on brain scans Brain research

    Key finding: Previous studies have shown that older adult Ts65Dn mice have structural abnormalities in the hippocampus including fewer granule cells in dentate gyrus and more pyramidal cells in the CA3 subfield of cornus ammonis. +1 more finding

    Full summary, score breakdown and related studies → Original source

  13. 2006-07-06

    Blood-brain barrier: structural components and function under physiologic and pathologic conditions

    ✓ Peer-reviewed Inflammation and the immune system Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology

    Key finding: As a result of restricted permeability, the BBB is a limiting factor for the delivery of therapeutic agents into the CNS.

    Full summary, score breakdown and related studies → Original source

  14. 2006-07-05

    Synapse Formation and Function Is Modulated by the Amyloid Precursor Protein

    ✓ Peer-reviewed Disease mechanisms Journal of Neuroscience

    Key finding: Using autaptic cultures of hippocampal neurons, we demonstrate that hippocampal neurons lacking APP show significantly enhanced amplitudes of evoked AMPA- and NMDA-receptor-mediated EPSCs. +3 more findings

    Full summary, score breakdown and related studies → Original source

  15. 2006-07-04

    Neuropsychiatric symptoms in patients with Parkinson's disease and dementia: frequency, profile and associated care giver stress

    ✓ Peer-reviewed Treatments Journal of neurology, neurosurgery, and psychiatry

    Key finding: Neuropsychiatric symptoms are common in patients with PDD. +2 more findings

    Full summary, score breakdown and related studies → Original source

  16. 2006-07-03

    Apolipoprotein E structure: insights into function

    ✓ Peer-reviewed Genetics Trends in biochemical sciences

    Key finding: Human apolipoprotein E (apoE) is a member of the family of soluble apolipoproteins. +3 more findings

    Full summary, score breakdown and related studies → Original source

  17. 2006-07-01

    BACE2, as a novel APP theta-secretase, is not responsible for the pathogenesis of Alzheimer's disease in Down syndrome

    ✓ Peer-reviewed Down syndrome and Alzheimer's FASEB journal : official publication of the Federation of American Societies for Experimental Biology

    Key finding: We and others have shown that APP C99, the major beta-secretase product, and Abeta are markedly increased in DS. +1 more finding

    Full summary, score breakdown and related studies → Original source

  18. 2006-07-01

    Cerebrospinal fluid amyloid beta42/phosphorylated tau ratio discriminates between Alzheimer's disease and vascular dementia

    ✓ Peer-reviewed Biomarkers The journals of gerontology. Series A, Biological sciences and medical sciences

    Key finding: Our results support further efforts to prospectively validate the use of Q Abeta42/p-tau as a biomarker to discriminate between AD and VaD. +1 more finding

    Full summary, score breakdown and related studies → Original source

  19. 2006-07-01

    Advanced dementia research in the nursing home: the CASCADE study

    ✓ Peer-reviewed End-of-life care Alzheimer disease and associated disorders

    Key finding: The demographic features, ownership, staffing, and quality of care of participant facilities are presented and compared to NHs nationwide. +1 more finding

    Full summary, score breakdown and related studies → Original source

  20. 2006-07-01

    The validity and reliability of scales for the evaluation of end-of-life care in advanced dementia

    ✓ Peer-reviewed End-of-life care Alzheimer disease and associated disorders

    Key finding: The scales demonstrated satisfactory to good reliability: SM-EOLD (alpha=0.68), SWC-EOLD (alpha=0.83), and CAD-EOLD (alpha=0.82). +1 more finding

    Full summary, score breakdown and related studies → Original source

  21. 2006-07-01

    Behavioral and psychologic symptoms in different types of dementia

    ✓ Peer-reviewed Clinical safety Journal of the Formosan Medical Association = Taiwan yi zhi

    Key finding: A strategy of targeting type-specific BPSD may be beneficial, such as environmental stimulus control for DLB patients who are prone to have hallucinations, design of a pacing path for patients with FTD who need support for symptoms of wandering and emotional support for patients with VaD who are susceptible to depression.

    Full summary, score breakdown and related studies → Original source

  22. 2006-07-01

    Role of the pro-inflammatory cytokines TNF-alpha and IL-1beta in HIV-associated dementia

    ✓ Peer-reviewed Inflammation and the immune system European journal of clinical investigation

    Key finding: Two of these neurotoxins are the pro-inflammatory cytokines tumour necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta), which are thought to play a major role in inducing neuronal death. +3 more findings

    Full summary, score breakdown and related studies → Original source

  23. 2006-07-01

    Dietary folate, vitamin B12, and vitamin B6 and the risk of Parkinson disease

    ✓ Peer-reviewed Long-term cohort studies Neurology

    Key finding: Increased homocysteine levels might accelerate dopaminergic cell death in Parkinson disease (PD), through neurotoxic effects. +3 more findings

    Full summary, score breakdown and related studies → Original source

  24. 2006-07-01

    Physical and cognitive domains of the Instrumental Activities of Daily Living: validation in a multiethnic population of Asian older adults

    ✓ Peer-reviewed Cognitive tests and assessment The journals of gerontology. Series A, Biological sciences and medical sciences

    Key finding: Factor analyses yielded two strong and reliable factors representing underlying physical and cognitive dimensions of IADL. +3 more findings

    Full summary, score breakdown and related studies → Original source

  25. 2006-07-01

    Mean age-of-onset of familial alzheimer disease caused by presenilin mutations correlates with both increased Abeta42 and decreased Abeta40

    ✓ Peer-reviewed Risk genes beyond APOE Human mutation

    Key finding: Nonetheless, one useful diagnostic marker is an increased ratio of Ab42 to Ab40 (Ab42/Ab40) in patients' brain and biological fluids as well as in transgenic mice and cells. +3 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →