Newest studies

Cognitive function over time in the Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT): results of a randomized, controlled trial of naproxen and celecoxib

69/100 ✓ Peer-reviewed Treatments Archives of neurology

Key finding: Use of naproxen or celecoxib did not improve cognitive function. +1 more finding

• Clinical Trials
• Treatments
• Brain Biology

Full summary, score breakdown and related studies → Original source

Mapping limbic network organization in temporal lobe epilepsy using morphometric correlations: insights on the relation between mesiotemporal connectivity and cortical atrophy

43/100 ✓ Peer-reviewed Hippocampus size on brain scans NeuroImage

Key finding: In TLE the pattern of correlations was similar to controls, suggesting that pathological processes in the EC affect the same networks that co-vary with the EC in the healthy brain. +1 more finding

• Brain Scans

Full summary, score breakdown and related studies → Original source

Promoter-wide hypermethylation of the ribosomal RNA gene promoter in the suicide brain

40/100 ✓ Peer-reviewed Hippocampus size on brain scans PloS one

Key finding: This is the first study to show aberrant regulation of the protein synthesis machinery in the suicide brain.

• Genetics

Full summary, score breakdown and related studies → Original source

Serum sphingomyelins and ceramides are early predictors of memory impairment

47/100 ✓ Peer-reviewed Biomarkers Neurobiology of aging

Key finding: SM and ceramides varied in relation to the timing of HVLT-delayed impairment: low levels were associated with cross-sectional impairment; high levels predicted incident impairment in asymptomatic individuals. +2 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Discrimination between Alzheimer disease, mild cognitive impairment, and normal aging by using automated segmentation of the hippocampus

43/100 ✓ Peer-reviewed Hippocampus size on brain scans Radiology

Key finding: This automated method can serve as an alternative to manual tracing and may thus prove useful in assisting with the diagnosis of AD.

• Brain Scans
• Early Stage
• Diagnosis

Full summary, score breakdown and related studies → Original source

Emotion recognition in Huntington's disease and frontotemporal dementia

41/100 ✓ Peer-reviewed Disparities Neuropsychologia

Key finding: Both HD and FTD groups were impaired compared to controls, deficits in HD being less severe. +1 more finding

• Other Dementias

Full summary, score breakdown and related studies → Original source

Identification of miRNA changes in Alzheimer's disease brain and CSF yields putative biomarkers and insights into disease pathways

36/100 ✓ Peer-reviewed Tau biomarkers Journal of Alzheimer's disease : JAD

Key finding: MicroRNAs have essential functional roles in brain development and neuronal specification but their roles in neurodegenerative diseases such as Alzheimer's disease (AD) is unknown. +3 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Neonate hippocampal volumes: prematurity, perinatal predictors, and 2-year outcome

52/100 ✓ Peer-reviewed Hippocampus size on brain scans Annals of neurology

Key finding: Hippocampal volumes were reduced in PT infants exposed to several perinatal events but were preserved in PT infants without these exposures. +3 more findings

• Brain Scans

Full summary, score breakdown and related studies → Original source

A critical literature review exploring the challenges of delivering effective palliative care to older people with dementia

48/100 ✓ Peer-reviewed End-of-life care Journal of clinical nursing

Key finding: This review reinforces the importance of providing appropriate palliative care to individuals suffering from end-stage dementia and identifies some of the barriers to extending such specialist palliative care provision. +2 more findings

• End-of-Life Care

Full summary, score breakdown and related studies → Original source

The ALS/PDC syndrome of Guam and the cycad hypothesis

40/100 ✓ Peer-reviewed Disease mechanisms Neurology

Key finding: These include a high, if not exclusive, restriction to the Chamorro population, familial occurrence, a regional variation on Guam itself, a definite persistence but with declining incidence, and a possible duplication in isolated villages on the Kii peninsula of Japan. +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Pin1 has opposite effects on wild-type and P301L tau stability and tauopathy

36/100 ✓ Peer-reviewed Disease mechanisms The Journal of clinical investigation

Key finding: The prolyl isomerase Pin1 binds and isomerizes tau and has been implicated in protecting against neurodegeneration, but whether such Pin1 regulation is affected by tau mutations is unknown. +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

123I-MIBG cardiac scintigraphy provides clues to the underlying neurodegenerative disorder in idiopathic REM sleep behavior disorder

50/100 ✓ Peer-reviewed Disease mechanisms Sleep

Key finding: Cardiac 123I-MIBG findings are similar among idiopathic RBD and the syndromes of PD and DLB, but differ from those of PSP and MSA. +3 more findings

• Lifestyle

Full summary, score breakdown and related studies → Original source

Vascular risk factors and Alzheimer's disease

52/100 ✓ Peer-reviewed Inflammation and the immune system Expert review of neurotherapeutics

Key finding: Experimentally, small striatal infarcts in the presence of high levels of amyloid in the brain exhibit a progression in infarct size over time with enhanced degree of cognitive impairment, AD-type pathology and neuroinflammation compared with striatal infarcts or high amyloid levels alone.

• Risk Factors

Full summary, score breakdown and related studies → Original source

First SNP for Alzheimer's disease implemented

26/100 ✓ Peer-reviewed Health systems and care delivery Disease management advisor

Key finding: Evercare recently rolled out its Medicare Advantage special needs plan designed specifically for people with chronic disease and dementia.

Full summary, score breakdown and related studies → Original source

Inflammatory aspects of Alzheimer disease and other neurodegenerative disorders

43/100 ✓ Peer-reviewed Inflammation and the immune system Journal of Alzheimer's disease : JAD

Key finding: The classic view that microglia exist primarily in either a resting or activated state needs to be broadened in view of recent results. +3 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

CSF biomarkers in frontotemporal lobar degeneration with known pathology

53/100 ✓ Peer-reviewed Tau biomarkers Neurology

Key finding: It is important to distinguish FTLD from other neurodegenerative diseases like Alzheimer disease (AD), but this may be difficult clinically because of atypical presentations. +3 more findings

• Biomarkers
• Other Dementias

Full summary, score breakdown and related studies → Original source

Mild cognitive impairment and everyday function: evidence of reduced speed in performing instrumental activities of daily living

38/100 ✓ Peer-reviewed Mild cognitive impairment The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

Key finding: Future research should address the question of whether performance-based functional measures, as well as simple queries regarding whether functional activities take longer than usual to complete, may improve the prediction of future cognitive decline and disease progression among those individuals in whom MCI represents impending dementia.

• Early Stage

Full summary, score breakdown and related studies → Original source

Risk profiles for mild cognitive impairment and progression to dementia are gender specific

59/100 ✓ Peer-reviewed Mild cognitive impairment Journal of neurology, neurosurgery, and psychiatry

Key finding: Men and women have different risk profiles for both MCI and progression to dementia.

• Early Stage

Full summary, score breakdown and related studies → Original source

DNA damage and repair: relevance to mechanisms of neurodegeneration

43/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Journal of neuropathology and experimental neurology

Key finding: DNA damage is a form of cell stress and injury that has been implicated in the pathogenesis of many neurologic disorders, including amyotrophic lateral sclerosis, Alzheimer disease, Down syndrome, Parkinson disease, cerebral ischemia, and head trauma. +4 more findings

Full summary, score breakdown and related studies → Original source

Cholesterol as a risk factor for dementia and cognitive decline: a systematic review of prospective studies with meta-analysis

61/100 ✓ Peer-reviewed Risk factors The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

Key finding: Compatible results were pooled using meta-analysis. +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Prevalence of idiopathic normal-pressure hydrocephalus in the elderly population of a Japanese rural community

45/100 ✓ Peer-reviewed Disparities Neurologia medico-chirurgica

Key finding: Five subjects (2.9%) demonstrated both ventricular enlargement and narrow CSF space at the high convexity/midline.

• Health Equity

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Antiretroviral therapy and central nervous system HIV type 1 infection

41/100 ✓ Peer-reviewed Disparities The Journal of infectious diseases

Key finding: Combination antiretroviral therapy (ART) has had a major impact on all aspects of CNS HIV-1 infection and disease. +4 more findings

• Treatments

Full summary, score breakdown and related studies → Original source

Antipsychotic therapy and short-term serious events in older adults with dementia

52/100 ✓ Peer-reviewed Caregiving Archives of internal medicine

Key finding: Serious events, as indicated by a hospital admission or death, are frequent following the short-term use of antipsychotic drugs in older adults with dementia. +1 more finding

• Side Effects
• Treatments

Full summary, score breakdown and related studies → Original source

Parkinson's disease-cognitive rating scale: a new cognitive scale specific for Parkinson's disease

51/100 ✓ Peer-reviewed Getting a diagnosis Movement disorders : official journal of the Movement Disorder Society

Key finding: Cognitive defects associated with cortical pathology may be a marker of dementia in Parkinson's disease (PD). +3 more findings

• Diagnosis
• Other Dementias

Full summary, score breakdown and related studies → Original source

Whole-brain atrophy rate in Alzheimer disease: identifying fast progressors

53/100 ✓ Peer-reviewed Genetics Neurology

Key finding: The mean whole-brain atrophy rate was -1.9 +/- 0.9% per year. +1 more finding

• Brain Scans
• Genetics

Full summary, score breakdown and related studies → Original source