alzhub.org
Get help now — free helplines

You can call any of these for free. You do not need a diagnosis, an appointment, or a crisis to call — questions and plain exhaustion are reasons enough.

  • Alzheimer's Association 24/7 Helpline 800-272-3900 24 hours a day, 365 days a year Free, confidential support and information for people with dementia, caregivers, families and the public. Master's-level clinicians. Also Spanish.
  • 988 Suicide & Crisis Lifeline 988 24/7 Call or text 988, or chat at 988lifeline.org. For anyone in emotional distress or a mental-health crisis, including caregivers.
  • Alzheimer's Foundation of America (AFA) Helpline 866-232-8484 9:00 am - 9:00 pm ET, seven days a week Licensed social workers providing support, info and referrals. Also text message and web chat. Text: 646-586-5283

In a medical emergency, call 911. More numbers, and what each line does, on the help page.

Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 9,701–9,725 of 27,380 studies, newest first · page 389 of 1096.

October 2021 25

  1. 2021-10-14

    Cognitive reserve proxies, Alzheimer pathologies, and cognition

    ✓ Peer-reviewed Risk factors Neurobiology of aging

    Key finding: For overall participants, only education moderated the relationship between Aβ deposition and cognition. +1 more finding

    Full summary, score breakdown and related studies → Original source

  2. 2021-10-14

    CD4 + T cells contribute to neurodegeneration in Lewy body dementia

    ✓ Peer-reviewed Genetics Science (New York, N.Y.)

    Key finding: Recent studies indicate that the adaptive immune system plays a role in Lewy body dementia (LBD). +3 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2021-10-14

    Use of Post-Acute Care by Medicare Beneficiaries With a Diagnosis of Dementia

    ✓ Peer-reviewed Health systems and care delivery Journal of the American Medical Directors Association

    Key finding: We calculated overall utilization and trends in post-acute care use over time, stratified by dementia diagnosis, type of post-acute care (SNF vs HH), and payer (fee-for-service vs Medicare Advantage). +2 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2021-10-14

    A review on omics-based biomarkers discovery for Alzheimer's disease from the bioinformatics perspectives: Statistical approach vs machine learning approach

    ✓ Peer-reviewed Digital health tools Computers in biology and medicine

    Key finding: Omics techniques, including genomics, transcriptomics, proteomics and metabolomics, may reveal the pathways that lead to neuronal death and identify biomolecular markers associated with AD. +1 more finding

    Full summary, score breakdown and related studies → Original source

  5. 2021-10-13

    How Can Cognitive Reserve Promote Cognitive and Neurobehavioral Health?

    ✓ Peer-reviewed Risk factors Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists

    Key finding: Evidence supports the concept of reserve, which can be influenced by experiences in every stage of life. +1 more finding

    Full summary, score breakdown and related studies → Original source

  6. 2021-10-13

    Multi-label, multi-domain learning identifies compounding effects of HIV and cognitive impairment

    ✓ Peer-reviewed Prevention trials Medical image analysis

    Key finding: Based on cross-validation on the UCSF dataset, the multi-domain and multi-label learning strategy leads to superior classification accuracy compared with one-domain or multi-class learning approaches, specifically for the undersampled HIV-only cohort.

    Full summary, score breakdown and related studies → Original source

  7. 2021-10-13

    Health-economic burden of dementia in South Korea

    ✓ Peer-reviewed Digital health tools BMC geriatrics

    Key finding: The burden of dementia in Korea is expected to considerably increase alongside the elderly population in the future.

    Full summary, score breakdown and related studies → Original source

  8. 2021-10-13

    Cerebrospinal fluid markers for synaptic function and Alzheimer type changes in late life depression

    ✓ Peer-reviewed Tau biomarkers Scientific reports

    Key finding: A cross-sectional study to compare cerebrospinal fluid (CSF) levels of neurogranin (Ng), Beta-site amyloid-precursor-protein cleaving enzyme1 (BACE1), Ng/BACE1 ratio and Amyloid-β 42/40 ratio, phosphorylated-tau and total-tau in LLD with (LLD AD) or without (LLD NoAD) AD pathology, predementia AD and normal controls (NC). +3 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2021-10-13

    Microglial activation states drive glucose uptake and FDG-PET alterations in neurodegenerative diseases

    ✓ Peer-reviewed TREM2 and immune genetics Science translational medicine

    Key finding: Here, we investigated whether the FDG-PET signal is directly influenced by microglial glucose uptake in mouse models and patients with neurodegenerative diseases. +3 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2021-10-12

    A Primer on the Evolution of Aducanumab: The First Antibody Approved for Treatment of Alzheimer’s Disease

    ✓ Peer-reviewed Treatments Journal of Alzheimer's Disease

    Key finding: It incurs significant biopsychosocial burden worldwide with limited treatment options.

    Full summary, score breakdown and related studies → Original source

  11. 2021-10-12

    Genome-wide association study of idiopathic hypersomnia in a Japanese population

    ✓ Peer-reviewed Genetics Sleep and biological rhythms

    Key finding: Narcolepsy type 1 is strongly associated with human leukocyte antigen (HLA)-DQB1*06:02; however, no significant associations between IH and HLA alleles have been reported. +3 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2021-10-12

    Prevalence, Risk Factors, and Impact of Delirium on Hospitalized Older Adults With Dementia: A Systematic Review and Meta-Analysis

    ✓ Peer-reviewed Clinical safety Journal of the American Medical Directors Association

    Key finding: These findings suggested high prevalence and detrimental impact of DSD in hospitalized older adults, highlighting a need for early identification, prevention, and treatments. +2 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2021-10-12

    Diffusion Tensor MRI Structural Connectivity and PET Amyloid Burden in Preclinical Autosomal Dominant Alzheimer Disease: The DIAN Cohort

    ✓ Peer-reviewed Biomarkers Radiology

    Key finding: White matter structural connectivity was lower in autosomal dominant Alzheimer disease mutation carriers compared with noncarriers and correlated with estimated years to symptom onset. +4 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2021-10-11

    Microbiota-Gut-Brain Axis and Epilepsy: A Review on Mechanisms and Potential Therapeutics

    ✓ Peer-reviewed Disease mechanisms Frontiers in immunology

    Key finding: Epilepsy is a complex disease with multiple risk factors that affect more than 50 million people worldwide; nearly 30% of patients with epilepsy cannot be controlled with drugs. +4 more findings

    Full summary, score breakdown and related studies → Original source

  15. 2021-10-11

    Experimental and real-world evidence supporting the computational repurposing of bumetanide for APOE4 -related Alzheimer's disease

    ✓ Peer-reviewed Digital health tools Nature aging

    Key finding: Single-nucleus RNA-sequencing revealed transcriptomic reversal of AD signatures in specific cell types in these mice, a finding confirmed in apoE4-iPSC-derived neurons. +1 more finding

    Full summary, score breakdown and related studies → Original source

  16. 2021-10-11

    Multidomain interventions: state-of-the-art and future directions for protocols to implement precision dementia risk reduction. A user manual for Brain Health Services-part 4 of 6

    ✓ Peer-reviewed Prevention trials Alzheimer's research & therapy

    Key finding: Multidomain intervention studies conducted so far appear to have mixed results and substantial variability in target populations, format and intensity of interventions, choice of control conditions, and outcome measures. +1 more finding

    Full summary, score breakdown and related studies → Original source

  17. 2021-10-11

    Quality of Care and Outcomes Among a Diverse Group of Long-Term Care Residents With Alzheimer’s Disease and Related Dementias

    ✓ Peer-reviewed Health systems and care delivery Journal of Aging and Health

    Key finding: In 2016, there were 1,005,781 Medicare Advantage and fee-for-service long-term residents. +4 more findings

    Full summary, score breakdown and related studies → Original source

  18. 2021-10-11

    Neurofilament light chain and α-synuclein RT-QuIC as differential diagnostic biomarkers in parkinsonisms and related syndromes

    ✓ Peer-reviewed Cognitive tests and assessment NPJ Parkinson's disease

    Key finding: We assessed their performance in discriminating Parkinson disease (PD) from atypical parkinsonisms (APDs) and evaluated the association between NfL levels and clinical measures of disease severity. +3 more findings

    Full summary, score breakdown and related studies → Original source

  19. 2021-10-11

    Uncovering Disease Mechanisms in a Novel Mouse Model Expressing Humanized APOEε4 and Trem2*R47H

    ✓ Peer-reviewed TREM2 and immune genetics Frontiers in aging neuroscience

    Key finding: Despite exceptional efforts to understand disease progression via legacy amyloidogenic transgene mouse models, focus on disease translation with innovative mouse strains that better model the complexity of human AD is required to accelerate the development of future treatment modalities. +3 more findings

    Full summary, score breakdown and related studies → Original source

  20. 2021-10-11

    Modifiable risk factors for dementia and dementia risk profiling. A user manual for Brain Health Services-part 2 of 6

    ✓ Peer-reviewed Digital health tools Alzheimer's research & therapy

    Key finding: Rare variants should only be investigated in users with a family history of early-onset dementia in a first degree relative. +4 more findings

    Full summary, score breakdown and related studies → Original source

  21. 2021-10-10

    Oat Extract Avenanthramide-C Reverses Hippocampal Long-Term Potentiation Decline in Tg2576 Mice

    ✓ Peer-reviewed Disease mechanisms Molecules (Basel, Switzerland)

    Key finding: Furthermore, Avn-C-facilitated LTP was associated with changes in the protein levels of phospho-glycogen synthase kinase-3β (p-GSK3β-S9) and cleaved caspase 3, which are involved in Aβ-induced synaptic impairment. +1 more finding

    Full summary, score breakdown and related studies → Original source

  22. 2021-10-10

    Interactions between dietary patterns and genetic factors in relation to incident dementia among 70-year-olds

    ✓ Peer-reviewed Prevention and risk European journal of nutrition

    Key finding: There were interactions between the dietary patterns and APOE ε4 status in relation to incident dementia (interaction p value threshold of < 0.1), while no evidence of interactions were found between the dietary patterns and the AD-PRSs. +3 more findings

    Full summary, score breakdown and related studies → Original source

  23. 2021-10-10

    Alzheimer's Disease, Mild Cognitive Impairment and Mediterranean Diet. A Systematic Review and Dose-Response Meta-Analysis

    ✓ Peer-reviewed Prevention trials Journal of clinical medicine

    Key finding: Higher adherence to MD was associated with a significantly lower risk of MCI (RR = 0.91, 95%CI = 0.85-0.97) and lower risk of AD (RR = 0.89, 95% CI = 0.84-0.93). +1 more finding

    Full summary, score breakdown and related studies → Original source

  24. 2021-10-09

    Cardiometabolic risk factors associated with brain age and accelerate brain ageing

    ✓ Peer-reviewed Digital health tools Human brain mapping

    Key finding: The structure and integrity of the ageing brain is interchangeably linked to physical health, and cardiometabolic risk factors (CMRs) are associated with dementia and other brain disorders. +3 more findings

    Full summary, score breakdown and related studies → Original source

  25. 2021-10-08

    Gender differences in cognitive reserve: implication for subjective cognitive decline in women

    ✓ Peer-reviewed Risk factors Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

    Key finding: The proportion between women and men was significantly different (68.7% [95% CI 63.9-73.4 vs 31.4%, 95% CI 26.6-36.0]). +4 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →