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The Mayo Clinic Study of Aging: design and sampling, participation, baseline measures and sample characteristics
Roberts RO, Geda YE, Knopman DS, Cha RH, Pankratz VS, Boeve BF, Ivnik RJ, Tangalos EG et al.. Neuroepidemiology, 2008-02-07
Topic: Risk, prevention and care in population studies
Background The objective of this study was to establish a prospective population-based cohort to investigate the prevalence, incidence and risk factors for mild cognitive impairment (MCI) and dementia. Methods The Olmsted County, Minn., population, aged 70-89 years on October 1, 2004, was enumerated using the Rochester Epidemiology Project. Eligible subjects were randomly selected and invited to participate. Participants underwent a comprehensive in-person evaluation including the Clinical Dementia Rating Scale, a neurological evaluation and neuropsychological testing. A consensus diagnosis of normal cognition, MCI or dementia was made by a panel using previously published criteria. A subsample of subjects was studied via telephone interview. Results Four hundred and two subjects with dementia were identified from a detailed review of their medical records but were not contacted. At baseline, we successfully evaluated 703 women aged 70-79 years, 769 women aged 80-89 years, 730 men aged 70-79 years and 517 men aged 80-89 years (total n = 2,719). Among the participants, 2,050 subjects were evaluated in person and 669 via telephone. Conclusions Strengths of the study are that the subjects were randomly selected from a defined population, the majority of the subjects were examined in person, and MCI was defined using published criteria. Here, we report the design and sampling, participation, baseline measures and sample characteristics.
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APA 7th
Roberts, R. O., Geda, Y. E., Knopman, D. S., Cha, R. H., Pankratz, V. S., Boeve, B. F., et al. (2008). The Mayo Clinic Study of Aging: design and sampling, participation, baseline measures and sample characteristics. Neuroepidemiology. https://doi.org/10.1159/000115751
Vancouver
Roberts RO, Geda YE, Knopman DS, Cha RH, Pankratz VS, Boeve BF, et al. The Mayo Clinic Study of Aging: design and sampling, participation, baseline measures and sample characteristics. Neuroepidemiology. 2008. doi:10.1159/000115751. PMID: 18259084.
BibTeX
@article{roberts2008-18259084,
author = {Roberts, R. O. and Geda, Y. E. and Knopman, D. S. and Cha, R. H. and Pankratz, V. S. and Boeve, B. F. and Ivnik, R. J. and Tangalos, E. G. and others},
title = {{The Mayo Clinic Study of Aging: design and sampling, participation, baseline measures and sample characteristics}},
journal = {Neuroepidemiology},
year = {2008},
doi = {10.1159/000115751},
pmid = {18259084},
url = {https://doi.org/10.1159/000115751}
}
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Key findings
- Results Four hundred and two subjects with dementia were identified from a detailed review of their medical records but were not contacted.
Why it matters
This paper reports the design, sampling, and baseline characteristics of a population-based cohort study established to investigate the prevalence, incidence, and risk factors for mild cognitive impairment and dementia. It describes study methods and reports no treatment, cure, or prevention.
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Study details
- Participants2,719
- Evidence strengthModerate
How this study scored 58/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Neuroepidemiology) |
| Journal's citation record | 1 / 4 | Neuroepidemiology: journal h-index 125 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2008 — within 20 year(s) of the newest study here |
| Sample size | 3 / 4 | 2,719 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 6 / 7 | Cited 802 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 40.1 citations a year over 20 year(s) since 2008 |
| Impact for its field and year | 4 / 6 | Cited 13.0× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 4 / 6 | Cited by 97 other studies in this library |
| Still being cited | 3 / 4 | Cited 179 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Walter A. Rocca: h-index 118 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | Mayo Clinic: institution h-index 1,606 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 18259084) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 58 / 100 | — |
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