Newest studies

Disruptive behavior as a predictor in Alzheimer disease

51/100 ✓ Peer-reviewed Clinical safety Archives of neurology

Key finding: Disruptive behavior is very common in AD and predicts cognitive decline, functional decline, and institutionalization but not mortality. +2 more findings

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Nonpharmacological cognitive interventions in aging and dementia

36/100 ✓ Peer-reviewed Prevention trials Journal of geriatric psychiatry and neurology

Key finding: It is concluded that cognitive interventions in the elderly show considerable promise and deserve further study.

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The Classical Complement Cascade Mediates CNS Synapse Elimination

59/100 ✓ Peer-reviewed Inflammation and the immune system Cell

• Brain Biology

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Positron emission tomography imaging in dementia

42/100 ✓ Peer-reviewed Inflammation and the immune system The British journal of radiology

Key finding: Measurement of regional cerebral glucose metabolism (rCMR(glc)) using PET and [(18)F]-2-fluoro-2-deoxy-D-glucose (FDG) has become a standard technique in both oncology and dementia research. +3 more findings

• Brain Scans

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Where do you know what you know? The representation of semantic knowledge in the human brain

52/100 ✓ Peer-reviewed Brain tissue and pathology Nature reviews. Neuroscience

Key finding: Then, pointing at the sheep in the field, he asked her "What are those things?" +1 more finding

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Incidence and prognosis of transient neurological attacks

50/100 ✓ Peer-reviewed Long-term cohort studies JAMA

Key finding: Transient neurological attacks (TNAs) are attacks with temporary ( Objective To study the incidence and prognosis of focal TNAs (or TIAs), nonfocal TNAs, and mixed TNAs. +3 more findings

• Risk Factors

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Clinical prediction of Alzheimer disease dementia across the spectrum of mild cognitive impairment

63/100 ✓ Peer-reviewed Cognitive tests and assessment Archives of general psychiatry

Key finding: From a longitudinal study of normal (Clinical Dementia Rating [CDR] = 0; n = 77) and mildly impaired (CDR = 0.5; n = 167) participants with 5 or more annual clinical assessments, baseline level of cognitive impairment in daily life was graded using CDR sum of boxes (CDR-SB) and level of cognitive performance impairment was graded using neuropsychological test scores. +3 more findings

• Early Stage

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Glial cell dysregulation: a new perspective on Alzheimer disease

36/100 ✓ Peer-reviewed Risk genes beyond APOE Neurotoxicity research

Key finding: Several mechanisms have been postulated to explain its pathogenesis, beta-amyloid (A beta toxicity, cholinergic dysfunction, Tau hyper-phosphorylation, oxidative damage, synaptic dysfunction and inflammation secondary to senile plaques, among others. +3 more findings

• Brain Biology

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Lifetime risk of stroke and dementia: current concepts, and estimates from the Framingham Study

50/100 ✓ Peer-reviewed Caregiving The Lancet. Neurology

Key finding: Community-based data on a group of North Americans of European descent indicate that the lifetime risk of stroke for a middle-aged woman is 1 in 5 and for a middle-aged man is 1 in 6.

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Conversion of amnestic Mild Cognitive Impairment to dementia of Alzheimer type is independent to memory deterioration

47/100 ✓ Peer-reviewed Brain scans and imaging International journal of geriatric psychiatry

Key finding: In subjects with aMCI poor global cognitive performance at baseline, the worsening on executive functions and on functional status but not the worsening on memory functions are independently associated with the conversion to dementia of Alzheimer type at 1 year, follow-up. +2 more findings

• Early Stage

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Diagnostic procedures for Parkinson's disease dementia: recommendations from the movement disorder society task force

55/100 ✓ Peer-reviewed Getting a diagnosis Movement disorders : official journal of the Movement Disorder Society

Key finding: Level I is aimed primarily at the clinician with no particular expertise in neuropsychological methods, but who requires a simple, pragmatic set of tests that are not excessively time-consuming. +4 more findings

• Diagnosis
• Other Dementias

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Hypertension and the risk of mild cognitive impairment

62/100 ✓ Peer-reviewed Prevention and risk Archives of neurology

Key finding: A history of hypertension is related to a higher risk of MCI. +4 more findings

• Risk Factors
• Early Stage
• Prevention

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Persistence of contradicted claims in the literature

49/100 ✓ Peer-reviewed Treatments JAMA

Key finding: For the 2 vitamin E epidemiological studies, even in 2005, 50% of citing articles remained favorable. +3 more findings

• Clinical Trials

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Multicenter assessment of CSF-phosphorylated tau for the prediction of conversion of MCI

55/100 ✓ Peer-reviewed Genetics Neurology

Key finding: An a priori defined cutoff value of p-tau(231) yields relatively stable results across centers, suggesting a good feasibility of a standard criterion of p-tau(231) for the prediction of Alzheimer disease. +1 more finding

• Early Stage
• Biomarkers
• Genetics

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Mature astrocytes in the adult human neocortex express the early neuronal marker doublecortin

49/100 ✓ Peer-reviewed Biomarkers Brain : a journal of neurology

Key finding: Markers of glial activation, such as GFAP and HLA, were not associated with DCX immunoreactivity, however, the presence of cytoarchitectural alterations tended to correlate with reduced DCX staining of astrocytic somata. +1 more finding

• Brain Biology

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Multi-target-directed drug design strategy: from a dual binding site acetylcholinesterase inhibitor to a trifunctional compound against Alzheimer's disease

36/100 ✓ Peer-reviewed Treatments Journal of medicinal chemistry

Key finding: A design strategy to convert a dual-binding site AChE inhibitor into triple functional compounds with promising in vitro profile against multifactorial syndromes, such as Alzheimer's disease, is proposed. +2 more findings

• Treatments

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An additional human chromosome 21 causes suppression of neural fate of pluripotent mouse embryonic stem cells in a teratoma model

37/100 ✓ Peer-reviewed Biomarkers BMC developmental biology

Key finding: We demonstrate that a supernumerary chromosome 21 causes Inhibition of Neuroectodermal DIfferentiation (INDI) of pluripotent ES cells. +2 more findings

• Brain Biology

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Gait variability is associated with subclinical brain vascular abnormalities in high-functioning older adults

48/100 ✓ Peer-reviewed Caregiving Neuroepidemiology

Key finding: In this group of older adults free from neurodegenerative diseases, a greater variability of step length was associated with greater burden of subclinical brain vascular abnormalities as defined by MRI. +2 more findings

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Atrophy rates accelerate in amnestic mild cognitive impairment

52/100 ✓ Peer-reviewed Brain scans and imaging Neurology

Key finding: Rates of atrophy accelerate as individuals progress from amnestic mild cognitive impairment (aMCI) to typical late onset Alzheimer disease (AD).

• Brain Scans
• Early Stage

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Late-life body mass index and dementia incidence: nine-year follow-up data from the Kungsholmen Project

49/100 ✓ Peer-reviewed Brain tissue and pathology Journal of the American Geriatrics Society

Key finding: Three-, 6-, and 9-year follow-up study. +3 more findings

• Risk Factors

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Mild cognitive impairment: epidemiology and dementia risk in an elderly Italian population

63/100 ✓ Peer-reviewed Mild cognitive impairment Journal of the American Geriatrics Society

Key finding: MCI occurs often in this elderly Italian cohort and is associated with greater risk of AD, but only when the impairment involves the memory domain. +2 more findings

• Early Stage
• Risk Factors

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Natural history of decline in instrumental activities of daily living performance over the 10 years preceding the clinical diagnosis of dementia: a prospective population-based study

64/100 ✓ Peer-reviewed Getting a diagnosis Journal of the American Geriatrics Society

Key finding: This study is the first to show that, 10 years before the clinical diagnosis of dementia, subjects who later developed dementia performed worse in complex activities of daily living, which may constitute an early marker of the disease. +1 more finding

• Diagnosis

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Neuropathological changes in essential tremor: 33 cases compared with 21 controls

60/100 ✓ Peer-reviewed Lewy body dementia Brain : a journal of neurology

Key finding: The mean number of Purkinje cells per 100x field was reduced in ET cases without Lewy bodies (6.6 +/- 2.4 versus 9.6 +/- 3.4, P < 0.01), and there were approximately 7x more Purkinje cell torpedoes per section (12.6 +/- 7.9 versus 1.7 +/- 1.4, P < 0.001) compared to controls. +1 more finding

• Brain Biology

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Pulse pressure and pulse wave velocity are related to cognitive decline in the Baltimore Longitudinal Study of Aging

68/100 ✓ Peer-reviewed Getting a diagnosis Hypertension (Dallas, Tex. : 1979)

Key finding: Pulse pressure and pulse wave velocity, markers of arterial stiffness, have been associated with stroke, dementia, and lowered levels of cognitive function. +2 more findings

• Diagnosis

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Alzheimer disease models and human neuropathology: similarities and differences

43/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Acta neuropathologica

Key finding: Mutated human APP transgenes result in the deposition of Abeta peptide, similar but not identical to the Abeta peptide of human senile plaque.

• Brain Biology

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