Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 21,001–21,025 of 27,380 studies, newest first · page 841 of 1096.
February 2010 12
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2010-02-01
Late-life depression, mild cognitive impairment, and dementia: possible continuum?
51/100 ✓ Peer-reviewed How common it is The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
Key finding: Prevalence and incidence of depressive symptoms or syndromes in MCI vary as a result of different diagnostic criteria and different sampling and assessment procedures. +2 more findings
Full summary, score breakdown and related studies → Original source
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2010-02-01
Primary progressive aphasia: clinicopathological correlations
47/100 ✓ Peer-reviewed Getting a diagnosis Nature reviews. Neurology
Key finding: These data suggest an association between a specific PPA variant and an underlying pathology, although many cases of PPA are associated with an unexpected pathology. +1 more finding
Full summary, score breakdown and related studies → Original source
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2010-02-01
Brief cognitive screening instruments: an update
49/100 ✓ Peer-reviewed Getting a diagnosis International journal of geriatric psychiatry
Key finding: Dementia remains under-diagnosed in the elderly population. +1 more finding
Full summary, score breakdown and related studies → Original source
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2010-02-01
The use of PET in Alzheimer disease
49/100 ✓ Peer-reviewed Getting a diagnosis Nature reviews. Neurology
Key finding: In patients with AD, PET can be used to investigate changes in cerebral glucose metabolism, various neurotransmitter systems, neuroinflammation, and the protein aggregates that are characteristic of the disease, notably the amyloid deposits. +4 more findings
Full summary, score breakdown and related studies → Original source
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2010-02-01
Association between acute care and critical illness hospitalization and cognitive function in older adults
71/100 ✓ Peer-reviewed Getting a diagnosis JAMA
Key finding: During a mean (SD) follow-up of 6.1 (3.2) years, 1601 participants had no hospitalization, 1287 had 1 or more noncritical illness hospitalizations, and 41 had 1 or more critical illness hospitalizations. +3 more findings
Full summary, score breakdown and related studies → Original source
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2010-02-01
The clinical use of structural MRI in Alzheimer disease
56/100 ✓ Peer-reviewed Getting a diagnosis Nature reviews. Neurology
Key finding: Atrophy of medial temporal structures is now considered to be a valid diagnostic marker at the mild cognitive impairment stage. +4 more findings
Full summary, score breakdown and related studies → Original source
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2010-02-01
Comparison of topiramate and risperidone for the treatment of behavioral disturbances of patients with Alzheimer disease: a double-blind, randomized clinical trial
54/100 ✓ Peer-reviewed Treatments Journal of clinical psychopharmacology
Key finding: Forty-eight patients were randomized to treatment with either topiramate or risperidone, and 41 patients (21 of 25 in topiramate group and 20 of 23 in risperidone group) completed the trial. +3 more findings
Full summary, score breakdown and related studies → Original source
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2010-02-01
Improving depression and enhancing resilience in family dementia caregivers: a pilot randomized placebo-controlled trial of escitalopram
58/100 ✓ Peer-reviewed Treatments The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
Key finding: Among caregivers, this small randomized controlled trial found that escitalopram use resulted in improvement in depression, resilience, burden and distress, and quality of life. +3 more findings
Full summary, score breakdown and related studies → Original source
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2010-02-01
A randomized, placebo-controlled trial of latrepirdine in Huntington disease
61/100 ✓ Peer-reviewed Treatments Archives of neurology
Key finding: Short-term administration of latrepirdine is well tolerated in patients with HD and may have a beneficial effect on cognition. +2 more findings
Full summary, score breakdown and related studies → Original source
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2010-02-01
Healthy brain aging: role of exercise and physical activity
57/100 ✓ Peer-reviewed Treatments Clinics in geriatric medicine
Key finding: There is increasing evidence to suggest that physical activity has a protective effect on brain functioning in older people. +1 more finding
Full summary, score breakdown and related studies → Original source
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2010-02-01
Sertraline for the treatment of depression in Alzheimer disease
71/100 ✓ Peer-reviewed Treatments The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
Key finding: Sertraline did not demonstrate efficacy for the treatment depression symptoms in patients with AD. +1 more finding
Full summary, score breakdown and related studies → Original source
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2010-02-01
Correlation of longitudinal cerebrospinal fluid biomarkers with cognitive decline in healthy older adults
54/100 ✓ Peer-reviewed Genetics Archives of neurology
Key finding: Changes in CSF biomarker levels may identify early neurodegenerative processes of Alzheimer disease. +1 more finding
Full summary, score breakdown and related studies → Original source
January 2010 13
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2010-01-29
Glucagon-like peptide 1 receptor stimulation as a means of neuroprotection
36/100 ✓ Peer-reviewed Drug development British journal of pharmacology
Key finding: Similar data suggest that the same effects may occur in other peripheral tissues.
Full summary, score breakdown and related studies → Original source
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2010-01-27
Alzheimer's Disease
59/100 ✓ Peer-reviewed Disease mechanisms New England Journal of Medicine
This review of Alzheimer's disease assembles a variety of findings relevant to the mechanism of the disease and ties them together using the current understanding of the basis of the loss of cognition: the accumulation of misfolded proteins, which cause oxidative and inflammatory damage to the brain and, ultimately, synaptic dysfunction.
Full summary, score breakdown and related studies → Original source
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2010-01-27
Serum levels of S100B and NSE proteins in Alzheimer's disease patients
43/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of neuroinflammation
Key finding: Alzheimer's disease is the most common dementia in the elderly, and the potential of peripheral biochemical markers as complementary tools in the neuropsychiatric evaluation of these patients has claimed further attention. +3 more findings
Full summary, score breakdown and related studies → Original source
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2010-01-26
A Drosophila model for TDP-43 proteinopathy
49/100 ✓ Peer-reviewed Brain tissue and pathology Proceedings of the National Academy of Sciences of the United States of America
Key finding: To test whether increased expression of wide-type human TDP-43 (hTDP-43) may cause neurotoxicity in vivo, we generated transgenic flies expressing hTDP-43 in various neuronal subpopulations. +3 more findings
Full summary, score breakdown and related studies → Original source
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2010-01-25
Management of behavioral problems in Alzheimer's disease
36/100 ✓ Peer-reviewed Treatments International psychogeriatrics
Key finding: In addition to cognitive and functional decline, diverse behavioral changes manifest with increasing severity over time, presenting significant management challenges for caregivers and health care professionals. +1 more finding
Full summary, score breakdown and related studies → Original source
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2010-01-25
Whole genome association study of brain-wide imaging phenotypes for identifying quantitative trait loci in MCI and AD: A study of the ADNI cohort
45/100 ✓ Peer-reviewed Genetics NeuroImage
Key finding: Hierarchical clustering and heat maps were used to analyze the GWAS results and associations are reported at two significance thresholds (p<10(-7) and p<10(-6)). +3 more findings
Full summary, score breakdown and related studies → Original source
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2010-01-25
When does brain aging accelerate? Dangers of quadratic fits in cross-sectional studies
45/100 ✓ Peer-reviewed Hippocampus size on brain scans NeuroImage
Key finding: We conclude that caution should be exerted in inferring age-trajectories from global fit models, e.g. the quadratic model. +1 more finding
Full summary, score breakdown and related studies → Original source
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2010-01-25
Communication breaks-Down: from neurodevelopment defects to cognitive disabilities in Down syndrome
40/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Progress in neurobiology
Key finding: Cognitive disabilities in DS appear to result mainly from two pathological processes: neurogenesis impairment and Alzheimer-like degeneration.
Full summary, score breakdown and related studies → Original source
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2010-01-21
Factors associated with prolonged delirium: a systematic review
57/100 ✓ Peer-reviewed End-of-life care International psychogeriatrics
Key finding: Preliminary findings suggest that some factors may identify those at risk for persistent delirium; however, more research is needed. +4 more findings
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2010-01-20
Placebo interventions for all clinical conditions
71/100 ✓ Peer-reviewed Risk factors The Cochrane database of systematic reviews
Key finding: Main results Outcome data were available in 202 out of 234 included trials, investigating 60 clinical conditions.
Full summary, score breakdown and related studies → Original source
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2010-01-19
Nursing home funding -- deal or no deal ? -- an Irish perspective
38/100 ✓ Peer-reviewed Health systems and care delivery Age and Ageing
Key finding: The costs of illness can be huge; medical bankruptcy is a significant problem in the United States [9].
Full summary, score breakdown and related studies → Original source
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2010-01-18
The dysregulation of intracellular calcium in Alzheimer disease
36/100 ✓ Peer-reviewed Disease mechanisms Cell calcium
Key finding: Mutations causing FAD also result in the dysregulation of neuronal calcium (Ca2+) handling and may contribute to AD pathogenesis, an idea termed the 'calcium hypothesis' of AD. +2 more findings
Full summary, score breakdown and related studies → Original source
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2010-01-18
Automated 3D mapping of baseline and 12-month associations between three verbal memory measures and hippocampal atrophy in 490 ADNI subjects
45/100 ✓ Peer-reviewed Digital health tools NeuroImage
Key finding: We observed no significant correlations between delayed recall performance and hippocampal radial distance on any of the three verbal memory measures in NC. +2 more findings
Full summary, score breakdown and related studies → Original source
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