Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 21,576–21,600 of 27,380 studies, newest first · page 864 of 1096.
March 2009 24
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2009-03-01
Mg2+ imparts NMDA receptor subtype selectivity to the Alzheimer's drug memantine
36/100 ✓ Peer-reviewed Treatments The Journal of neuroscience : the official journal of the Society for Neuroscience
Key finding: As a result, therapeutic memantine concentrations should have negligible effects on NR1/2A or NR1/2B receptor activity but pronounced effects on NR1/2C and NR1/2D receptors. +3 more findings
Full summary, score breakdown and related studies → Original source
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2009-03-01
Enriched environment restores hippocampal cell proliferation and ameliorates cognitive deficits in chronically stressed rats
36/100 ✓ Peer-reviewed Hippocampus size on brain scans Journal of neuroscience research
Key finding: We observed that chronic restraint stress severely affected formation of new cells and learning. +4 more findings
Full summary, score breakdown and related studies → Original source
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2009-03-01
Effects of Alzheimer's disease and mild cognitive impairment on driving ability: a controlled clinical study by simulated driving test
43/100 ✓ Peer-reviewed Clinical safety International journal of geriatric psychiatry
Key finding: Mild AD significantly impaired simulated driving fitness, while MCI limitedly affected driving performance. +4 more findings
Full summary, score breakdown and related studies → Original source
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2009-03-01
Cognitive training for early-stage Alzheimer's disease and dementia
36/100 ✓ Peer-reviewed Prevention trials Journal of gerontological nursing
Key finding: The purpose of this article is to critically review and synthesize the literature on the effects of nonpharmacological cognitive training on dementia symptoms in early-stage Alzheimer's disease (AD) and related dementia. +3 more findings
Full summary, score breakdown and related studies → Original source
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2009-03-01
Association of total tau and phosphorylated tau 181 protein levels in cerebrospinal fluid with cerebral atrophy in mild cognitive impairment and Alzheimer disease
35/100 ✓ Peer-reviewed Tau biomarkers Journal of psychiatry & neuroscience : JPN
Key finding: We sought to examine the association of levels of total tau (t-tau) and phosphorylated tau 181 (p-tau181) protein with brain morphology in mild cognitive impairment, as defined by the concept of aging-associated cognitive decline (AACD) and Alzheimer disease. +3 more findings
Full summary, score breakdown and related studies → Original source
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2009-03-01
Cerebrospinal fluid {beta}-amyloid 42 and tau proteins as biomarkers of Alzheimer-type pathologic changes in the brain
60/100 ✓ Peer-reviewed Tau biomarkers Archives of neurology
Key finding: There is a clear need to develop an objective diagnostic test for Alzheimer disease (AD). +3 more findings
Full summary, score breakdown and related studies → Original source
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2009-03-01
Visuospatial memory in healthy elderly, AD and MCI: a review
38/100 ✓ Peer-reviewed Mild cognitive impairment Current aging science
Key finding: Further, recent studies have suggested that the allocentric component of spatial memory might be taken as predictor of AD from MCI.
Full summary, score breakdown and related studies → Original source
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2009-03-01
Source-based morphometry: the use of independent component analysis to identify gray matter differences with application to schizophrenia
49/100 ✓ Peer-reviewed Lewy body dementia Human brain mapping
Key finding: Finally, statistical analyses are used to determine the significant sources and their relationship to other variables. +3 more findings
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2009-03-01
Midlife and late-life obesity and the risk of dementia: cardiovascular health study
61/100 ✓ Peer-reviewed Lewy body dementia Archives of neurology
Key finding: These results help explain the "obesity paradox" as differences in dementia risk across time are consistent with physical changes in the trajectory toward disability. +3 more findings
Full summary, score breakdown and related studies → Original source
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2009-03-01
The role of metabolic disorders in Alzheimer disease and vascular dementia: two roads converged
53/100 ✓ Peer-reviewed Risk factors Archives of neurology
Key finding: In recent years a rapidly increasing number of studies has focused on the relationship between dementia and metabolic disorders such as diabetes, obesity, hypertension, and dyslipidemia. +4 more findings
Full summary, score breakdown and related studies → Original source
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2009-03-01
The impact of the quality of relationship on the experiences and wellbeing of caregivers of people with dementia: a systematic review
55/100 ✓ Peer-reviewed Caregiving Aging & mental health
Key finding: Future research should examine both current and pre-caregiving relationship quality.
Full summary, score breakdown and related studies → Original source
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2009-03-01
Prevalence, correlates and course of behavioural and psychological symptoms of dementia in the population
64/100 ✓ Peer-reviewed Caregiving The British journal of psychiatry : the journal of mental science
Key finding: Behavioural and psychological symptoms of dementia affect nearly all people with dementia.
Full summary, score breakdown and related studies → Original source
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2009-03-01
Hippocampal atrophy rates in Alzheimer disease: added value over whole brain volume measures
58/100 ✓ Peer-reviewed Brain scans and imaging Neurology
Key finding: Whole brain atrophy rate discriminates Alzheimer disease (AD) from MCI.
Full summary, score breakdown and related studies → Original source
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2009-03-01
Progressive supranuclear palsy: clinicopathological concepts and diagnostic challenges
54/100 ✓ Peer-reviewed Getting a diagnosis The Lancet. Neurology
Key finding: Since the first description of PSP in 1963, several distinct clinical syndromes have been described that are associated with PSP; this discovery challenges the traditional clinicopathological definition and complicates diagnosis in the absence of a reliable, disease-specific biomarker.
Full summary, score breakdown and related studies → Original source
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2009-03-01
Montreal Cognitive Assessment Arabic version: reliability and validity prevalence of mild cognitive impairment among elderly attending geriatric clubs in Cairo
40/100 ✓ Peer-reviewed Prevention and risk Geriatrics & gerontology international
Key finding: Test-retest reliability data of the Arabic MoCA were collected approximately 35.0 +/- 17.6 days apart. +1 more finding
Full summary, score breakdown and related studies → Original source
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2009-03-01
Cognitive and sensory declines in old age: gauging the evidence for a common cause
57/100 ✓ Peer-reviewed Prevention and risk Psychology and aging
Key finding: The authors examined reliability-adjusted variances and covariances in longitudinal change for 8 cognitive measures and for close visual acuity, distant visual acuity, and hearing in 516 participants in the Berlin Aging Study (ages 70 to 103 years at 1st measurement). +4 more findings
Full summary, score breakdown and related studies → Original source
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2009-03-01
Fish consumption, long-chain omega-3 fatty acids and risk of cognitive decline or Alzheimer disease: a complex association
65/100 ✓ Peer-reviewed Prevention and risk Nature clinical practice. Neurology
Key finding: All three observational studies that used cognitive decline as an outcome reported significant benefits, whereas only four of eight observational studies that used incidence of AD or dementia as an outcome reported positive findings.
Full summary, score breakdown and related studies → Original source
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2009-03-01
Can cognitive exercise prevent the onset of dementia? Systematic review of randomized clinical trials with longitudinal follow-up
66/100 ✓ Peer-reviewed Prevention and risk The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
Key finding: Cognitive exercise training in healthy older individuals produces strong and persistent protective effects on longitudinal neuropsychological performance. +2 more findings
Full summary, score breakdown and related studies → Original source
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2009-03-01
Commentary on "A roadmap for the prevention of dementia II. Leon Thal Symposium 2008." The Multidomain Alzheimer Preventive Trial (MAPT): a new approach to the prevention of Alzheimer's disease
53/100 ✓ Peer-reviewed Treatments Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: The MAPT Study is the first preventive trial involving multidomain interventions. +1 more finding
Full summary, score breakdown and related studies → Original source
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2009-03-01
Alzheimer's Disease Anti-inflammatory Prevention Trial: design, methods, and baseline results
63/100 ✓ Peer-reviewed Treatments Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: Enrollment began in March 2001 and ended in December 2004 when treatments were suspended because of concerns regarding cardiovascular safety of the treatments.
Full summary, score breakdown and related studies → Original source
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2009-03-01
CSF biomarkers in relationship to cognitive profiles in Alzheimer disease
51/100 ✓ Peer-reviewed Genetics Neurology
Key finding: Clusters of CSF biomarker levels are related to cognitive profiles in Alzheimer disease.
Full summary, score breakdown and related studies → Original source
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2009-03-01
APOE epsilon2 is associated with intact cognition but increased Alzheimer pathology in the oldest old
50/100 ✓ Peer-reviewed Genetics Neurology
Key finding: In the oldest old, the presence of the APOE epsilon2 allele (APOE2) was associated with a somewhat reduced risk of dementia, but paradoxically was associated with increased Alzheimer disease (AD) neuropathology. +2 more findings
Full summary, score breakdown and related studies → Original source
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2009-03-01
Contribution of vascular risk factors to the progression in Alzheimer disease
50/100 ✓ Peer-reviewed Genetics Archives of neurology
Key finding: In generalized estimating equation models (adjusted for age, race/ethnicity, and years of education), higher cholesterol (total cholesterol and LDL-C) concentrations and history of diabetes were associated with faster cognitive decline. +2 more findings
Full summary, score breakdown and related studies → Original source
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2009-03-01
PGC-1alpha expression decreases in the Alzheimer disease brain as a function of dementia
53/100 ✓ Peer-reviewed Genetics Archives of neurology
Key finding: Therapeutic preservation of neuronal PGC-1alpha expression promotes the nonamyloidogenic processing of amyloid precursor protein precluding the generation of amyloidogenic Abeta peptides. +3 more findings
Full summary, score breakdown and related studies → Original source
February 2009 1
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2009-02-27
MRI of hippocampal volume loss in early Alzheimer's disease in relation to ApoE genotype and biomarkers
52/100 ✓ Peer-reviewed Hippocampus size on brain scans Brain : a journal of neurology
Key finding: Moreover, increased rates of hippocampal loss were associated with presence of the ApoE allele epsilon4 gene in Alzheimer's disease and lower CSF Abeta(1-42) in mild cognitive impairment, irrespective of ApoE genotype, whereas relations with tau were only trends.
Full summary, score breakdown and related studies → Original source
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