Newest studies

MicroRNA-223 Enhances Microglia-Dependent Clearance of Amyloid Beta Plaques and Ameliorates Behavioral Deficits in a Mouse Model of Alzheimer’s Disease

16/100 ⚠ Preprint — not yet peer-reviewed TREM2 and immune genetics bioRxiv

Key finding: Here, we report that intracerebroventricular (ICV) injection of miR-223 oligonucleotide mimic alleviated cognitive impairment, reduced amyloid beta (Aβ) pathology, and ameliorated the defects in synaptic marker expression in App NL-G-F AD model mice. +4 more findings

• Brain Biology
• Genetics

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Test-retest reliability of plasma biomarkers and digital cognitive metrics at clinically meaningful timescales

16/100 ⚠ Preprint — not yet peer-reviewed Biomarkers Research Square

Key finding: Test-retest reliability measures are essential for interpretation of meaningful effects over time for plasma and digital outcomes.

• Biomarkers
• Diagnosis
• Digital Tools

Scored 34 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Photobiomodulation of immune crosstalk rescues neuroinflammation in Alzheimer's disease models

48/100 ✓ Peer-reviewed Inflammation and the immune system Brain : a journal of neurology

Key finding: Here, we found that photobiomodulation (PBM) markedly reduced cerebral CD8+ T cells infiltration in the cortex of AD (APP/PS1 and 3×Tg) mice, thereby improving cognition, and alleviating AD-related pathology by mitigating neuronal damage and gliosis. +2 more findings

• Brain Biology

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Voluntary assisted dying views and experiences of Australians living with dementia: a qualitative study

32/100 ✓ Peer-reviewed End-of-life care Mortality

Key finding: The participants felt their living experiences of stigma and discrimination presented significant barriers to realising what they viewed as their right to VAD access. +1 more finding

• End-of-Life Care

Full summary, score breakdown and related studies → Original source

A phosphorylation‑independent monoclonal antibody improves detection of TDP‑43 pathology across frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and limbic predominant age related TDP‑43 encephalopathy neuropathological change

36/100 ✓ Peer-reviewed Treatments Journal of Neuropathology & Experimental Neurology

Key finding: In ADNC with stage 3 LATE-NC, MAb No. 9 revealed a greater limbic burden and labeled both α type and β type inclusions. +2 more findings

• Other Dementias
• Treatments
• Brain Biology

Full summary, score breakdown and related studies → Original source

Predictive Models for Cognitive Decline Assessment

48/100 ✓ Peer-reviewed Long-term cohort studies F1000Res

Key finding: This study contributes to the healthcare field by demonstrating the potential of providing a fast, transparent, and affordable assessment system that is accessible to low-income populations and clinics with limited budget. +1 more finding

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The Ocular Microbiome and Alzheimer’s Disease: Emerging Insights

16/100 ⚠ Preprint — not yet peer-reviewed Disease mechanisms Preprints.org

Key finding: We conclude by proposing a research framework that places the ocular microbiome as an emerging hypothesis warranting experimental validation, rather than an established contributor to AD.

• Brain Biology

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Alzheimer's Disease as the Result of Aberrant Reactivation of Embryonic Brain Pathways Silenced Decades Earlier

16/100 ⚠ Preprint — not yet peer-reviewed Drug development Research Square

Key finding: These findings shift AD modeling from passive proteotoxicity to an active, misregulated developmental structural engine, offering a mechanical framework that explains early olfactory vulnerability and non-linear anti-tau clinical trial responses. +2 more findings

• Brain Biology

Scored 24 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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FastEBM: Fast, Scalable, and Uncertainty-Aware Event-Based Disease Progression Modeling

16/100 ⚠ Preprint — not yet peer-reviewed Brain scans and imaging bioRxiv

Key finding: These results show that diffusion-based Markov geometry provides a scalable and robust alternative to conventional event-based modeling.

Scored 35 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Type 1 diabetes is associated with higher plasma levels of biomarkers of neurodegeneration and neuroinflammation

63/100 ✓ Peer-reviewed Biomarkers Frontiers in immunology

Key finding: 136 adults with T1D (n=90, age 52 years, 58% female, average HbA1c 7.7%) and without T1D (n=46, age 53 years, 57% female, average HbA1c 5.4%) were included. +4 more findings

• Biomarkers
• Brain Biology

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Associations of Alzheimer Disease and Related Dementia Neuropathologies With Timely Diagnosis of Dementia in Healthcare Settings

47/100 ✓ Peer-reviewed Brain tissue and pathology Neurology

Key finding: Of the 500 eligible participants (71% female, 95% non-Latino White, mean [SD] age at cohort dementia onset = 88 [7] years, mean [SD] years from onset to death = 4 [3]), only 54% received a timely diagnosis. +4 more findings

• Brain Biology
• Diagnosis

Full summary, score breakdown and related studies → Original source

Network Pharmacology and Molecular Docking Uncover Novel Candidate Compound-Target Actions of Yokukansan (Yi-Gan San) in the Behavioral and Psychological Symptoms of Dementia

16/100 ⚠ Preprint — not yet peer-reviewed Clinical safety Preprints.org

Key finding: In total, 45 constituents were mapped to 181 human target genes through measured compound-target edges. +4 more findings

Scored 27 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Eligibility for shingles vaccination and hospital-coded dementia in England and Wales: a regression discontinuity analysis in England

16/100 ⚠ Preprint — not yet peer-reviewed Getting a diagnosis medRxiv

Key finding: Eligibility was associated with a clear reduction in hospital-coded shingles diagnoses (RD estimate - 0.12 percentage points, 95% CI -0.153 to -0.079; p = 5.9 × 10 -10 ), but there was no evidence of a corresponding reduction in hospital-coded dementia diagnoses (RD estimate -0.06 percentage points, 95% CI -0.40 to 0.27; p = 0.72). +3 more findings

• Care Services
• Prevention

Scored 24 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Universal care under strain: navigating population ageing in Europe

30/100 ✓ Peer-reviewed Health systems and care delivery Drug discovery today

Key finding: Europe's ageing population is transforming universal healthcare from a financing challenge into a delivery-capacity challenge. +3 more findings

• Treatments

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Integrated Proteomic and Phosphoproteomic Profiling Reveals Distinct Disease- and Age-Related Molecular Alterations in the Retina and Hippocampus of APP/PS1/MAPT Mice

16/100 ⚠ Preprint — not yet peer-reviewed Getting a diagnosis Research Square

Key finding: The retina displayed earlier and broader AD-related molecular alterations than the hippocampus. +3 more findings

• Brain Biology

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Death in People with Down syndrome: Mortality statistics and novel predictors in US Medicaid and Medicare enrolled adults

16/100 ⚠ Preprint — not yet peer-reviewed Costs and economics medRxiv

Key finding: People with Down syndrome have higher age-specific mortality rates compared to the general population as well as peers with other intellectual and developmental disabilities. +1 more finding

• Policy
• Down Syndrome

Scored 48 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Caring in the Shadows: The Lived Experiences of family Caregivers of Older Adults with Dementia in Fragile and Conflict-Affected Setting in Ethiopia

16/100 ⚠ Preprint — not yet peer-reviewed Caregiving Research Square

Key finding: Caregiving for older adults with dementia in Northern Ethiopia is a totalizing and demanding experience that profoundly affects caregivers’ lives. +1 more finding

• Caregiving

Scored 27 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Effects of Practice Testing with Corrective Feedback on Long-Term BPSD Knowledge in Dementia Caregivers: Randomized Controlled Trial

16/100 ⚠ Preprint — not yet peer-reviewed Clinical trials Research Square

Key finding: Practice testing with detailed, corrective feedback is an effective intervention for targeting caregivers’ dementia-related knowledge.

• Clinical Trials
• Caregiving

Scored 29 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Immunoproteasome Deficiency Impairs Microglial Clearance and Worsens Tau and Amyloid Pathology

16/100 ⚠ Preprint — not yet peer-reviewed TREM2 and immune genetics bioRxiv

Key finding: Reanalysis of human single-nucleus transcriptomic datasets showed that reduced microglial immunoproteasome expression was associated with cargo-processing gene-program changes similar to those observed in immunoproteasome-deficient mouse microglia. +1 more finding

• Brain Biology
• Genetics

Scored 35 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Multidomain Lifestyle Intervention in Mild Cognitive Impairment: Subgroup Analysis of the SUPERBRAIN-MEET Randomized Trial

88/100 ✓ Peer-reviewed Prevention trials Neurology

Key finding: Of 300 randomized participants, 277 participants (mean age, 72.9 years; 69.3% female) were included in the modified intention-to-treat analysis (142 in the MLI group and 135 in the control group). +4 more findings

• Clinical Trials
• Early Stage
• Lifestyle

Full summary, score breakdown and related studies → Original source

Patient-Derived PSEN1 Cerebral Organoids Revealed Parallel Development of Amyloid-β Accumulation and Network Dysfunction

45/100 ✓ Peer-reviewed Biomarkers Cellular and molecular neurobiology

Key finding: Multielectrode array recordings from the differentiation day 60 (DD60) to at least DD130 revealed that AD organoids exhibited transient hyperexcitability and hypersynchrony compared with wild-type (WT) controls, followed by a gradual decline in activity. +2 more findings

• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

Neighborhood Disadvantage and Dementia Risk Among Older Patients With Kidney Failure: Differences by Race/Ethnicity and Urbanicity

45/100 ✓ Peer-reviewed Risk factors Kidney Medicine

Key finding: Older patients with kidney failure residing in high-disadvantage neighborhoods, particularly Black patients and those in suburban, rural, or small-town areas, had a higher risk of ADRD compared with those in low-disadvantage neighborhoods. +4 more findings

• Health Equity
• Risk Factors
• Diagnosis

Full summary, score breakdown and related studies → Original source

Association Between Plasma Phosphorylated Tau-217 and Cognition in Parkinson's Disease

45/100 ✓ Peer-reviewed Biomarkers Movement disorders : official journal of the Movement Disorder Society

Key finding: No significant differences in p-tau217, GFAP and NfL level were observed between groups (pFDR > 0.08). +4 more findings

• Biomarkers
• Other Dementias

Full summary, score breakdown and related studies → Original source

Epigenetic Clock Trajectories and Brain Health in Midlife

16/100 ⚠ Preprint — not yet peer-reviewed Biomarkers medRxiv

Key finding: Middle-aged adults with faster 15-year epigenetic aging trajectories demonstrated worse cognitive performance, whereas those with slower biological aging trajectories exhibited cognitive resilience and more favorable AD biomarker profiles. +4 more findings

• Biomarkers

Scored 31 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Delirium Superimposed on Dementia

30/100 ✓ Peer-reviewed Clinical safety Swiss Archives of Neurology Psychiatry and Psychotherapy

Key finding: Dementia is a known risk factor for delirium. +4 more findings

Full summary, score breakdown and related studies → Original source