Newest studies

Olfaction and the 5-year incidence of cognitive impairment in an epidemiological study of older adults

56/100 ✓ Peer-reviewed Prevention and risk Journal of the American Geriatrics Society

Key finding: Olfactory impairment at baseline was strongly associated with 5-year incidence of cognitive impairment as measured using the MMSE. +3 more findings

• Risk Factors
• Diagnosis

Full summary, score breakdown and related studies → Original source

The role of amyloid precursor protein processing by BACE1, the beta-secretase, in Alzheimer disease pathophysiology

46/100 ✓ Peer-reviewed Risk genes beyond APOE The Journal of biological chemistry

Key finding: Abeta fulfills a central role in AD pathogenesis, and reduction of Abeta levels should prove beneficial for AD treatment. +3 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Amyloid precursor protein trafficking, processing, and function

55/100 ✓ Peer-reviewed Risk genes beyond APOE The Journal of biological chemistry

Key finding: APP is the precursor to the amyloid beta-protein (Abeta), the 38-43-amino acid residue peptide that is at the heart of the amyloid cascade hypothesis of Alzheimer disease (AD). +3 more findings

Full summary, score breakdown and related studies → Original source

Tensor-based morphometry as a neuroimaging biomarker for Alzheimer's disease: an MRI study of 676 AD, MCI, and normal subjects

57/100 ✓ Peer-reviewed Cognitive tests and assessment NeuroImage

Key finding: Using inverse-consistent 3D non-linear elastic image registration, we warped 676 individual brain MRI volumes to a population mean geometric template. +3 more findings

• Brain Scans
• Early Stage

Full summary, score breakdown and related studies → Original source

Sulcal morphology changes and their relationship with cortical thickness and gyral white matter volume in mild cognitive impairment and Alzheimer's disease

46/100 ✓ Peer-reviewed Mild cognitive impairment NeuroImage

Key finding: Moreover, we observed their relationships with cortical thickness and gyral white matter (WM) volume, while considering age effect. +3 more findings

• Early Stage
• Brain Scans

Full summary, score breakdown and related studies → Original source

Thyroid function and cognitive decline in the MRC Cognitive Function and Ageing Study

50/100 ✓ Peer-reviewed Cognitive tests and assessment Psychoneuroendocrinology

Key finding: The association between thyroid stimulating hormone (TSH), free thyroid hormone or thyroxine (FT4) levels and cognition was investigated at baseline and after a 2 year follow-up in 1047 participants over 64 years of age, without physical frailty or severe cognitive impairment at baseline. +3 more findings

Full summary, score breakdown and related studies → Original source

Progression of cerebral small vessel disease in relation to risk factors and cognitive consequences: Rotterdam Scan study

36/100 ✓ Peer-reviewed Vascular contributions Stroke

Key finding: Higher age, female sex, cigarette smoking, elevated blood pressure, and baseline lesion load were associated with small vessel disease progression. +4 more findings

• Risk Factors
• Other Dementias

Full summary, score breakdown and related studies → Original source

Amyloid beta-peptide levels in laser capture microdissected cornu ammonis 1 pyramidal neurons of Alzheimer's brain

38/100 ✓ Peer-reviewed Biomarkers Neuroreport

Key finding: Deposition of the amyloid beta-peptide (Abeta) is a pathophysiological event associated with Alzheimer's disease. +1 more finding

• Brain Biology

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Age-specific epigenetic drift in late-onset Alzheimer's disease

40/100 ✓ Peer-reviewed Genetics PloS one

Key finding: Yet, the complex, non-Mendelian disease etiology suggests that an epigenetic component could be involved. +1 more finding

• Genetics

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The Cortical Signature of Alzheimer's Disease: Regionally Specific Cortical Thinning Relates to Symptom Severity in Very Mild to Mild AD Dementia and is Detectable in Asymptomatic Amyloid-Positive Individuals

58/100 ✓ Peer-reviewed Brain scans and imaging Cerebral Cortex

Alzheimer's disease (AD) is associated with neurodegeneration in vulnerable limbic and heteromodal regions of the cerebral cortex, detectable in vivo using magnetic resonance imaging.

• Brain Scans

Full summary, score breakdown and related studies → Original source

The logopenic/phonological variant of primary progressive aphasia

56/100 ✓ Peer-reviewed Brain scans and imaging Neurology

Key finding: Logopenic progressive aphasia (LPA) is a distinctive variant of primary progressive aphasia. +3 more findings

• Brain Scans
• Other Dementias

Full summary, score breakdown and related studies → Original source

Neuroanatomical correlates of neuropsychiatric symptoms in Alzheimer's disease

47/100 ✓ Peer-reviewed Clinical safety Brain : a journal of neurology

Key finding: The objective of this study was to identify the regions of decreased grey matter (GM) volume which were associated with specific neuropsychiatric behaviours in patients with mild Alzheimer's disease. +3 more findings

• Brain Scans

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The NALP3 inflammasome is involved in the innate immune response to amyloid-beta

36/100 ✓ Peer-reviewed Inflammation and the immune system Nature immunology

Key finding: Insoluble materials such as crystals activate the inflammasome formed by the cytoplasmic receptor NALP3, which results in the release of IL-1 beta. +1 more finding

• Brain Biology

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Palliative care in advanced dementia; A mixed methods approach for the development of a complex intervention

74/100 ✓ Peer-reviewed End-of-life care BMC palliative care

Key finding: This will be vital in moving to a phase III trial that is pragmatic and feasible for these complex patients within the NHS. +1 more finding

• End-of-Life Care
• Clinical Trials

Full summary, score breakdown and related studies → Original source

Ventricular enlargement as a possible measure of Alzheimer's disease progression validated using the Alzheimer's disease neuroimaging initiative database

57/100 ✓ Peer-reviewed Mild cognitive impairment Brain : a journal of neurology

Key finding: Ventricular enlargement may be an objective and sensitive measure of neuropathological change associated with mild cognitive impairment (MCI) and Alzheimer's disease (AD), suitable to assess disease progression for multi-centre studies. +1 more finding

• Early Stage

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Lifespan mental activity predicts diminished rate of hippocampal atrophy

40/100 ✓ Peer-reviewed Hippocampus size on brain scans PloS one

Key finding: High level of complex mental activity across the lifespan was correlated with a reduced rate of hippocampal atrophy. +2 more findings

• Brain Scans

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Long-term cognitive outcome of delirium in elderly hip surgery patients. A prospective matched controlled study over two and a half years

72/100 ✓ Peer-reviewed Clinical safety Dementia and geriatric cognitive disorders

Key finding: The risk of dementia or MCI at follow-up is almost doubled in elderly hip surgery patients with postoperative delirium compared with at-risk patients without delirium. +2 more findings

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Prenatal activation of microglia induces delayed impairment of glutamatergic synaptic function

40/100 ✓ Peer-reviewed Disease mechanisms PloS one

Key finding: Our results demonstrate that prenatal inflammation is sufficient to induce synaptic alterations with delay. +2 more findings

• Brain Biology

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The amyloid precursor protein intracellular domain (AICD) as modulator of gene expression, apoptosis, and cytoskeletal dynamics-relevance for Alzheimer's disease

45/100 ✓ Peer-reviewed Risk genes beyond APOE Progress in neurobiology

Key finding: Numerous studies over the last two decades have demonstrated the neurotoxic properties of Abeta. +3 more findings

• Genetics

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Incident dementia and blood pressure lowering in the Hypertension in the Very Elderly Trial cognitive function assessment (HYVET-COG): a double-blind, placebo controlled trial

76/100 ✓ Peer-reviewed Getting a diagnosis The Lancet. Neurology

Key finding: Observational epidemiological studies have shown a positive association between hypertension and risk of incident dementia; however, the effects of antihypertensive therapy on cognitive function in controlled trials have been conflicting, and meta-analyses of the trials have not provided clear evidence of whether antihypertensive treatment reduces dementia incidence. +4 more findings

• Risk Factors
• Clinical Trials
• Treatments

Full summary, score breakdown and related studies → Original source

Lipoic acid as an anti-inflammatory and neuroprotective treatment for Alzheimer's disease

48/100 ✓ Peer-reviewed Cognitive tests and assessment Advanced drug delivery reviews

Key finding: Despite extensive research into the pathogenesis of AD, a neuroprotective treatment - particularly for the early stages of disease - remains unavailable for clinical use. +3 more findings

• Treatments
• Clinical Trials

Full summary, score breakdown and related studies → Original source

Long-term Course and Effectiveness of Combination Therapy in Alzheimer Disease

40/100 ✓ Peer-reviewed Treatments Alzheimer Disease & Associated Disorders

Key finding: Covarying for baseline scores, age, education, and duration of illness, the COMBO group had significantly lower mean annualized rates of deterioration in BDS and ADL scores compared with the CI (P<0.001; Cohen's dBDS=0.10-0.34 and dADL=0.23-0.46 at 1 to 2 y) and NO-RX groups (P<0.001; Cohen's dBDS=0.56-0.73 and dADL=0.32-0.48 at 1 to 2 y). +4 more findings

• Treatments

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Prevalence of cholinesterase inhibitors in subjects with dementia in Europe

41/100 ✓ Peer-reviewed Treatments Pharmacoepidemiology and drug safety

Key finding: In 2004, estimated prevalence of ChI use among subjects with dementia ranged from 3.0% in the Netherlands to 20.3% in France. +4 more findings

• Treatments

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Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease

36/100 ✓ Peer-reviewed Disease mechanisms The Journal of neuroscience : the official journal of the Society for Neuroscience

Key finding: We conclude that macroautophagy is constitutively active and highly efficient in healthy neurons and that the autophagic pathology observed in AD most likely arises from impaired clearance of AVs rather than strong autophagy induction alone.

• Brain Biology

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Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta

36/100 ✓ Peer-reviewed Vascular contributions Neuron

Key finding: The speed of recovery of the animals underscores the acutely reversible nature of the cognitive deficits associated with transgenic models of AD.

• Brain Biology

Full summary, score breakdown and related studies → Original source