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NFkappaB-dependent control of BACE1 promoter transactivation by Abeta42
Buggia-Prevot V, Sevalle J, Rossner S, Checler F.. The Journal of biological chemistry, 2008-02-08
Topic: Brain proteins, microglia and lab models
Beta-amyloid (Abeta) peptides that accumulate in Alzheimer disease are generated from the beta-amyloid precursor protein (betaAPP) by cleavages by beta-secretase BACE1 and by presenilin-dependent gamma-secretase activities. Very few data document a putative cross-talk between these proteases and the regulatory mechanisms underlying such interaction. We show that presenilin deficiency lowers BACE1 maturation and affects both BACE1 activity and promoter transactivation.
Key findings
- Very few data document a putative cross-talk between these proteases and the regulatory mechanisms underlying such interaction.
- We show that presenilin deficiency lowers BACE1 maturation and affects both BACE1 activity and promoter transactivation.
- The specific gamma-secretase inhibitor DFK167 triggers the decrease of BACE1 activity in wild-type but not in presenilin-deficient fibroblasts.
- This decrease is also elicited by catalytically inactive gamma-secretase.
Why it matters
In cell studies, presenilin deficiency and γ-secretase inhibition lowered BACE1 maturation and activity, and amyloid β42 controlled BACE1 promoter transactivation through NFkappaB. This is laboratory cell research and does not show a treatment, cure, or prevention.
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Study details
- Evidence strengthLow
How this study scored 46/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (The Journal of biological chemistry) |
| Journal's citation record | 4 / 4 | Journal of Biological Chemistry: journal h-index 780 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2008 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 125 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 6.2 citations a year over 20 year(s) since 2008 |
| Impact for its field and year | 3 / 6 | Cited 5.6× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 5 other studies in this library |
| Still being cited | 1 / 4 | Cited 5 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Frédéric Checler: h-index 77 (OpenAlex, whole career) |
| Institution's track record | 3 / 3 | Centre National de la Recherche Scientifique: institution h-index 2,511 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 4 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 18263584) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 46 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1074/jbc.m706579200
- PubMed: 18263584
- Original source →
- Free full text: Journal of Biological Chemistry →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Buggia-Prevot, V., Sevalle, J., Rossner, S., & Checler, F. (2008). NFkappaB-dependent control of BACE1 promoter transactivation by Abeta42. The Journal of biological chemistry. https://doi.org/10.1074/jbc.m706579200
Vancouver
Buggia-Prevot V, Sevalle J, Rossner S, Checler F. NFkappaB-dependent control of BACE1 promoter transactivation by Abeta42. The Journal of biological chemistry. 2008. doi:10.1074/jbc.m706579200. PMID: 18263584.
BibTeX
@article{buggiaprevot2008-18263584,
author = {Buggia-Prevot, V. and Sevalle, J. and Rossner, S. and Checler, F.},
title = {{NFkappaB-dependent control of BACE1 promoter transactivation by Abeta42}},
journal = {The Journal of biological chemistry},
year = {2008},
doi = {10.1074/jbc.m706579200},
pmid = {18263584},
url = {https://doi.org/10.1074/jbc.m706579200}
}
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