Newest studies

Lecanemab and Donanemab Combination Therapy for Alzheimer’s Disease-The Cocktail May Work Even Better Together

28/100 ✓ Peer-reviewed Treatments Alzheimer Disease & Associated Disorders

Key finding: Lecanemab and Donanemab are two new FDA-approved antiamyloid immunotherapies that are Alzheimer disease modifying agents. +4 more findings

• Treatments

Full summary, score breakdown and related studies → Original source

Mapping sex differences in brain and cognition in relation to APOE ε4 and amyloid burden: A longitudinal normative modelling study

43/100 ✓ Peer-reviewed Genetics Alzheimer s & Dementia Translational Research & Clinical Interventions

Key finding: These findings highlight normative modelling's utility in revealing the complex interplay among sex, age, and AD risk in shaping brain structure and cognition in later life. +4 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

Tek Bir Gen Alzheimer Vakalarının Büyük Bölümünü Açıklayabilir

26/100 ✓ Peer-reviewed Genetics üha

Key finding: Yeni bilimsel araştırma, Alzheimer hastalığının %90’ından fazlasının APOE geniyle bağlantılı olabileceğini ortaya koydu. +1 more finding

Full summary, score breakdown and related studies → Original source

Additive value of early-phase β-Amyloid-PET for the differential diagnosis of non-Alzheimer’s disease dementia

40/100 ✓ Peer-reviewed Biomarkers NeuroImage Clinical

Key finding: Neurodegeneration status was correctly identified in 78.8% (119/151) of amyloid-negative patients through visual rating, compared to 67.5% (102/151) using logistic regression. +4 more findings

• Diagnosis
• Brain Scans

Full summary, score breakdown and related studies → Original source

Effects of Low‐Intensity Ultrasound on Amyloid‐ β Clearance in Early‐Stage Alzheimer′s Disease: A Potential Role of Glymphatic Activity

40/100 ✓ Peer-reviewed Biomarkers Acta Neurologica Scandinavica

Key finding: LIUS was safe and demonstrated both cognitive improvement and reduced amyloid deposition in early‐stage AD. +4 more findings

• Brain Scans

Full summary, score breakdown and related studies → Original source

Comparative Prognostic Performance of Hippocampal Volume and Plasma Biomarkers in Amyloid-Negative Subjective Cognitive Decline: A Four-Year Follow-up

43/100 ✓ Peer-reviewed Biomarkers Journal of Clinical Neurology

Key finding: Fourteen participants (21.5%) converted to MCI, and 24 (36.9%) were classified as Prog-1.Plasma biomarkers did not show consistent predictive performance across predefined endpoints (all p>0.05), although NfL demonstrated modest discrimination for MCI conversion (area under the curve [AUC] 0.686, p=0.008).Hippocampal volume demonstrated significant discriminative performance for MCI conversion (AUC 0.765, p=0.016) and Prog-1 (AUC 0.933, p<0.001).For Prog-2, hippocampal volume showed high discrimination (AUC 0.952, p<0.001).WMH grade also demonstrated significant discrimination for MCI conversion (AUC 0.835, p<0.001) and Prog-1 (AUC 0.857, p<0.001).Bootstrap analyses (1,000 iterations) tended to show higher AUC estimates for imaging markers compared with plasma biomarkers. +1 more finding

• Biomarkers
• Brain Scans
• Early Stage

Full summary, score breakdown and related studies → Original source

Predicting low premorbid cognitive ability with social determinants: A machine learning approach

31/100 ✓ Peer-reviewed Risk factors Journal of Aging Research and Lifestyle

Key finding: The model achieved and AUC of 0.72 [0.64, 0.81]. +3 more findings

• Health Equity

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Older adults in more disadvantaged neighborhoods exhibit brain vascular dysfunction

31/100 ✓ Peer-reviewed Risk factors Cerebral Circulation - Cognition and Behavior

Key finding: Greater neighborhood deprivation was associated with lower whole-brain CVR when adjusted for age and sex ( p = 0.027). +2 more findings

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When context matters: social disparities in preventable hospitalizations among Medicare beneficiaries with dementia

36/100 ✓ Peer-reviewed Risk factors Innovation in Aging

Key finding: Urinary tract infection (33.8%), heart failure (25.7%), and pneumonia (18.6%) accounted for 78% of all PPHs. +4 more findings

• Health Equity
• Care Services
• Policy

Full summary, score breakdown and related studies → Original source

Multilevel prediction of Alzheimer's disease dementia in the United States: An artificial intelligence analysis

39/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring

Key finding: = 0.75) of the variance in AD prevalence. +3 more findings

• Health Equity

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Why Is Community-Based Palliative Care Declined? Older Adult, Caregiver, and Provider Perspectives

32/100 ✓ Peer-reviewed Health systems and care delivery Journal of palliative medicine

Key finding: Reasons for declining included mis-association with hospice, not seeing additional benefit to current care, and reluctance to change current care. +2 more findings

• Caregiving
• End-of-Life Care

Full summary, score breakdown and related studies → Original source

From Attitudes to Action, Primary Care Alzheimer's Detection: How Knowledge, Confidence, and Clinic Capacity Predict Actual Screening and Referral Behavior

27/100 ✓ Peer-reviewed Health systems and care delivery Medical Research Archives

Key finding: However, knowledge alone does not consistently predict screening behavior. +3 more findings

• Diagnosis
• Care Services

Full summary, score breakdown and related studies → Original source

Lifestyle medicine: Our only hope against the ticking non-communicable diseases time bomb

46/100 ✓ Peer-reviewed Risk factors The Journal of Clinical and Scientific Research

Key finding: MODERN MEDICINE VERSUS LIFESTYLE MEDICINE Conventional biomedicine excels in acute care, diagnostics, therapeutics and emergencies. +4 more findings

• Risk Factors
• Lifestyle

Full summary, score breakdown and related studies → Original source

Dietary sodium intake: evidence, controversies and practical recommendations

29/100 ✓ Peer-reviewed Risk factors Nutrición Hospitalaria

Key finding: Excess salt intake is one of the relevant dietary determinants of elevated blood pressure and hypertension, with a direct impact on cardiovascular risk. +1 more finding

• Risk Factors
• Lifestyle

Full summary, score breakdown and related studies → Original source

The Diagnostic Role of FDG-PET in Dementias Presenting with Language and Behavioral Symptom

28/100 ✓ Peer-reviewed Tau biomarkers Turk psikiyatri dergisi = Turkish journal of psychiatry

Key finding: This study aimed to assess the diagnostic contribution of Fluorodeoxyglucose Positron Emission Tomography (FDG-PET) in neurodegenerative dementias presenting with language-predominant symptoms, with or without accompanying behavioral changes, and to evaluate the correspondence between PET-derived metabolic patterns and cerebrospinal fluid (CSF) biomarkers. +3 more findings

• Brain Scans
• Biomarkers
• Diagnosis

Full summary, score breakdown and related studies → Original source

Plasma Phosphorylated Tau 217 and Amyloid Burden in Older Adults Without Cognitive Impairment: A Meta-Analysis

72/100 ✓ Peer-reviewed Biomarkers JAMA neurology

Key finding: These findings demonstrate that plasma p-tau217 can reliably detect AD pathology in the preclinical stage. +3 more findings

• Biomarkers

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Cost-effectiveness of multimodal intervention for the prevention of dementia in Japan

39/100 ✓ Peer-reviewed Costs and economics The journal of prevention of Alzheimer's disease

Key finding: J-MINT demonstrates cost-effectiveness by reducing overall care costs while improving QALYs in individuals with MCI. +3 more findings

• Policy
• Prevention

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Resistance training and subcortical vascular cognitive impairment: A 12-month randomized trial

65/100 ✓ Peer-reviewed Treatments Alzheimer's & Dementia

Key finding: PRT may have a small beneficial effect on cognitive function in SVCI. +4 more findings

• Clinical Trials
• Other Dementias

Full summary, score breakdown and related studies → Original source

Effect of a 24-week resistance exercise intervention on cognitive function in cognitively normal older adults: The AGUEDA randomized controlled trial

67/100 ✓ Peer-reviewed Prevention and risk Alzheimer's & Dementia

Key finding: Although no overall EF benefit was observed, RE improved attentional/inhibitory control in cognitively normal older adults. +3 more findings

• Clinical Trials
• Early Stage
• Lifestyle

Full summary, score breakdown and related studies → Original source

Herpes zoster vaccination and incident dementia in Canada: an analysis of natural experiments

72/100 ✓ Peer-reviewed Prevention and risk The Lancet Neurology

Key finding: We aimed to determine the effect of live attenuated herpes zoster vaccination on incident dementia diagnoses among people aged 70 years and older using a natural experiment in Ontario, Canada, and to triangulate these findings, using a second natural experiment in Ontario and a quasi-experimental approach that uses data from multiple Canadian provinces. +2 more findings

• Prevention
• Risk Factors

Full summary, score breakdown and related studies → Original source

The glymphatic system clears amyloid beta and tau from brain to plasma in humans

73/100 ✓ Peer-reviewed Laboratory science Nature Communications

Key finding: 48 healthy, cognitively intact adults (ages 49-66) studied in randomized crossover design across two clinical trial registrations (NCT06060054, NCT06222385) +3 more findings

• Clinical Trials
• Brain Biology

Full summary, score breakdown and related studies → Original source

Efficacy and safety of oral semaglutide 14 mg (flexible dose) in early-stage symptomatic Alzheimer's disease (EVOKE and EVOKE+): two phase 3, randomised, placebo-controlled trials

81/100 ✓ Peer-reviewed Clinical trials The Lancet

Key finding: Combined enrollment 3,808 (EVOKE n=1,855; EVOKE+ n=1,953) across 566 sites/40 countries; Phase 3, randomized, double-blind, placebo-controlled, sponsored by Novo Nordisk +3 more findings

• Clinical Trials
• Treatments
• Side Effects

Full summary, score breakdown and related studies → Original source

A Biophysical Framework for Neurodegeneration: Prioritizing Protein Homeostasis Over Aggregate Toxicity

16/100 ⚠ Preprint — not yet peer-reviewed Treatments Preprints.org

Key finding: Neurodegenerative research has long hypothesized that aggregated proteins such as amyloid‑β (Aβ), tau, and α‑synuclein (αSyn) are intrinsically toxic and are directly associated with the etiologies of Alzheimer’s disease (AD) and Parkinson’s disease (PD).

• Treatments
• Side Effects
• Brain Biology

Scored 19 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Dysfunctional resting state network connectivity predicts postoperative delirium after major surgery

52/100 ✓ Peer-reviewed Brain scans and imaging British journal of anaesthesia

Key finding: Group comparisons revealed significantly decreased within-network connectivity in salience-ventral attention, cognitive control, and default mode network in participants with postoperative delirium (n=31) compared with non-delirious participants (n=89; non-parametric permutation test, 1000 iterations, P<0.05). +4 more findings

Full summary, score breakdown and related studies → Original source

The association of Alzheimer's disease and related dementias blood‐based biomarkers with depressive symptoms

46/100 ✓ Peer-reviewed Inflammation and the immune system Alzheimer s & Dementia

Key finding: Higher glial fibrillary acidic protein (GFAP) was associated with higher depressive symptoms. +4 more findings

• Biomarkers
• Brain Biology

Full summary, score breakdown and related studies → Original source