Newest studies

Volumetric MRI and cognitive measures in Alzheimer disease : comparison of markers of progression

59/100 ✓ Peer-reviewed Brain scans and imaging Journal of neurology

Key finding: Rates of brain atrophy and/or ventricular enlargement were correlated with declining performance on cognitive scales. +1 more finding

• Brain Scans
• Clinical Trials
• Diagnosis

Full summary, score breakdown and related studies → Original source

Soluble oligomers of the amyloid beta-protein impair synaptic plasticity and behavior

36/100 ✓ Peer-reviewed Brain tissue and pathology Behavioural brain research

Key finding: We find that these naturally secreted soluble oligomers--at picomolar concentrations--can disrupt hippocampal LTP in slices and in vivo and can also impair the memory of a complex learned behavior in rats. +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Grocery lists: connecting family, household and grocery store

37/100 ✓ Peer-reviewed Risk factors British Food Journal

Key finding: Most family members contributed to a grocery list. +4 more findings

• Caregiving

Full summary, score breakdown and related studies → Original source

Expression of Osteoarthritis Marker YKL-39 is Stimulated by Transforming Growth Factor Beta (TGF-beta) and IL-4 in Differentiating Macrophages

34/100 ✓ Peer-reviewed Tau biomarkers Biomarker insights

Key finding: YKL-39 was identified as an abundantly secreted protein in primary culture of human articular chondrocytes. +3 more findings

Full summary, score breakdown and related studies → Original source

Prevalence and impact of vascular and Alzheimer pathologies in Lewy body disease

54/100 ✓ Peer-reviewed Genetics Acta neuropathologica

Key finding: A retrospective clinico-pathologic study of 100 patients with autopsy proven PD (including 44 cases with dementia/PDD) and 20 cases of dementia with Lewy bodies (DLB) confirmed essential clinical (duration of illness, Mini-Mental State Examination/MMSE, age at death) and morphologic differences between these groups; Lewy body Braak scores and Alzheimer pathologies (neuritic Braak stage, cortical Abeta plaque load, and generalized cerebral amyloid angiopathy or CAA) were significantly higher/more severe in DLB and PDD than in PD without dementia. +3 more findings

• Other Dementias
• Genetics

Full summary, score breakdown and related studies → Original source

Adaptor protein sorting nexin 17 regulates amyloid precursor protein trafficking and processing in the early endosomes

46/100 ✓ Peer-reviewed Risk genes beyond APOE The Journal of biological chemistry

Key finding: Production of Abeta from APP is greatly affected by the subcellular localization and trafficking of APP. +3 more findings

Full summary, score breakdown and related studies → Original source

Patients dying with dementia: experience at the end of life and impact of hospice care

50/100 ✓ Peer-reviewed End-of-life care Journal of pain and symptom management

Key finding: Patients who were enrolled in hospice were significantly more likely to die in their location of choice (odds ratio [OR] 9.67; 95% confidence interval [CI] 2.57-37.0), and less likely to die in the hospital, (OR 0.04; 95% CI 0.01-0.18), compared to nonenrollees. +4 more findings

• End-of-Life Care

Full summary, score breakdown and related studies → Original source

NFkappaB-dependent control of BACE1 promoter transactivation by Abeta42

46/100 ✓ Peer-reviewed Risk genes beyond APOE The Journal of biological chemistry

Key finding: Very few data document a putative cross-talk between these proteases and the regulatory mechanisms underlying such interaction. +3 more findings

Full summary, score breakdown and related studies → Original source

Apolipoprotein E epsilon4 magnifies lifestyle risks for dementia: a population-based study

58/100 ✓ Peer-reviewed Prevention and risk Journal of cellular and molecular medicine

Key finding: The risk of dementia and Alzheimer's disease (AD) probably results from an interaction between genetic and environmental factors. +2 more findings

• Genetics
• Lifestyle
• Risk Factors

Full summary, score breakdown and related studies → Original source

11C PiB and structural MRI provide complementary information in imaging of Alzheimer's disease and amnestic mild cognitive impairment

60/100 ✓ Peer-reviewed Brain scans and imaging Brain

Key finding: Interestingly, we found no consistent differences in learning and memory performance between high versus low PiB cognitively normal or amnestic MCI subjects. +4 more findings

• Brain Scans
• Early Stage
• Brain Biology

Full summary, score breakdown and related studies → Original source

The Mayo Clinic Study of Aging: design and sampling, participation, baseline measures and sample characteristics

58/100 ✓ Peer-reviewed Getting a diagnosis Neuroepidemiology

Key finding: Strengths of the study are that the subjects were randomly selected from a defined population, the majority of the subjects were examined in person, and MCI was defined using published criteria.

Full summary, score breakdown and related studies → Original source

Use of antihypertensives and the risk of Parkinson disease

53/100 ✓ Peer-reviewed Drug development Neurology

Key finding: Current long-term use of calcium channel blockers was associated with a significantly reduced risk of a Parkinson disease diagnosis, while the risk was not materially altered for users of angiotensin converting enzyme inhibitors or beta-blockers and, with less statistical precision, for users of angiotensin II antagonists. +2 more findings

• Other Dementias
• Risk Factors

Full summary, score breakdown and related studies → Original source

Six-Month Randomized, Placebo-Controlled, Double-Blind, Pilot Clinical Trial of Curcumin in Patients With Alzheimer Disease

40/100 ✓ Peer-reviewed Clinical trials Journal of Clinical Psychopharmacology

Key finding: Baum, Larry PhD; Lam, Christopher Wai Kei PhD; Cheung, Stanley Kwok-Kuen MSc; Kwok, Timothy MD; Lui, Victor MRCPsych; Tsoh, Joshua MRCPsych; Lam, Linda MD, MRCPsych; Leung, Vivian FHKCPsy; Hui, Elsie FRCP; Ng, Chelsia HBSc; Woo, Jean MD; Chiu, Helen Fung Kum FRCPsych; Goggins, William B. +1 more finding

• Clinical Trials

Full summary, score breakdown and related studies → Original source

Cerebral amyloid angiopathy: pathogenetic mechanisms and link to dense amyloid plaques

38/100 ✓ Peer-reviewed Biomarkers Genes, brain, and behavior

Key finding: A review of factors involved in CAA caused by wild-type Abeta suggests that increased Abeta levels in brain without an increased Abeta42/Abeta40 ratio is one of the most important prerequisites for vascular amyloidosis. +1 more finding

• Brain Biology
• Genetics

Full summary, score breakdown and related studies → Original source

Patterns of antimicrobial use among nursing home residents with advanced dementia

43/100 ✓ Peer-reviewed End-of-life care Archives of internal medicine

Key finding: Persons with advanced dementia are frequently exposed to antimicrobials, especially during the 2 weeks before death. +1 more finding

• Care Services

Full summary, score breakdown and related studies → Original source

Mechanisms and functional implications of adult neurogenesis

36/100 ✓ Peer-reviewed Risk factors Cell

Key finding: The generation of new neurons is sustained throughout adulthood in the mammalian brain due to the proliferation and differentiation of adult neural stem cells. +2 more findings

Full summary, score breakdown and related studies → Original source

Carbonic anhydrases: novel therapeutic applications for inhibitors and activators

36/100 ✓ Peer-reviewed Risk factors Nature reviews. Drug discovery

Key finding: Furthermore, recent studies suggest that CA activation may provide a novel therapy for Alzheimer's disease.

• Treatments

Full summary, score breakdown and related studies → Original source

Long-term air pollution exposure is associated with neuroinflammation, an altered innate immune response, disruption of the blood-brain barrier, ultrafine particulate deposition, and accumulation of amyloid beta-42 and alpha-synuclein in children and young adults

47/100 ✓ Peer-reviewed Genetics Toxicologic pathology

Key finding: We investigated whether residency in cities with high air pollution is associated with neuroinflammation/neurodegeneration in healthy children and young adults who died suddenly. +1 more finding

• Brain Biology
• Genetics
• Risk Factors

Full summary, score breakdown and related studies → Original source

Hospice effect on government expenditures among nursing home residents

62/100 ✓ Peer-reviewed End-of-life care Health services research

Key finding: Hospice enrollment results in lower combined Medicare/Medicaid expenditures in the last month of life, particularly among short-stay NH residents. +2 more findings

• End-of-Life Care
• Policy
• Care Services

Full summary, score breakdown and related studies → Original source

Practice parameter: Assessing patients in a neurology practice for risk of falls (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology

40/100 ✓ Peer-reviewed Clinical safety Neurology

Key finding: Patients with neurologic or general conditions associated with an increased risk of falling should be asked about recent falls and further examined for the presence of specific neurologic deficits that predict falls, which include gait and balance disorders; deficits of lower extremity strength, sensation, and coordination; and cognitive impairments. +1 more finding

Full summary, score breakdown and related studies → Original source

Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease

67/100 ✓ Peer-reviewed Inflammation and the immune system Nature

Key finding: A fundamental tenet of the amyloid hypothesis of Alzheimer's disease is that the deposition of amyloid-beta precedes and induces the neuronal abnormalities that underlie dementia. +3 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Omega-3 supplementation in mild to moderate Alzheimer's disease: effects on neuropsychiatric symptoms

65/100 ✓ Peer-reviewed Cognitive tests and assessment International journal of geriatric psychiatry

Key finding: Epidemiological and animal studies have suggested that dietary fish or fish oil rich in omega-3 fatty acids (omega3), docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), may have effects in psychiatric and behavioral symptoms in Alzheimer's disease (AD). +3 more findings

• Lifestyle

Full summary, score breakdown and related studies → Original source

Peripheral levels of glutathione and protein oxidation as markers in the development of Alzheimer's disease from Mild Cognitive Impairment

45/100 ✓ Peer-reviewed Mild cognitive impairment Free radical research

Key finding: The results showed an increase in protein modification, a decrease in GSH levels and GSH/GSSG ratio in AD and MCI patients compared to age-matched control subjects (p<0.05). +1 more finding

• Early Stage

Full summary, score breakdown and related studies → Original source

Diffusion tensor imaging in mild cognitive impairment and Alzheimer's disease: a review

44/100 ✓ Peer-reviewed Mild cognitive impairment Current opinion in neurology

Key finding: Recent findings Mild cognitive impairment represents a transition phase between normal ageing and early Alzheimer's disease. +4 more findings

• Brain Scans
• Early Stage

Full summary, score breakdown and related studies → Original source

Frontal paralimbic network atrophy in very mild behavioral variant frontotemporal dementia

63/100 ✓ Peer-reviewed How common it is Archives of neurology

Key finding: Very mild bvFTD targets a specific subset of frontal and insular regions. +1 more finding

• Other Dementias

Full summary, score breakdown and related studies → Original source