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Clinical recognition of frontotemporal dementia with right temporal predominance: a consensus statement from the International Working Group
Hülya Ulugut, Kyan Younes, Maxime Montembeault, Maxime Bertoux, Muireann Irish, Fiona Kumfor, Giorgio Fumagalli, Bedia Samancı et al.. Communications Medicine, 2025-12-12
Topic: Risk, prevention and care in population studies
Accurate diagnosis of frontotemporal dementia (FTD) with right anterior temporal lobe (RATL) predominance remains challenging due to lack of clinical characterization, and standardized terminology. The recent research of the International Working Group (IWG) identified common symptoms but also unveiled broad terminologies lacking precision and operationalization, with risk of misdiagnoses, inappropriate referrals and poor clinical management. Based on the published evidence (91267 articles screened) and expert opinion (105 FTD specialists across 52 centers) by using the nominal group technique, the IWG delineates three primary domains of impairment causing behavioral, memory and language problems: (i) multimodal knowledge of non-verbal information including people, living beings, landmarks, flavors/odors, sounds, bodily sensations, emotions and social cues; (ii) socioemotional behavior encompassing emotion expression, social response and motivation; and (iii) prioritization for focus on specific interests, hedonic valuation and personal preferences. This study establishes a consensus on clinical profile, phenotypic nomenclature, and future directions to enhance diagnostic precision and therapeutic interventions.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Ulugut, H., Younes, K., Montembeault, M., Bertoux, M., Irish, M., Kumfor, F., et al. (2025). Clinical recognition of frontotemporal dementia with right temporal predominance: a consensus statement from the International Working Group. Communications Medicine. https://doi.org/10.1038/s43856-025-01252-4
Vancouver
Ulugut H, Younes K, Montembeault M, Bertoux M, Irish M, Kumfor F, et al. Clinical recognition of frontotemporal dementia with right temporal predominance: a consensus statement from the International Working Group. Communications Medicine. 2025. doi:10.1038/s43856-025-01252-4. PMID: 41387629.
BibTeX
@article{ulugut2025-41387629,
author = {Ulugut, Hülya and Younes, Kyan and Montembeault, Maxime and Bertoux, Maxime and Irish, Muireann and Kumfor, Fiona and Fumagalli, Giorgio and Samancı, Bedia and others},
title = {{Clinical recognition of frontotemporal dementia with right temporal predominance: a consensus statement from the International Working Group}},
journal = {Communications Medicine},
year = {2025},
doi = {10.1038/s43856-025-01252-4},
pmid = {41387629},
url = {https://doi.org/10.1038/s43856-025-01252-4}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
Key findings
- Accurate diagnosis of frontotemporal dementia (FTD) with right anterior temporal lobe (RATL) predominance remains challenging due to lack of clinical characterization, and standardized terminology.
- The recent research of the International Working Group (IWG) identified common symptoms but also unveiled broad terminologies lacking precision and operationalization, with risk of misdiagnoses, inappropriate referrals and poor clinical management.
- Based on the published evidence (91267 articles screened) and expert opinion (105 FTD specialists across 52 centers) by using the nominal group technique, the IWG delineates three primary domains of impairment causing behavioral, memory and language problems: (i) multimodal knowledge of non-verbal information including people, living beings, landmarks, flavors/odors, sounds, bodily sensations, emotions and social cues; (ii) socioemotional behavior encompassing emotion expression, social response and motivation; and (iii) prioritization for focus on specific interests, hedonic valuation and personal preferences.
- This study establishes a consensus on clinical profile, phenotypic nomenclature, and future directions to enhance diagnostic precision and therapeutic interventions.
Why it matters
This consensus statement from the International Working Group characterizes clinical profiles and nomenclature for frontotemporal dementia with right temporal predominance to enhance diagnostic precision. It aims to improve diagnosis and future therapeutic interventions but does not offer a treatment or cure.
Study details
- Evidence strengthLow
How this study scored 40/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Communications Medicine) |
| Journal's citation record | 0 / 4 | Communications Medicine: journal h-index 55 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 2 / 7 | Cited 8 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 2.7 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 3 / 6 | Cited 5.1× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 1 / 4 | Cited 8 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 1 / 4 | Last-listed author Matthew A Rouse: h-index 15 (OpenAlex, whole career) |
| Institution's track record | 3 / 3 | Stanford University: institution h-index 2,684 (OpenAlex) |
| Multi-centre collaboration | 3 / 3 | OpenAlex lists 62 institution(s) in 17 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 41387629) |
| Free to read | 2 / 2 | Free to read |
| Total | 40 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1038/s43856-025-01252-4
- PubMed: 41387629
- Original source →
- Free full text: Communications Medicine →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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Referenced by this study and also in the alzhub library, so you can read them here.
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