Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 24,701–24,725 of 27,380 studies, newest first · page 989 of 1096.
November 2002 9
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2002-11-01
Dementia and Alzheimer disease incidence: a prospective cohort study
61/100 ✓ Peer-reviewed How common it is Archives of neurology
Key finding: Two hundred fifteen cases of dementia and 151 cases of AD were diagnosed. +2 more findings
Full summary, score breakdown and related studies → Original source
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2002-11-01
Use of lipid-lowering drugs in older adults with and without dementia: a community-based epidemiological study
50/100 ✓ Peer-reviewed Disparities Journal of the American Geriatrics Society
Key finding: Demented individuals were less likely than their nondemented counterparts to be taking lipid-lowering drugs. +3 more findings
Full summary, score breakdown and related studies → Original source
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2002-11-01
Attitudes towards euthanasia among physicians, nurses and the general public in Finland
32/100 ✓ Peer-reviewed Disparities Public health
Key finding: This paper conclude that PE was largely accepted among Finnish medical professionals and the general public.
Full summary, score breakdown and related studies → Original source
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2002-11-01
Abundant tau filaments and nonapoptotic neurodegeneration in transgenic mice expressing human P301S tau protein
53/100 ✓ Peer-reviewed Disparities The Journal of neuroscience : the official journal of the Society for Neuroscience
Key finding: Sarkosyl-insoluble tau from brains and spinal cords of transgenic mice ran as a hyperphosphorylated 64 kDa band, the same apparent molecular mass as that of the 383 aa tau isoform in the human tauopathies. +4 more findings
Full summary, score breakdown and related studies → Original source
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2002-11-01
Office of Rare Diseases neuropathologic criteria for corticobasal degeneration
53/100 ✓ Peer-reviewed Getting a diagnosis Journal of neuropathology and experimental neurology
Key finding: The methods required to make this diagnosis include histologic stains to assess neuronal loss, spongiosis and ballooned neurons, and a method to detect tau-positive neuronal and glial lesions. +4 more findings
Full summary, score breakdown and related studies → Original source
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2002-11-01
Hormone replacement therapy and incidence of Alzheimer disease in older women: the Cache County Study
56/100 ✓ Peer-reviewed Getting a diagnosis JAMA
Key finding: Prior HRT use is associated with reduced risk of AD, but there is no apparent benefit with current HRT use unless such use has exceeded 10 years. +4 more findings
Full summary, score breakdown and related studies → Original source
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2002-11-01
Vascular basis of Alzheimer's pathogenesis
42/100 ✓ Peer-reviewed Prevention and risk Annals of the New York Academy of Sciences
Key finding: Considerable evidence now indicates that Alzheimer's disease (AD) is primarily a vascular disorder. +1 more finding
Full summary, score breakdown and related studies → Original source
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2002-11-01
Identifying the elderly at risk for malnutrition. The Mini Nutritional Assessment
45/100 ✓ Peer-reviewed Prevention and risk Clinics in geriatric medicine
Key finding: In community-dwelling elderly persons, the MNA detects risk of malnutrition and life-style characteristics associated with nutritional risk while albumin levels and the BMI are still in the normal range.
Full summary, score breakdown and related studies → Original source
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2002-11-01
Subcortical ischaemic vascular dementia
54/100 ✓ Peer-reviewed Prevention and risk The Lancet. Neurology
Key finding: SIVD results from small-vessel disease, which produces either arteriolar occlusion and lacunes or widespread incomplete infarction of white matter due to critical stenosis of medullary arterioles and hypoperfusion (Binswanger's disease). +1 more finding
Full summary, score breakdown and related studies → Original source
October 2002 16
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2002-10-24
Lipoprotein lipase: structure, function, regulation, and role in disease
36/100 ✓ Peer-reviewed Risk factors Journal of molecular medicine (Berlin, Germany)
Key finding: Research carried out over the past two decades have not only established a central role for LPL in the overall lipid metabolism and transport but have also identified additional, non-catalytic functions of the enzyme. +1 more finding
Full summary, score breakdown and related studies → Original source
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2002-10-24
Alzheimer's Disease Is a Synaptic Failure
60/100 ✓ Peer-reviewed Disease mechanisms Science
In its earliest clinical phase, Alzheimer's disease characteristically produces a remarkably pure impairment of memory.
Full summary, score breakdown and related studies → Original source
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2002-10-23
The Apathy Inventory: assessment of apathy and awareness in Alzheimer's disease, Parkinson's disease and mild cognitive impairment
45/100 ✓ Peer-reviewed Clinical safety International Journal of Geriatric Psychiatry
Key finding: Internal consistency, item reliability, and between-rater reliability were high. +4 more findings
Full summary, score breakdown and related studies → Original source
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2002-10-15
Generation of antibodies specific for beta-amyloid by vaccination of patients with Alzheimer disease
63/100 ✓ Peer-reviewed Risk genes beyond APOE Nature medicine
Key finding: We collected sera from patients with Alzheimer disease who received a primary injection of pre-aggregated Abeta42 followed by one booster injection in a placebo-controlled study. +3 more findings
Full summary, score breakdown and related studies → Original source
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2002-10-04
Tau filament formation and associative memory deficit in aged mice expressing mutant (R406W) human tau
36/100 ✓ Peer-reviewed Disease mechanisms Proceedings of the National Academy of Sciences of the United States of America
Key finding: As with human cases, tau inclusions were composed of both mutant and endogenous wild-type tau, and were associated with microtubule disruption and flame-shaped transformations of the affected neurons. +1 more finding
Full summary, score breakdown and related studies → Original source
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2002-10-01
Metalloenzyme-like Activity of Alzheimer's Disease β-Amyloid
40/100 ✓ Peer-reviewed Risk factors Journal of Biological Chemistry
Key finding: Cholesterol is an important substrate for this activity, as are vitamin C, L-DOPA, and dopamine (V(max) for dopamine = 34.5 nm/min, K(m) = 8.9 microm). +4 more findings
Full summary, score breakdown and related studies → Original source
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2002-10-01
Synergistic effects of pesticides and metals on the fibrillation of alpha-synuclein: implications for Parkinson's disease
36/100 ✓ Peer-reviewed Risk factors Neurotoxicology
Key finding: The etiology of PD is unknown, but recent work has shown that except in rare cases, there appears to be no direct genetic basis.
Full summary, score breakdown and related studies → Original source
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2002-10-01
Acetylcholinesterase inhibitory activity of some Amaryllidaceae alkaloids and Narcissus extracts
36/100 ✓ Peer-reviewed Treatments Life sciences
Key finding: Amaryllidaceous plants produce pharmacologically active alkaloids, galanthamine being the most interesting for its use in the treatment of Alzheimer's disease as a cholinesterase inhibitor. +3 more findings
Full summary, score breakdown and related studies → Original source
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2002-10-01
Diagnostic strategies in CADASIL
40/100 ✓ Peer-reviewed Vascular contributions Neurology
Key finding: The spectrum of mutations in this study can be used to plan appropriate screening protocols; a suggested protocol is to screen exon 4, and proceed to exons 3, 5, and 6 where indicated. +2 more findings
Full summary, score breakdown and related studies → Original source
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2002-10-01
Pneumonia: the demented patient's best friend? Discomfort after starting or withholding antibiotic treatment
52/100 ✓ Peer-reviewed End-of-life care Journal of the American Geriatrics Society
Key finding: Irrespective of antibiotic treatment, pneumonia causes substantial suffering in demented patients. +1 more finding
Full summary, score breakdown and related studies → Original source
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2002-10-01
The experience of dying: an ethnographic nursing home study
38/100 ✓ Peer-reviewed End-of-life care The Gerontologist
Key finding: The review of the literature disclosed that research on the experience of dying is limited; most of the studies have been conducted in acute care hospitals among people who were dying of cancer.
Full summary, score breakdown and related studies → Original source
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2002-10-01
A Commentary
31/100 ✓ Peer-reviewed Health systems and care delivery The Gerontologist
Key finding: Planned transitions among settings need to be carried out with grace, redundancy of information and accountability, and patient/family involvement. +4 more findings
Full summary, score breakdown and related studies → Original source
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2002-10-01
Human brain parenchymal microglia express CD14 and CD45 and are productively infected by HIV-1 in HIV-1 encephalitis
42/100 ✓ Peer-reviewed Inflammation and the immune system Brain pathology (Zurich, Switzerland)
Key finding: They play significant roles in a number of human CNS diseases including AIDS dementia. +3 more findings
Full summary, score breakdown and related studies → Original source
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2002-10-01
The role of macrophage/microglia and astrocytes in the pathogenesis of three neurologic disorders: HIV-associated dementia, Alzheimer disease, and multiple sclerosis
44/100 ✓ Peer-reviewed Inflammation and the immune system Journal of the neurological sciences
Key finding: Astrocytes, as a significant component of the blood-brain barrier, behave as one of the immune effector cells in the CNS as well. +3 more findings
Full summary, score breakdown and related studies → Original source
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2002-10-01
Alzheimer's disease and the basal forebrain cholinergic system: relations to beta-amyloid peptides, cognition, and treatment strategies
50/100 ✓ Peer-reviewed Brain tissue and pathology Progress in neurobiology
Key finding: Brains from AD patients show several distinct neuropathological features, including extracellular beta-amyloid-containing plaques, intracellular neurofibrillary tangles composed of abnormally phosphorylated tau, and degeneration of cholinergic neurons of the basal forebrain. +3 more findings
Full summary, score breakdown and related studies → Original source
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2002-10-01
Mild cognitive impairment with subcortical vascular features: clinical characteristics and outcome
42/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of neurology
Key finding: Patients were enrolled in a prospective study on early cognitive impairment carried out in a Memory Clinic. +3 more findings
Full summary, score breakdown and related studies → Original source
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