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49/100

✓ Peer-reviewed alzhub usefulness score 49 out of 100. Prevention trials

Topic: Risk, prevention and care in population studies

At baseline, 219 participants (18%) had CF. The risk for developing CF at 2 years was higher in the control group (risk ratio [RR], 1.88, p = .003). The intervention effect was not modified by baseline CF (p = .493). Reversal from CF to no-CF group was more likely in the intervention group, and progression to or persisting with CF was more likely in the control group. Compared with healthy participants (n = 401) at baseline, the MCI group (n = 244) had an RR of 5.10, pre-frail/frail (n = 336) of 3.06, and CF of 30.61 for having CF at 2 years, with no difference between MCI and pre-frail/frail groups (p = .116). The 2-year multidomain lifestyle intervention was effective in preventing and reversing CF. Participants with MCI or pre-frailty/frailty were both at increased risk for CF compared with healthy participants.

Key findings

At baseline, 219 participants (18%) had CF.
The risk for developing CF at 2 years was higher in the control group (risk ratio [RR], 1.88, p = .003).
The intervention effect was not modified by baseline CF (p = .493).
Reversal from CF to no-CF group was more likely in the intervention group, and progression to or persisting with CF was more likely in the control group.
Compared with healthy participants (n = 401) at baseline, the MCI group (n = 244) had an RR of 5.10, pre-frail/frail (n = 336) of 3.06, and CF of 30.61 for having CF at 2 years, with no difference between MCI and pre-frail/frail groups (p = .116).

Why it matters

In this post hoc analysis of the FINGER trial, a 2-year multidomain lifestyle intervention reduced the risk of developing cognitive frailty and increased the chance of reversing it compared with the control group. Participants with mild cognitive impairment or frailty were at higher risk of cognitive frailty than healthy participants.

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Study details

Participants401
Evidence strengthHigh

How this study scored 49/100

Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (The Journals of Gerontology Series A)
Journal's citation record	3 / 4	The Journals of Gerontology Series A: journal h-index 274 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	5 / 5	Rated “high” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	2 / 4	401 participants
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	1 / 7	Cited 2 times (OpenAlex, 2026-10-10)
Citations per year	0 / 5	0.7 citations a year over 3 year(s) since 2025
Impact for its field and year	2 / 6	Cited 1.1× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	0 / 4	Cited 2 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	3 / 4	Last-listed author Tiia Ngandu: h-index 54 (OpenAlex, whole career)
Institution's track record	2 / 3	Imperial College London: institution h-index 1,744 (OpenAlex)
Multi-centre collaboration	3 / 3	OpenAlex lists 12 institution(s) in 4 countries
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 41397903)
Free to read	2 / 2	Free to read
Total	49 / 100	—

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Read the original

Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.

APA 7th

Pöyhönen, J., Roitto, H., Lehtisalo, J., Levälahti, E., Strandberg, T. E., Kivipelto, M., et al. (2025). Impact of multidomain lifestyle intervention on dynamics of cognitive frailty: post hoc analysis of the FINGER trial. The Journals of Gerontology Series A. https://doi.org/10.1093/gerona/glaf275

Vancouver

Pöyhönen J, Roitto H, Lehtisalo J, Levälahti E, Strandberg TE, Kivipelto M, et al. Impact of multidomain lifestyle intervention on dynamics of cognitive frailty: post hoc analysis of the FINGER trial. The Journals of Gerontology Series A. 2025. doi:10.1093/gerona/glaf275. PMID: 41397903.

BibTeX

@article{poyhonen2025-41397903,
  author  = {Pöyhönen, Johanna and Roitto, Hanna‐Maria and Lehtisalo, Jenni and Levälahti, Esko and Strandberg, Timo E. and Kivipelto, Miia and Kulmala, Jenni and Antikaínen, Riitta and others},
  title   = {{Impact of multidomain lifestyle intervention on dynamics of cognitive frailty: post hoc analysis of the FINGER trial}},
  journal = {The Journals of Gerontology Series A},
  year    = {2025},
  doi     = {10.1093/gerona/glaf275},
  pmid    = {41397903},
  url     = {https://doi.org/10.1093/gerona/glaf275}
}

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